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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PPARG
Z-value: 1.34
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Transcription factors associated with PPARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARG | hg38_v1_chr3_+_12289061_12289080 | -0.12 | 8.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 175.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 2.5 | 72.4 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.3 | 55.0 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 3.9 | 50.9 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 14.5 | 43.4 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 2.1 | 38.7 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 9.2 | 36.9 | GO:0002357 | defense response to tumor cell(GO:0002357) |
| 0.2 | 35.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 5.8 | 23.1 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 1.0 | 21.6 | GO:0060211 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 79.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 62.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 62.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 4.5 | 45.3 | GO:0044194 | cytolytic granule(GO:0044194) |
| 1.7 | 37.3 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.2 | 24.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 18.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 17.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.3 | 16.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 13.7 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 127.6 | GO:0003823 | antigen binding(GO:0003823) |
| 1.3 | 79.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 50.1 | GO:0005178 | integrin binding(GO:0005178) |
| 10.8 | 43.4 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 2.4 | 38.7 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.2 | 36.9 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 1.0 | 26.4 | GO:0022829 | wide pore channel activity(GO:0022829) |
| 0.1 | 25.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 25.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.4 | 23.1 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 55.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.9 | 36.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 23.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 23.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 18.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 13.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 13.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.3 | 12.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 11.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 10.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 90.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.5 | 52.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 19.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.8 | 18.3 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 17.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 15.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 15.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 11.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 10.6 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.7 | 10.0 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |