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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU1F1
Z-value: 0.62
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Transcription factors associated with POU1F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU1F1 | hg38_v1_chr3_-_87276462_87276494 | 0.22 | 1.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU1F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 3.5 | 17.4 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 0.5 | 12.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.7 | 12.0 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.4 | 11.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.6 | 8.9 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 8.4 | GO:0007498 | mesoderm development(GO:0007498) |
| 1.8 | 7.0 | GO:1904749 | regulation of protein localization to nucleolus(GO:1904749) |
| 0.1 | 6.6 | GO:0007032 | endosome organization(GO:0007032) |
| 0.4 | 6.1 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.5 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 1.7 | 12.1 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.5 | 12.0 | GO:0005685 | U1 snRNP(GO:0005685) |
| 1.6 | 11.0 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 7.6 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 7.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 6.9 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 6.9 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.6 | 5.9 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 5.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 14.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 2.4 | 12.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 2.4 | 12.0 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.1 | 7.4 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 1.1 | 6.6 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.2 | 6.1 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.2 | 6.0 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 1.2 | 5.9 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.1 | 5.5 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.6 | 11.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 10.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 5.3 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 5.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 4.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 4.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 4.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 3.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 11.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 7.7 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 7.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 5.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 5.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 4.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 4.3 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 4.2 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.3 | 4.0 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |