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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PRDM14
Z-value: 0.53
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Transcription factors associated with PRDM14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM14 | hg38_v1_chr8_-_70071226_70071258 | 0.09 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM14
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.5 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 1.1 | 19.5 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.7 | 14.5 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 7.5 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.1 | 7.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 6.5 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 1.1 | 5.6 | GO:2000814 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.6 | 4.4 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
| 0.1 | 3.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 2.8 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 18.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 16.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 8.7 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 7.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 6.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 5.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 5.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 3.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 2.8 | GO:0032433 | filopodium tip(GO:0032433) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 21.5 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.2 | 8.4 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 6.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 6.5 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 5.6 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
| 1.1 | 4.4 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.4 | 2.8 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.1 | 2.6 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.0 | 2.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.5 | 2.4 | GO:1990254 | keratin filament binding(GO:1990254) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 12.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 4.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.8 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.3 | 6.5 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.2 | 5.6 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 4.4 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
| 0.1 | 2.6 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 2.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.8 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 1.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |