Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for PLAG1
Z-value: 0.85
Motif logo
Transcription factors associated with PLAG1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAG1 | hg38_v1_chr8_-_56211257_56211309 | 0.25 | 1.8e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAG1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 27.8 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.9 | 27.2 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.3 | 22.8 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.9 | 21.7 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 6.7 | 20.0 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.6 | 19.5 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.9 | 18.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 5.7 | 17.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 2.0 | 13.7 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.4 | 12.0 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 71.1 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 0.1 | 31.1 | GO:0098793 | presynapse(GO:0098793) |
| 0.7 | 27.8 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.4 | 24.8 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 19.5 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.2 | 19.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 3.4 | 17.1 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.5 | 13.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) platelet dense tubular network membrane(GO:0031095) |
| 0.2 | 10.6 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 2.4 | 9.7 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 27.8 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 1.0 | 27.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.4 | 23.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.6 | 21.7 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 5.1 | 20.5 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.6 | 20.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.8 | 19.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 3.4 | 17.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 16.3 | GO:0004620 | phospholipase activity(GO:0004620) |
| 0.3 | 11.3 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.7 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.6 | 17.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.3 | 17.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 11.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 8.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 8.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 7.0 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 6.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.4 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 4.7 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 27.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.4 | 27.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.8 | 17.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 10.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 10.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 10.2 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.2 | 9.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 8.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.5 | 7.5 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 6.1 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |