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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PPARA
Z-value: 1.16
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Transcription factors associated with PPARA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARA | hg38_v1_chr22_+_46150590_46150622 | -0.26 | 1.0e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_25906931 Show fit | 25.23 |
ENST00000357865.6
|
stathmin 1 |
|
| chr20_-_63499074 Show fit | 22.97 |
ENST00000217182.6
ENST00000642899.1 |
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr14_-_21024092 Show fit | 18.12 |
ENST00000554398.5
|
NDRG family member 2 |
|
| chr3_+_184337591 Show fit | 17.69 |
ENST00000383847.7
|
family with sequence similarity 131 member A |
|
| chr14_-_21023954 Show fit | 16.58 |
ENST00000554094.5
|
NDRG family member 2 |
|
| chr2_-_54987578 Show fit | 15.92 |
ENST00000486085.5
|
reticulon 4 |
|
| chr2_-_206159410 Show fit | 15.63 |
ENST00000457011.5
ENST00000440274.5 ENST00000432169.5 ENST00000233190.11 |
NADH:ubiquinone oxidoreductase core subunit S1 |
|
| chr2_-_175181663 Show fit | 14.93 |
ENST00000392541.3
ENST00000284727.9 ENST00000409194.5 |
ATP synthase membrane subunit c locus 3 |
|
| chr1_+_160127672 Show fit | 14.84 |
ENST00000447527.1
|
ATPase Na+/K+ transporting subunit alpha 2 |
|
| chr12_-_16606795 Show fit | 14.75 |
ENST00000447609.5
|
LIM domain only 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 111.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.7 | 50.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 7.1 | 50.0 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 2.5 | 45.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 2.4 | 41.1 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 1.3 | 36.0 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 2.4 | 34.3 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 2.1 | 31.1 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.8 | 29.7 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 2.7 | 29.4 | GO:0036376 | sodium ion export from cell(GO:0036376) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 77.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 56.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 3.7 | 48.4 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.2 | 42.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 39.5 | GO:0030427 | site of polarized growth(GO:0030427) |
| 3.2 | 34.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 6.9 | 34.5 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 2.1 | 32.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 32.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 3.3 | 29.8 | GO:0044327 | dendritic spine head(GO:0044327) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 112.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 46.5 | GO:0015631 | tubulin binding(GO:0015631) |
| 3.4 | 44.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 36.2 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 1.1 | 36.0 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 1.1 | 30.7 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 3.3 | 26.7 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.3 | 25.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.5 | 22.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.5 | 21.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 35.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.3 | 25.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 23.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 18.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.4 | 17.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.3 | 16.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.2 | 13.9 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 13.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 12.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 12.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 207.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.8 | 44.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.6 | 32.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 31.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 30.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 1.4 | 29.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 22.2 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.7 | 18.7 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.6 | 17.4 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.6 | 17.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |