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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU2F1
Z-value: 0.80
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Transcription factors associated with POU2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F1 | hg38_v1_chr1_+_167220870_167220927 | 0.16 | 1.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90021567 Show fit | 20.58 |
ENST00000436451.2
|
immunoglobulin kappa variable 6D-21 (non-functional) |
|
| chr2_-_88992903 Show fit | 19.69 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr2_+_90069662 Show fit | 18.67 |
ENST00000390271.2
|
immunoglobulin kappa variable 6D-41 (non-functional) |
|
| chr13_-_46142834 Show fit | 16.10 |
ENST00000674665.1
|
lymphocyte cytosolic protein 1 |
|
| chr11_-_58575846 Show fit | 15.42 |
ENST00000395074.7
|
leupaxin |
|
| chr14_-_106185387 Show fit | 15.07 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
|
| chr3_-_155806260 Show fit | 15.04 |
ENST00000534941.2
ENST00000340171.7 |
chromosome 3 open reading frame 33 |
|
| chr1_+_158831323 Show fit | 14.36 |
ENST00000368141.5
|
myeloid cell nuclear differentiation antigen |
|
| chr14_-_106025628 Show fit | 13.97 |
ENST00000631943.1
|
immunoglobulin heavy variable 7-4-1 |
|
| chr3_-_121660892 Show fit | 12.92 |
ENST00000428394.6
ENST00000314583.8 |
hematopoietic cell-specific Lyn substrate 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 61.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.5 | 47.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 44.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 43.2 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.8 | 16.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 1.9 | 15.4 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.6 | 14.4 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
| 4.4 | 13.2 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.9 | 12.9 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 10.9 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 57.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.6 | 34.4 | GO:0002102 | podosome(GO:0002102) |
| 0.2 | 22.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 16.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 15.1 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 11.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 10.5 | GO:0045121 | membrane raft(GO:0045121) |
| 0.1 | 10.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 8.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 1.0 | 6.8 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 120.9 | GO:0003823 | antigen binding(GO:0003823) |
| 1.0 | 57.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.3 | 15.1 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 14.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 1.2 | 13.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 11.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 6.8 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 6.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.2 | 6.0 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.1 | 5.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.5 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.2 | 14.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.7 | 11.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 9.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 6.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 5.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 3.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 3.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.6 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.0 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.4 | 11.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 9.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 9.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 9.3 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 7.7 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 6.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 6.3 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.2 | 6.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 4.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |