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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PKNOX1_TGIF2
Z-value: 0.76
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Transcription factors associated with PKNOX1_TGIF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TGIF2 | hg38_v1_chr20_+_36574535_36574672 | 0.46 | 6.6e-13 | Click! |
| PKNOX1 | hg38_v1_chr21_+_42974510_42974649 | -0.21 | 2.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PKNOX1_TGIF2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 45.9 | GO:0042493 | response to drug(GO:0042493) |
| 2.8 | 30.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 2.3 | 18.0 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
| 6.0 | 17.9 | GO:1904772 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 2.0 | 14.1 | GO:0008295 | spermine metabolic process(GO:0008215) spermidine biosynthetic process(GO:0008295) |
| 0.1 | 13.8 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 3.2 | 12.9 | GO:0071733 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.4 | 12.7 | GO:0034080 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 1.4 | 12.3 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.5 | 12.2 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 82.4 | GO:0005654 | nucleoplasm(GO:0005654) |
| 1.9 | 30.6 | GO:0005642 | annulate lamellae(GO:0005642) |
| 1.1 | 17.9 | GO:0045120 | pronucleus(GO:0045120) |
| 0.2 | 17.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 16.1 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.2 | 15.5 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 1.3 | 12.9 | GO:0097255 | R2TP complex(GO:0097255) |
| 2.1 | 12.3 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 3.9 | 11.8 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.7 | 11.6 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 58.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 2.0 | 30.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 1.8 | 17.9 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 0.2 | 14.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.5 | 13.2 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 2.6 | 12.9 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.0 | 12.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.1 | 12.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.9 | 12.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 12.5 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 62.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.6 | 37.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.3 | 21.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 20.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.3 | 13.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 12.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 11.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 9.8 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.1 | 6.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 6.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 58.4 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 1.3 | 36.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.6 | 15.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.7 | 14.1 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.3 | 12.9 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.8 | 12.7 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.3 | 12.5 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 11.6 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.3 | 11.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.3 | 11.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |