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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PROX1
Z-value: 0.81
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Transcription factors associated with PROX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PROX1 | hg38_v1_chr1_+_213988501_213988549, hg38_v1_chr1_+_213987929_213987979 | 0.21 | 1.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PROX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_49529869 Show fit | 20.81 |
ENST00000361446.5
|
G antigen 12B |
|
| chr3_+_52410635 Show fit | 15.26 |
ENST00000327906.8
|
PHD finger protein 7 |
|
| chr2_+_86942118 Show fit | 11.80 |
ENST00000641458.2
|
RANBP2 like and GRIP domain containing 1 |
|
| chr3_+_158571215 Show fit | 10.24 |
ENST00000498592.6
ENST00000478894.7 |
myeloid leukemia factor 1 |
|
| chr4_+_127965394 Show fit | 7.54 |
ENST00000645843.2
ENST00000388795.9 |
abhydrolase domain containing 18 |
|
| chr11_-_72434604 Show fit | 7.02 |
ENST00000543042.6
|
caseinolytic mitochondrial matrix peptidase chaperone subunit B |
|
| chr15_-_58065703 Show fit | 6.69 |
ENST00000249750.9
|
aldehyde dehydrogenase 1 family member A2 |
|
| chr13_-_36214521 Show fit | 6.50 |
ENST00000379881.8
|
spermatogenesis and oogenesis specific basic helix-loop-helix 2 |
|
| chr2_-_106468326 Show fit | 6.19 |
ENST00000304514.11
ENST00000409886.4 |
RANBP2 like and GRIP domain containing 3 |
|
| chr15_-_58065734 Show fit | 6.02 |
ENST00000347587.7
|
aldehyde dehydrogenase 1 family member A2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 21.4 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.1 | 18.7 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.6 | 18.0 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 1.4 | 12.7 | GO:0042904 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.3 | 9.5 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 1.8 | 9.0 | GO:0034721 | histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721) |
| 0.0 | 7.1 | GO:0007051 | spindle organization(GO:0007051) |
| 0.1 | 6.5 | GO:0048477 | oogenesis(GO:0048477) |
| 0.0 | 6.4 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 1.1 | 5.4 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.8 | 5.6 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.2 | 5.4 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.3 | 5.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.6 | 5.1 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 5.0 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 4.7 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 4.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 4.0 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 3.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.2 | GO:0016887 | ATPase activity(GO:0016887) |
| 0.0 | 13.2 | GO:0019904 | protein domain specific binding(GO:0019904) |
| 1.1 | 12.7 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.0 | 11.1 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.3 | 9.5 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 1.8 | 9.0 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.0 | 8.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 7.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 5.8 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.9 | 5.4 | GO:0003796 | lysozyme activity(GO:0003796) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 4.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 4.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 3.3 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 2.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.3 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 2.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 1.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.6 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 5.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 4.2 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 4.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 4.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 3.6 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 3.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 2.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 2.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |