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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PRRX1_ALX4_PHOX2A
Z-value: 0.87
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Transcription factors associated with PRRX1_ALX4_PHOX2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PHOX2A | hg38_v1_chr11_-_72241192_72241275, hg38_v1_chr11_-_72244166_72244184 | -0.12 | 7.4e-02 | Click! |
| PRRX1 | hg38_v1_chr1_+_170664121_170664144 | 0.10 | 1.5e-01 | Click! |
| ALX4 | hg38_v1_chr11_-_44310126_44310152 | 0.09 | 1.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRRX1_ALX4_PHOX2A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.9 | 87.5 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.3 | 59.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.8 | 35.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 3.0 | 30.2 | GO:0009449 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 9.6 | 28.9 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 3.6 | 25.2 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 5.5 | 22.0 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 0.4 | 19.0 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.8 | 16.6 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.2 | 16.0 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 87.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 59.1 | GO:0043025 | neuronal cell body(GO:0043025) |
| 1.5 | 36.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 22.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 22.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 18.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 17.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 16.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.7 | 14.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 3.5 | 14.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 87.5 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.1 | 54.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 36.4 | GO:0005262 | calcium channel activity(GO:0005262) |
| 2.2 | 30.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.7 | 28.9 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 23.3 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.9 | 22.0 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.5 | 20.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.5 | 19.1 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.1 | 17.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 88.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 14.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 13.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 12.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 10.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 9.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 7.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 7.3 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 6.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 6.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 87.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.4 | 29.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.7 | 22.0 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.5 | 20.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.5 | 14.7 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 11.1 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 10.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 8.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 8.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 7.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |