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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU2F2_POU3F1
Z-value: 2.64
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg38_v1_chr19_-_42132391_42132455 | 0.48 | 4.7e-14 | Click! |
| POU3F1 | hg38_v1_chr1_-_38046785_38046802 | 0.27 | 6.0e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106117159 Show fit | 113.84 |
ENST00000390601.3
|
immunoglobulin heavy variable 3-11 |
|
| chr14_-_106470788 Show fit | 105.15 |
ENST00000434710.1
|
immunoglobulin heavy variable 3-43 |
|
| chr14_-_106538331 Show fit | 97.59 |
ENST00000390624.3
|
immunoglobulin heavy variable 3-48 |
|
| chr2_+_90209873 Show fit | 93.23 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr16_+_33802683 Show fit | 92.90 |
ENST00000570121.2
|
immunoglobulin heavy variable 3/OR16-12 (non-functional) |
|
| chr2_-_89040745 Show fit | 92.79 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr2_-_88992903 Show fit | 85.33 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr2_+_90100235 Show fit | 79.14 |
ENST00000492446.1
|
immunoglobulin kappa variable 1D-16 |
|
| chr16_+_32066065 Show fit | 75.00 |
ENST00000354689.6
|
immunoglobulin heavy variable 3/OR16-9 (non-functional) |
|
| chr2_+_90082635 Show fit | 73.73 |
ENST00000483379.1
|
immunoglobulin kappa variable 1D-17 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 2277.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 4.2 | 739.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 77.4 | GO:0002250 | adaptive immune response(GO:0002250) |
| 11.7 | 58.3 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.5 | 51.7 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 5.2 | 41.3 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.2 | 35.4 | GO:0051591 | response to cAMP(GO:0051591) |
| 10.8 | 32.5 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 2.5 | 29.7 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
| 4.0 | 27.8 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.7 | 1045.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.6 | 949.0 | GO:0005615 | extracellular space(GO:0005615) |
| 2.2 | 395.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 374.3 | GO:0005576 | extracellular region(GO:0005576) |
| 8.1 | 32.5 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 6.1 | 30.3 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.1 | 29.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 25.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 25.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.2 | 24.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 1903.6 | GO:0003823 | antigen binding(GO:0003823) |
| 17.4 | 1045.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.6 | 51.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 4.6 | 41.3 | GO:0043426 | MRF binding(GO:0043426) |
| 2.0 | 32.7 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 4.6 | 32.5 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.5 | 32.1 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.9 | 29.7 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 5.9 | 29.4 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 7.0 | 28.0 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 62.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.3 | 46.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.5 | 32.0 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 1.2 | 28.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 24.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 12.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 11.0 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.2 | 8.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 7.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 6.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 30.3 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.4 | 29.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.1 | 28.0 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 27.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.8 | 19.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.6 | 17.2 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.7 | 15.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.9 | 10.7 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.5 | 10.2 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.3 | 8.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |