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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU3F3_POU3F4
Z-value: 0.94
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Transcription factors associated with POU3F3_POU3F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F4 | hg38_v1_chrX_+_83508284_83508309 | 0.11 | 1.1e-01 | Click! |
| POU3F3 | hg38_v1_chr2_+_104854104_104854124 | 0.07 | 3.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F3_POU3F4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_45378519 Show fit | 19.22 |
ENST00000558163.1
ENST00000396659.8 ENST00000675323.1 ENST00000558336.5 |
glycine amidinotransferase |
|
| chr14_-_20802402 Show fit | 14.79 |
ENST00000412779.2
|
ribonuclease A family member 1, pancreatic |
|
| chr5_+_141382702 Show fit | 14.34 |
ENST00000617050.1
ENST00000518325.2 |
protocadherin gamma subfamily A, 7 |
|
| chr14_-_20802836 Show fit | 13.89 |
ENST00000397967.5
ENST00000555698.5 ENST00000397970.4 ENST00000340900.3 |
ribonuclease A family member 1, pancreatic |
|
| chr3_-_58627596 Show fit | 13.66 |
ENST00000474531.5
ENST00000465970.1 |
family with sequence similarity 107 member A |
|
| chr1_+_103655760 Show fit | 12.75 |
ENST00000370083.9
|
amylase alpha 1A |
|
| chr5_+_126423176 Show fit | 10.25 |
ENST00000542322.5
ENST00000544396.5 |
GRAM domain containing 2B |
|
| chr1_-_103696209 Show fit | 10.16 |
ENST00000330330.10
|
amylase alpha 1B |
|
| chr1_+_103750406 Show fit | 10.01 |
ENST00000370079.3
|
amylase alpha 1C |
|
| chr1_+_103749898 Show fit | 9.93 |
ENST00000622339.5
|
amylase alpha 1C |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.3 | 28.1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 1.3 | 19.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 14.9 | GO:0007586 | digestion(GO:0007586) |
| 0.1 | 13.8 | GO:0070268 | cornification(GO:0070268) |
| 1.0 | 13.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.6 | 9.4 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.3 | 9.3 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 1.2 | 9.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.6 | 7.7 | GO:0044334 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 29.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 15.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 13.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 1.0 | 13.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.6 | 11.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.7 | 9.4 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.6 | 7.7 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 7.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 6.4 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.1 | 6.1 | GO:0005901 | caveola(GO:0005901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 28.7 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 9.1 | 27.2 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.6 | 19.2 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 1.5 | 17.4 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 13.9 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.2 | 13.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.7 | 9.4 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.3 | 7.7 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.8 | 7.5 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 7.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 13.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.6 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 5.8 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 5.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 5.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 3.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 3.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 57.3 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.1 | 18.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 13.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 13.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 7.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 6.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 6.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 5.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 4.9 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 4.8 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |