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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PRDM4

Z-value: 0.65

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.12 PRDM4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg38_v1_chr12_-_107761113_107761176-0.019.3e-01Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_10723307 15.72 ENST00000279550.11
ENST00000228251.9
YBX3
Y-box binding protein 3
chr12_-_57846686 15.20 ENST00000548823.1
ENST00000398073.7
CTDSP2
CTD small phosphatase 2
chr1_-_224433776 13.23 ENST00000678879.1
ENST00000651911.2
WDR26
WD repeat domain 26
chr19_+_42220283 10.98 ENST00000301215.8
ENST00000597945.1
ZNF526
zinc finger protein 526
chr14_+_105486867 9.88 ENST00000409393.6
ENST00000392531.4
CRIP1
cysteine rich protein 1
chr2_+_218399838 8.00 ENST00000273062.7
CTDSP1
CTD small phosphatase 1
chr16_-_67936808 7.89 ENST00000358514.9
PSMB10
proteasome 20S subunit beta 10
chr4_-_10116845 6.41 ENST00000382451.6
ENST00000382452.6
WDR1
WD repeat domain 1
chr7_+_143381907 6.25 ENST00000392910.6
ZYX
zyxin
chr19_+_40611863 6.16 ENST00000601032.5
LTBP4
latent transforming growth factor beta binding protein 4
chr4_-_10116779 6.04 ENST00000499869.7
WDR1
WD repeat domain 1
chr20_+_62938111 5.66 ENST00000266069.5
GID8
GID complex subunit 8 homolog
chr7_+_143381561 5.63 ENST00000354434.8
ZYX
zyxin
chr21_+_33403391 5.55 ENST00000290219.11
ENST00000381995.5
IFNGR2
interferon gamma receptor 2
chr12_+_69585666 5.42 ENST00000543146.2
CCT2
chaperonin containing TCP1 subunit 2
chr17_+_44557476 5.22 ENST00000315323.5
FZD2
frizzled class receptor 2
chr2_+_233388146 4.67 ENST00000409813.7
DGKD
diacylglycerol kinase delta
chr15_-_66504832 4.09 ENST00000569438.2
ENST00000569696.5
ENST00000307961.11
RPL4
ribosomal protein L4
chr15_+_45023137 3.98 ENST00000674211.1
ENST00000267814.14
SORD
sorbitol dehydrogenase
chr14_-_95516616 3.89 ENST00000682763.1
SYNE3
spectrin repeat containing nuclear envelope family member 3
chr21_+_34073569 3.32 ENST00000399312.3
ENST00000381151.5
ENST00000362077.4
MRPS6
SLC5A3
ENSG00000272657.1
mitochondrial ribosomal protein S6
solute carrier family 5 member 3
novel transcript
chr6_-_32192630 3.28 ENST00000375040.8
GPSM3
G protein signaling modulator 3
chr4_+_673518 3.28 ENST00000506838.5
MYL5
myosin light chain 5
chr4_-_82373946 3.06 ENST00000352301.8
ENST00000509107.1
ENST00000353341.8
ENST00000313899.12
HNRNPD
heterogeneous nuclear ribonucleoprotein D
chr6_-_32192845 3.01 ENST00000487761.5
GPSM3
G protein signaling modulator 3
chr15_+_66505289 2.89 ENST00000565627.5
ENST00000564179.5
ENST00000307897.10
ZWILCH
zwilch kinetochore protein
chr9_+_93576557 2.63 ENST00000359246.9
ENST00000375376.8
PHF2
PHD finger protein 2
chr15_+_66504959 2.45 ENST00000535141.6
ENST00000613446.4
ENST00000446801.6
ZWILCH
zwilch kinetochore protein
chr10_-_103918128 2.37 ENST00000224950.8
STN1
STN1 subunit of CST complex
chr1_+_172533104 2.30 ENST00000616058.4
ENST00000263688.4
ENST00000610051.5
SUCO
SUN domain containing ossification factor
chr20_-_62937936 2.20 ENST00000266070.8
ENST00000370371.8
DIDO1
death inducer-obliterator 1
chr22_-_21002081 2.18 ENST00000215742.9
ENST00000399133.2
THAP7
THAP domain containing 7
chr5_-_181261078 2.12 ENST00000611618.1
TRIM52
tripartite motif containing 52
chr19_-_11529094 2.02 ENST00000588998.5
ENST00000586149.1
ECSIT
ECSIT signaling integrator
chr10_-_103452384 1.97 ENST00000369788.7
CALHM2
calcium homeostasis modulator family member 2
chr1_-_42766978 1.95 ENST00000372526.2
ENST00000236040.8
ENST00000296388.10
ENST00000397054.7
P3H1
prolyl 3-hydroxylase 1
chr1_+_42767241 1.91 ENST00000372525.7
C1orf50
chromosome 1 open reading frame 50
chr11_+_47257953 1.79 ENST00000437276.1
ENST00000436029.5
ENST00000467728.5
ENST00000441012.7
ENST00000405853.7
NR1H3
nuclear receptor subfamily 1 group H member 3
chr11_+_19117123 1.72 ENST00000399351.7
ENST00000446113.7
ZDHHC13
zinc finger DHHC-type palmitoyltransferase 13
chr7_+_91264426 1.70 ENST00000287934.4
FZD1
frizzled class receptor 1
chr5_+_159916475 1.44 ENST00000306675.5
ADRA1B
adrenoceptor alpha 1B
chr14_+_31561376 1.37 ENST00000550649.5
ENST00000281081.12
NUBPL
nucleotide binding protein like
chr19_-_11529116 1.25 ENST00000592312.5
ENST00000590480.1
ENST00000585318.5
ENST00000270517.12
ENST00000252440.11
ENST00000417981.6
ECSIT
ECSIT signaling integrator
chrX_+_49235460 1.24 ENST00000376227.4
CCDC22
coiled-coil domain containing 22
chr1_+_26787667 1.18 ENST00000674335.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr13_+_51861963 1.17 ENST00000242819.7
CCDC70
coiled-coil domain containing 70
chr1_+_218345326 1.17 ENST00000366930.9
TGFB2
transforming growth factor beta 2
chr2_+_203706475 1.08 ENST00000374481.7
ENST00000458610.6
CD28
CD28 molecule
chr1_+_26787926 0.96 ENST00000674202.1
ENST00000674222.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr16_+_14974974 0.92 ENST00000535621.6
ENST00000396410.9
ENST00000566426.1
PDXDC1
pyridoxal dependent decarboxylase domain containing 1
chr1_+_26788166 0.73 ENST00000374145.6
ENST00000431541.6
ENST00000674273.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr5_-_103120097 0.73 ENST00000508629.5
ENST00000399004.7
GIN1
gypsy retrotransposon integrase 1
chr15_-_35085295 0.47 ENST00000528386.4
NANOGP8
Nanog homeobox retrogene P8
chr10_+_122163590 0.43 ENST00000368999.5
TACC2
transforming acidic coiled-coil containing protein 2
chr12_+_15322480 0.34 ENST00000674188.1
ENST00000281171.9
ENST00000543886.6
PTPRO
protein tyrosine phosphatase receptor type O
chr17_+_7884783 0.26 ENST00000380358.9
CHD3
chromodomain helicase DNA binding protein 3
chr16_+_14975098 0.23 ENST00000569715.5
ENST00000627450.2
PDXDC1
pyridoxal dependent decarboxylase domain containing 1
chr4_+_673897 0.22 ENST00000505477.5
MYL5
myosin light chain 5
chr14_-_105065422 0.12 ENST00000329797.8
ENST00000539291.6
ENST00000392585.2
GPR132
G protein-coupled receptor 132
chrX_+_116436599 0.11 ENST00000598581.3
SLC6A14
solute carrier family 6 member 14
chr12_+_15322529 0.09 ENST00000348962.7
PTPRO
protein tyrosine phosphatase receptor type O
chr11_+_8019193 0.02 ENST00000534099.5
TUB
TUB bipartite transcription factor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.4 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
2.5 9.9 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
2.0 15.7 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
1.3 4.0 GO:0006059 hexitol metabolic process(GO:0006059)
1.1 3.3 GO:0015798 myo-inositol transport(GO:0015798)
1.0 3.1 GO:1901355 response to rapamycin(GO:1901355)
0.9 6.9 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.8 5.4 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.7 2.6 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.6 1.9 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.6 1.8 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.4 6.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.4 1.2 GO:0042704 uterine wall breakdown(GO:0042704)
0.4 1.4 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.3 3.9 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.2 4.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 6.2 GO:0030252 growth hormone secretion(GO:0030252)
0.1 5.5 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 2.9 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 23.2 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 0.4 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.7 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 2.3 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 7.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 2.4 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.1 1.1 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.1 11.9 GO:0043149 integrin-mediated signaling pathway(GO:0007229) contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.1 4.6 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.7 GO:0015074 DNA integration(GO:0015074)
0.0 5.3 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 4.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 3.5 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 2.1 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.4 GO:0042643 actomyosin, actin portion(GO:0042643)
1.3 5.3 GO:1990423 RZZ complex(GO:1990423)
1.1 7.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.6 2.4 GO:1990879 CST complex(GO:1990879)
0.5 2.9 GO:0031501 mannosyltransferase complex(GO:0031501)
0.4 5.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.3 3.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 15.7 GO:0005844 polysome(GO:0005844)
0.1 3.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 11.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.7 GO:1990909 Wnt signalosome(GO:1990909)
0.1 3.5 GO:0005859 muscle myosin complex(GO:0005859)
0.1 2.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 5.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 4.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 4.0 GO:0031514 motile cilium(GO:0031514)
0.0 2.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.1 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 6.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.4 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 23.2 GO:0008420 CTD phosphatase activity(GO:0008420)
1.4 5.5 GO:0004906 interferon-gamma receptor activity(GO:0004906)
1.0 2.9 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.8 12.9 GO:0003680 AT DNA binding(GO:0003680)
0.5 1.9 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.5 1.4 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.5 3.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.4 1.8 GO:0032810 sterol response element binding(GO:0032810)
0.3 6.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 7.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 4.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 6.2 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.2 6.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 1.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.4 GO:0043047 single-stranded telomeric DNA binding(GO:0043047)
0.1 5.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 15.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 1.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 2.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 1.2 GO:0097602 cullin family protein binding(GO:0097602)
0.1 16.3 GO:0051015 actin filament binding(GO:0051015)
0.0 3.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 4.0 GO:0051287 NAD binding(GO:0051287)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 3.3 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 1.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.1 GO:0015026 coreceptor activity(GO:0015026)
0.0 4.1 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 23.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 11.9 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 6.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 6.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.2 12.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 5.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 2.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 10.9 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 4.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 13.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 6.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 5.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 3.4 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 3.3 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 4.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation