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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU4F1_POU4F3
Z-value: 1.09
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Transcription factors associated with POU4F1_POU4F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU4F1 | hg38_v1_chr13_-_78603539_78603595 | 0.36 | 4.6e-08 | Click! |
| POU4F3 | hg38_v1_chr5_+_146338835_146338846 | 0.23 | 5.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU4F1_POU4F3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 58.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.5 | 38.9 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 7.2 | 36.0 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.1 | 27.9 | GO:0048511 | rhythmic process(GO:0048511) |
| 3.7 | 26.0 | GO:2000768 | positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 0.3 | 25.0 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 2.1 | 23.4 | GO:1900165 | negative regulation of interleukin-6 secretion(GO:1900165) |
| 3.3 | 23.3 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.6 | 19.4 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.1 | 17.2 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 58.2 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 43.0 | GO:0009986 | cell surface(GO:0009986) |
| 9.0 | 36.0 | GO:0035363 | histone locus body(GO:0035363) |
| 0.0 | 28.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.4 | 26.0 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 17.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 12.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.3 | 11.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 10.2 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 1.4 | 10.1 | GO:0036157 | outer dynein arm(GO:0036157) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 58.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 45.8 | GO:0003677 | DNA binding(GO:0003677) |
| 0.1 | 28.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 26.4 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 26.2 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.4 | 26.0 | GO:0042805 | actinin binding(GO:0042805) |
| 5.0 | 25.0 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 2.4 | 19.4 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.1 | 17.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 15.5 | GO:0003774 | motor activity(GO:0003774) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 57.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 18.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.3 | 17.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 14.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 8.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 7.7 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 7.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.2 | PID ENDOTHELIN PATHWAY | Endothelins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 58.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.0 | 36.0 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 1.9 | 19.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 17.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 11.9 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.5 | 11.5 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.2 | 10.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 9.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 8.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 6.9 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |