ISMARA results: POU6F2

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for POU6F2

Z-value: 1.04

Motif logo

Transcription factors associated with POU6F2

Gene Symbol	Gene ID	Gene Info
POU6F2 Ensembl NCBI GeneCards UniProt	ENSG00000106536.21	POU6F2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU6F2	hg38_v1_chr7_+_38977904_38978009	0.40	9.2e-10	Click!

Activity profile of POU6F2 motif

Sorted Z-values of POU6F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr12_-_16606102 Show fit	31.68	ENST00000537304.6	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr12_-_16605939 Show fit	31.11	ENST00000541295.5 ENST00000535535.5	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chrX_-_13817027 Show fit	25.51	ENST00000493677.5 ENST00000355135.6 ENST00000316715.9	GPM6B Ensembl NCBI GeneCards UniProt Show fit	glycoprotein M6B
chr6_+_121437378 Show fit	24.24	ENST00000650427.1 ENST00000647564.1	GJA1 Ensembl NCBI GeneCards UniProt Show fit	gap junction protein alpha 1
chr1_+_50106265 Show fit	23.04	ENST00000357083.8	ELAVL4 Ensembl NCBI GeneCards UniProt Show fit	ELAV like RNA binding protein 4
chr2_+_200440649 Show fit	21.27	ENST00000366118.2	SPATS2L Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis associated serine rich 2 like
chr5_-_135578983 Show fit	20.86	ENST00000512158.6	CXCL14 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 14
chr14_-_20436161 Show fit	19.60	ENST00000636854.3	KLHL33 Ensembl NCBI GeneCards UniProt Show fit	kelch like family member 33
chr2_-_2324323 Show fit	19.59	ENST00000648339.1 ENST00000647694.1	MYT1L Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1 like
chr4_+_112860981 Show fit	19.34	ENST00000671704.1	ANK2 Ensembl NCBI GeneCards UniProt Show fit	ankyrin 2

Showing 1 to 10 of 121 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
12.5	87.7	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
5.7	56.9	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1	45.6	GO:0006397	mRNA processing(GO:0006397)
0.0	29.3	GO:0000122	negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
2.1	25.5	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
6.1	24.2	GO:0010645	regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.5	21.3	GO:0048665	neuron fate specification(GO:0048665)
3.5	20.9	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2	18.6	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.1	16.8	GO:0007258	JUN phosphorylation(GO:0007258)

Showing 1 to 10 of 67 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	67.2	GO:0043209	myelin sheath(GO:0043209)
1.0	59.8	GO:0043034	costamere(GO:0043034)
1.3	24.2	GO:0005922	connexon complex(GO:0005922)
0.1	22.1	GO:0001650	fibrillar center(GO:0001650)
0.3	21.0	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	17.1	GO:0043025	neuronal cell body(GO:0043025)
0.1	16.3	GO:0005901	caveola(GO:0005901)
1.2	10.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.5	9.6	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	9.2	GO:0045121	membrane raft(GO:0045121)

Showing 1 to 10 of 40 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	72.1	GO:0046872	metal ion binding(GO:0046872)
0.3	65.8	GO:0051015	actin filament binding(GO:0051015)
0.9	56.9	GO:0030507	spectrin binding(GO:0030507)
1.2	50.1	GO:0017091	AU-rich element binding(GO:0017091)
0.2	30.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	28.3	GO:0005096	GTPase activator activity(GO:0005096)
4.0	24.2	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.4	20.9	GO:0008009	chemokine activity(GO:0008009)
0.0	20.5	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
1.0	18.9	GO:0008179	adenylate cyclase binding(GO:0008179)

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	30.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	25.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.3	16.8	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2	15.2	PID FGF PATHWAY	FGF signaling pathway
0.0	11.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	7.5	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.1	7.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	3.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	2.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	2.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	24.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	18.6	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.2	18.4	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.4	10.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.2	9.8	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.2	9.6	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4	9.2	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.4	7.5	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.1	7.4	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.3	6.5	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle

Showing 1 to 10 of 26 entries

Results for POU6F2

Z-value: 1.04

Motif logo

Transcription factors associated with POU6F2

Activity-expression correlation:

Activity profile of POU6F2 motif

Sorted Z-values of POU6F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: