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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU6F1
Z-value: 0.73
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Transcription factors associated with POU6F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU6F1 | hg38_v1_chr12_-_51217671_51217827 | -0.54 | 7.3e-18 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU6F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_97960192 Show fit | 19.15 |
ENST00000496368.6
ENST00000421861.7 ENST00000357602.7 |
importin 5 |
|
| chr15_-_84716063 Show fit | 13.81 |
ENST00000558217.5
ENST00000558196.1 ENST00000558134.5 |
SEC11 homolog A, signal peptidase complex subunit |
|
| chr15_-_84716099 Show fit | 13.48 |
ENST00000560266.5
|
SEC11 homolog A, signal peptidase complex subunit |
|
| chr15_-_84716129 Show fit | 12.84 |
ENST00000268220.12
|
SEC11 homolog A, signal peptidase complex subunit |
|
| chr15_-_84716153 Show fit | 12.79 |
ENST00000455959.7
|
SEC11 homolog A, signal peptidase complex subunit |
|
| chr1_-_197146620 Show fit | 12.18 |
ENST00000367409.9
ENST00000680265.1 |
assembly factor for spindle microtubules |
|
| chrX_-_123622809 Show fit | 12.01 |
ENST00000441692.5
|
THO complex 2 |
|
| chrX_+_120604084 Show fit | 11.95 |
ENST00000371317.10
|
MCTS1 re-initiation and release factor |
|
| chr2_+_241350087 Show fit | 11.42 |
ENST00000451310.1
|
septin 2 |
|
| chr1_-_197146688 Show fit | 11.40 |
ENST00000294732.11
|
assembly factor for spindle microtubules |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 52.9 | GO:0006465 | signal peptide processing(GO:0006465) |
| 7.9 | 23.6 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 1.3 | 19.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 1.5 | 17.7 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 3.0 | 11.9 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.4 | 8.6 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 8.0 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.1 | 7.0 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.3 | 6.7 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 0.5 | 6.5 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 52.9 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 2.6 | 23.6 | GO:0036449 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 0.2 | 19.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 2.0 | 17.7 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.2 | 11.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 11.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 10.8 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 10.0 | GO:0005813 | centrosome(GO:0005813) |
| 0.8 | 8.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 7.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 52.9 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.1 | 22.7 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.8 | 19.1 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.2 | 13.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 11.8 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 8.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.2 | 6.7 | GO:0001848 | complement binding(GO:0001848) |
| 0.4 | 6.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.2 | 6.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.6 | 6.1 | GO:0005549 | odorant binding(GO:0005549) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 6.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.3 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 3.9 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 3.9 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 2.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 52.9 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 19.1 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.1 | 8.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 6.3 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.1 | 5.1 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.2 | 4.7 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.2 | 3.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 3.9 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 2.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.9 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |