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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PRDM4
Z-value: 0.65
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Transcription factors associated with PRDM4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM4 | hg38_v1_chr12_-_107761113_107761176 | -0.01 | 9.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_10723307 Show fit | 15.72 |
ENST00000279550.11
ENST00000228251.9 |
Y-box binding protein 3 |
|
| chr12_-_57846686 Show fit | 15.20 |
ENST00000548823.1
ENST00000398073.7 |
CTD small phosphatase 2 |
|
| chr1_-_224433776 Show fit | 13.23 |
ENST00000678879.1
ENST00000651911.2 |
WD repeat domain 26 |
|
| chr19_+_42220283 Show fit | 10.98 |
ENST00000301215.8
ENST00000597945.1 |
zinc finger protein 526 |
|
| chr14_+_105486867 Show fit | 9.88 |
ENST00000409393.6
ENST00000392531.4 |
cysteine rich protein 1 |
|
| chr2_+_218399838 Show fit | 8.00 |
ENST00000273062.7
|
CTD small phosphatase 1 |
|
| chr16_-_67936808 Show fit | 7.89 |
ENST00000358514.9
|
proteasome 20S subunit beta 10 |
|
| chr4_-_10116845 Show fit | 6.41 |
ENST00000382451.6
ENST00000382452.6 |
WD repeat domain 1 |
|
| chr7_+_143381907 Show fit | 6.25 |
ENST00000392910.6
|
zyxin |
|
| chr19_+_40611863 Show fit | 6.16 |
ENST00000601032.5
|
latent transforming growth factor beta binding protein 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.2 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 2.0 | 15.7 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 3.1 | 12.4 | GO:0042247 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 0.1 | 11.9 | GO:0043149 | integrin-mediated signaling pathway(GO:0007229) contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 2.5 | 9.9 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.1 | 7.5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.9 | 6.9 | GO:0003150 | muscular septum morphogenesis(GO:0003150) |
| 0.4 | 6.3 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.2 | 6.2 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.1 | 5.5 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.7 | GO:0005844 | polysome(GO:0005844) |
| 2.5 | 12.4 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.1 | 11.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 1.1 | 7.9 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 6.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 5.4 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 1.3 | 5.3 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.1 | 5.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 4.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 4.0 | GO:0031514 | motile cilium(GO:0031514) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 23.2 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.1 | 16.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 15.7 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.8 | 12.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.3 | 7.9 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 6.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 6.3 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.2 | 6.2 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
| 1.4 | 5.5 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.1 | 5.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 23.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.3 | 11.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 6.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 6.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.4 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 12.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 10.9 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 6.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 5.5 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 5.4 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 5.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 4.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 4.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 3.4 | REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |