ISMARA results: PLAGL1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PLAGL1

Z-value: 2.46

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Transcription factors associated with PLAGL1

Gene Symbol	Gene ID	Gene Info
PLAGL1 Ensembl NCBI GeneCards UniProt	ENSG00000118495.20	PLAGL1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PLAGL1	hg38_v1_chr6_-_144008118_144008268	-0.02	7.3e-01	Click!

Activity profile of PLAGL1 motif

Sorted Z-values of PLAGL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PLAGL1

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Promoter	Score	Transcript	Gene	Gene Info
chr9_+_136979042 Show fit	61.96	ENST00000446677.2	PTGDS Ensembl NCBI GeneCards UniProt Show fit	prostaglandin D2 synthase
chr6_-_73452124 Show fit	59.60	ENST00000680833.1	CGAS Ensembl NCBI GeneCards UniProt Show fit	cyclic GMP-AMP synthase
chr16_+_176659 Show fit	59.39	ENST00000320868.9 ENST00000397797.1	HBA1 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit alpha 1
chr16_+_172869 Show fit	48.30	ENST00000251595.11 ENST00000397806.1 ENST00000484216.1	HBA2 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit alpha 2
chr16_-_23557331 Show fit	46.24	ENST00000563232.1 ENST00000449606.7	EARS2 Ensembl NCBI GeneCards UniProt Show fit	glutamyl-tRNA synthetase 2, mitochondrial
chr12_-_124567464 Show fit	43.48	ENST00000458234.5	NCOR2 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor corepressor 2
chr22_-_19524400 Show fit	35.84	ENST00000618236.2	CLDN5 Ensembl NCBI GeneCards UniProt Show fit	claudin 5
chr12_-_54588636 Show fit	35.69	ENST00000257905.13	PPP1R1A Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1 regulatory inhibitor subunit 1A
chr10_+_46579084 Show fit	35.65	ENST00000512997.5 ENST00000374321.9 ENST00000503753.5	SYT15 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 15
chr12_-_54588516 Show fit	34.15	ENST00000547431.5	PPP1R1A Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1 regulatory inhibitor subunit 1A

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	190.0	GO:0006910	phagocytosis, recognition(GO:0006910)
4.7	165.4	GO:0045187	regulation of circadian sleep/wake cycle, sleep(GO:0045187)
2.7	128.2	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
2.9	119.9	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
6.2	118.3	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2	92.6	GO:0043547	positive regulation of GTPase activity(GO:0043547)
3.0	89.6	GO:0045494	photoreceptor cell maintenance(GO:0045494)
1.8	89.5	GO:0015701	bicarbonate transport(GO:0015701)
4.5	86.2	GO:0015671	gas transport(GO:0015669) oxygen transport(GO:0015671)
3.1	86.0	GO:0032011	ARF protein signal transduction(GO:0032011)

Showing 1 to 10 of 1,160 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	573.7	GO:0031224	intrinsic component of membrane(GO:0031224)
5.7	193.2	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
3.6	180.3	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.9	128.7	GO:0072562	blood microparticle(GO:0072562)
1.0	114.7	GO:0034705	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
1.6	113.7	GO:0005581	collagen trimer(GO:0005581)
4.5	112.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
1.5	111.7	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4	98.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.9	97.0	GO:0005796	Golgi lumen(GO:0005796)

Showing 1 to 10 of 341 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	786.0	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.3	343.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.5	211.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.6	133.4	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
1.2	128.8	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.6	105.4	GO:0004890	GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.3	98.5	GO:0004888	transmembrane signaling receptor activity(GO:0004888)
23.8	95.4	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
1.5	94.4	GO:0070412	R-SMAD binding(GO:0070412)
6.1	91.4	GO:0005344	oxygen transporter activity(GO:0005344)

Showing 1 to 10 of 680 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	310.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	136.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.1	134.1	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
2.0	97.5	NABA COLLAGENS	Genes encoding collagen proteins
2.3	95.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.1	88.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.5	85.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	78.4	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
1.2	76.9	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
1.3	75.5	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2

Showing 1 to 10 of 113 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	438.3	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
1.2	207.1	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
1.3	169.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
2.4	137.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
1.1	135.3	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
2.8	119.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
1.6	117.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
2.1	114.7	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
7.0	111.8	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
2.5	93.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation

Showing 1 to 10 of 158 entries

Results for PLAGL1

Z-value: 2.46

Motif logo

Transcription factors associated with PLAGL1

Activity-expression correlation:

Activity profile of PLAGL1 motif

Sorted Z-values of PLAGL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PLAGL1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: