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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU5F1_POU2F3
Z-value: 3.26
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F3 | hg38_v1_chr11_+_120236635_120236642, hg38_v1_chr11_+_120240135_120240199 | 0.33 | 6.7e-07 | Click! |
| POU5F1 | hg38_v1_chr6_-_31170620_31170698 | 0.20 | 3.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_89100352 Show fit | 92.63 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr2_+_90100235 Show fit | 90.54 |
ENST00000492446.1
|
immunoglobulin kappa variable 1D-16 |
|
| chr2_+_90021567 Show fit | 86.69 |
ENST00000436451.2
|
immunoglobulin kappa variable 6D-21 (non-functional) |
|
| chr2_+_90209873 Show fit | 86.58 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr2_-_88992903 Show fit | 85.21 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr2_+_90159840 Show fit | 83.58 |
ENST00000377032.5
|
immunoglobulin kappa variable 1D-12 |
|
| chr2_-_89160329 Show fit | 80.22 |
ENST00000390256.2
|
immunoglobulin kappa variable 6-21 (non-functional) |
|
| chr14_-_106593319 Show fit | 76.92 |
ENST00000390627.3
|
immunoglobulin heavy variable 3-53 |
|
| chr2_-_89040745 Show fit | 76.61 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr2_+_90069662 Show fit | 75.64 |
ENST00000390271.2
|
immunoglobulin kappa variable 6D-41 (non-functional) |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.7 | 2615.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 5.7 | 1007.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.7 | 188.3 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 10.0 | 129.9 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 10.4 | 83.2 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.3 | 75.8 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.6 | 71.3 | GO:0030183 | B cell differentiation(GO:0030183) |
| 11.4 | 57.2 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 7.0 | 49.3 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 6.4 | 44.5 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 1319.1 | GO:0005615 | extracellular space(GO:0005615) |
| 15.1 | 756.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 636.6 | GO:0005886 | plasma membrane(GO:0005886) |
| 3.4 | 610.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.0 | 196.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 10.0 | 129.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 33.5 | 100.5 | GO:0071754 | IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756) |
| 0.6 | 74.0 | GO:0016605 | PML body(GO:0016605) |
| 0.6 | 70.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.7 | 60.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 3656.9 | GO:0003823 | antigen binding(GO:0003823) |
| 12.5 | 261.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.4 | 116.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 8.4 | 75.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.3 | 64.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 11.2 | 55.9 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 2.9 | 48.7 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 1.6 | 45.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 6.2 | 43.7 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 10.6 | 42.4 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 271.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 2.3 | 116.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 3.6 | 83.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.5 | 63.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 1.5 | 61.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.8 | 60.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.9 | 49.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.8 | 34.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.0 | 31.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.5 | 26.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 261.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 4.8 | 129.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 2.9 | 76.5 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 2.1 | 70.1 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 2.4 | 55.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.5 | 54.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 54.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 43.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 2.9 | 34.6 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.9 | 34.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |