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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PTF1A

Z-value: 0.81

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Transcription factors associated with PTF1A

Gene Symbol Gene ID Gene Info
PTF1A
ENSG00000168267.7 PTF1A

Activity profile of PTF1A motif

Sorted Z-values of PTF1A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PTF1A

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_111923722 16.07 ENST00000527950.5
CRYAB
crystallin alpha B
chr2_-_71227055 13.62 ENST00000244221.9
PAIP2B
poly(A) binding protein interacting protein 2B
chr8_-_98294195 12.79 ENST00000430223.7
NIPAL2
NIPA like domain containing 2
chr11_+_6863057 12.05 ENST00000641461.1
OR10A2
olfactory receptor family 10 subfamily A member 2
chr10_-_122845850 10.00 ENST00000392790.6
CUZD1
CUB and zona pellucida like domains 1
chr8_-_98294339 9.98 ENST00000341166.3
NIPAL2
NIPA like domain containing 2
chr2_-_135530561 8.66 ENST00000536680.5
ENST00000401392.5
ZRANB3
zinc finger RANBP2-type containing 3
chr8_-_22232020 8.22 ENST00000454243.7
ENST00000321613.7
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr3_+_101827982 8.13 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKBIZ
NFKB inhibitor zeta
chr19_-_9219589 7.72 ENST00000641244.1
ENST00000641669.1
OR7D4
olfactory receptor family 7 subfamily D member 4
chr14_-_106875069 7.70 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr7_-_152676130 7.43 ENST00000359321.2
XRCC2
X-ray repair cross complementing 2
chr5_-_118988504 7.32 ENST00000515439.7
ENST00000510708.6
DTWD2
DTW domain containing 2
chr7_+_142760398 7.07 ENST00000632998.1
PRSS2
serine protease 2
chr4_+_155666718 6.67 ENST00000621234.4
ENST00000511108.5
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr2_+_172735838 6.63 ENST00000397081.8
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr2_-_159904668 6.54 ENST00000504764.5
ENST00000505052.1
ENST00000263636.5
LY75-CD302
LY75
LY75-CD302 readthrough
lymphocyte antigen 75
chr17_-_75896911 6.49 ENST00000540128.1
ENST00000269383.8
TRIM65
tripartite motif containing 65
chr17_-_35986649 6.23 ENST00000622526.1
ENST00000620991.1
ENST00000618404.5
CCL14
C-C motif chemokine ligand 14
chr15_+_79311137 5.95 ENST00000424155.6
ENST00000536821.5
TMED3
transmembrane p24 trafficking protein 3
chr4_-_82798735 5.85 ENST00000273908.4
ENST00000319540.9
SCD5
stearoyl-CoA desaturase 5
chr8_-_109648825 5.85 ENST00000533895.5
ENST00000446070.6
ENST00000528331.5
ENST00000526302.5
ENST00000408908.6
ENST00000433638.1
ENST00000524720.5
SYBU
syntabulin
chr11_+_73646558 5.80 ENST00000536527.5
ENST00000354190.10
PLEKHB1
pleckstrin homology domain containing B1
chr3_+_48990219 5.71 ENST00000383729.9
P4HTM
prolyl 4-hydroxylase, transmembrane
chr4_+_40197023 5.70 ENST00000381799.10
RHOH
ras homolog family member H
chr3_+_48989876 5.48 ENST00000343546.8
P4HTM
prolyl 4-hydroxylase, transmembrane
chr2_-_89213917 5.42 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr4_+_155666963 5.42 ENST00000455639.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr1_-_9069608 5.38 ENST00000377424.9
SLC2A5
solute carrier family 2 member 5
chr10_-_28282086 5.38 ENST00000375719.7
ENST00000375732.5
MPP7
membrane palmitoylated protein 7
chr3_+_167735704 5.31 ENST00000446050.7
ENST00000295777.9
ENST00000472747.2
SERPINI1
serpin family I member 1
chr1_+_113905156 5.30 ENST00000650596.1
DCLRE1B
DNA cross-link repair 1B
chr18_-_55510753 5.11 ENST00000543082.5
TCF4
transcription factor 4
chr7_+_142750657 5.10 ENST00000492062.1
PRSS1
serine protease 1
chr6_-_62286161 5.07 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr4_+_155666827 5.05 ENST00000511507.5
ENST00000506455.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr2_-_196068812 4.86 ENST00000410072.5
ENST00000312428.11
DNAH7
dynein axonemal heavy chain 7
chr2_+_183078736 4.80 ENST00000354221.5
DUSP19
dual specificity phosphatase 19
chr10_+_75111595 4.74 ENST00000671800.1
ENST00000542569.6
ENST00000372687.4
SAMD8
sterile alpha motif domain containing 8
chr11_-_207221 4.62 ENST00000486280.1
ENST00000332865.10
ENST00000529614.6
ENST00000325147.13
ENST00000410108.5
ENST00000382762.7
BET1L
Bet1 golgi vesicular membrane trafficking protein like
chr4_+_40196907 4.51 ENST00000622175.4
ENST00000619474.4
ENST00000615083.4
ENST00000610353.4
ENST00000614836.1
RHOH
ras homolog family member H
chr4_-_86357722 4.43 ENST00000641341.1
ENST00000642038.1
ENST00000641116.1
ENST00000641767.1
ENST00000639242.1
ENST00000638313.1
MAPK10
mitogen-activated protein kinase 10
chr19_-_46023046 4.40 ENST00000008938.5
PGLYRP1
peptidoglycan recognition protein 1
chr3_+_35639589 4.32 ENST00000428373.5
ARPP21
cAMP regulated phosphoprotein 21
chr22_-_50085331 4.24 ENST00000395876.6
MLC1
modulator of VRAC current 1
chr7_-_101200912 4.23 ENST00000440203.6
ENST00000379423.3
ENST00000223114.9
MOGAT3
monoacylglycerol O-acyltransferase 3
chr7_-_29146436 4.14 ENST00000396276.7
CPVL
carboxypeptidase vitellogenic like
chr11_-_96389857 4.12 ENST00000680532.1
ENST00000681014.1
ENST00000679708.1
ENST00000645439.1
ENST00000645366.1
ENST00000680728.1
ENST00000680859.1
ENST00000679788.1
ENST00000681164.1
ENST00000646818.2
ENST00000680171.1
ENST00000679696.1
ENST00000681200.1
ENST00000679960.1
ENST00000647080.1
ENST00000646050.1
ENST00000681451.1
ENST00000644686.1
ENST00000680052.1
ENST00000679616.1
ENST00000530203.2
CCDC82
coiled-coil domain containing 82
chr12_+_75391078 4.12 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1L2
GLIPR1 like 2
chr9_+_33795551 3.93 ENST00000379405.4
PRSS3
serine protease 3
chr6_-_24877262 3.91 ENST00000378023.8
ENST00000540914.5
RIPOR2
RHO family interacting cell polarization regulator 2
chr1_+_113905290 3.87 ENST00000650450.2
DCLRE1B
DNA cross-link repair 1B
chr9_+_4985227 3.82 ENST00000381652.4
JAK2
Janus kinase 2
chr19_+_9178979 3.82 ENST00000642043.1
ENST00000641288.2
OR7D2
olfactory receptor family 7 subfamily D member 2
chr7_-_22356914 3.82 ENST00000344041.10
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr11_+_96389985 3.66 ENST00000332349.5
JRKL
JRK like
chr17_+_55264952 3.65 ENST00000226067.10
HLF
HLF transcription factor, PAR bZIP family member
chr16_+_89630263 3.59 ENST00000261615.5
DPEP1
dipeptidase 1
chr19_+_41755520 3.52 ENST00000199764.7
CEACAM6
CEA cell adhesion molecule 6
chr12_+_112906949 3.49 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
OAS1
2'-5'-oligoadenylate synthetase 1
chr12_+_112907006 3.48 ENST00000680455.1
ENST00000551241.6
ENST00000550689.2
ENST00000679841.1
ENST00000679494.1
ENST00000553185.2
OAS1
2'-5'-oligoadenylate synthetase 1
chr1_-_45491150 3.46 ENST00000372086.4
TESK2
testis associated actin remodelling kinase 2
chr7_+_142749465 3.38 ENST00000486171.5
ENST00000619214.4
ENST00000311737.12
PRSS1
serine protease 1
chr10_+_97572493 3.37 ENST00000307518.9
ENST00000298808.9
ANKRD2
ankyrin repeat domain 2
chr3_+_35679614 3.31 ENST00000474696.5
ENST00000412048.5
ENST00000396482.6
ENST00000432682.5
ARPP21
cAMP regulated phosphoprotein 21
chr12_+_112906777 3.28 ENST00000452357.7
ENST00000445409.7
OAS1
2'-5'-oligoadenylate synthetase 1
chr13_-_20525796 3.27 ENST00000298248.12
ENST00000382812.5
ENST00000644593.1
ENST00000643750.1
CRYL1
crystallin lambda 1
chr20_-_46513516 3.25 ENST00000347606.8
ENST00000625284.2
ENST00000457685.6
ZNF334
zinc finger protein 334
chr7_-_22357112 3.23 ENST00000405243.1
ENST00000665637.1
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr11_-_45665578 3.21 ENST00000308064.7
CHST1
carbohydrate sulfotransferase 1
chr20_+_46008900 3.18 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chrX_+_15790446 3.16 ENST00000380308.7
ENST00000307771.8
ZRSR2
zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
chr17_+_69502397 3.11 ENST00000613873.4
ENST00000589647.5
MAP2K6
mitogen-activated protein kinase kinase 6
chr1_-_75611083 3.09 ENST00000370855.5
SLC44A5
solute carrier family 44 member 5
chr15_-_89221558 3.08 ENST00000268125.10
RLBP1
retinaldehyde binding protein 1
chr13_+_31945826 3.00 ENST00000647500.1
FRY
FRY microtubule binding protein
chr19_+_29665444 2.88 ENST00000592810.1
ENST00000436066.4
PLEKHF1
pleckstrin homology and FYVE domain containing 1
chr4_-_107036302 2.87 ENST00000285311.8
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr7_-_29146527 2.87 ENST00000265394.10
CPVL
carboxypeptidase vitellogenic like
chr9_-_101383558 2.68 ENST00000674556.1
BAAT
bile acid-CoA:amino acid N-acyltransferase
chr17_-_3557798 2.67 ENST00000301365.8
ENST00000572519.1
ENST00000576742.6
TRPV3
transient receptor potential cation channel subfamily V member 3
chr4_-_88823165 2.67 ENST00000508369.5
FAM13A
family with sequence similarity 13 member A
chr19_+_17215716 2.66 ENST00000593597.1
USE1
unconventional SNARE in the ER 1
chr1_-_158331522 2.49 ENST00000368168.4
CD1B
CD1b molecule
chr2_-_70768175 2.48 ENST00000355733.7
ENST00000447731.6
ENST00000430656.5
ENST00000264436.9
ENST00000413157.6
ADD2
adducin 2
chr12_-_21941402 2.47 ENST00000326684.8
ENST00000682068.1
ENST00000621589.2
ENST00000261200.9
ENST00000683676.1
ABCC9
ATP binding cassette subfamily C member 9
chr12_-_48004496 2.46 ENST00000337299.7
COL2A1
collagen type II alpha 1 chain
chr4_-_88823214 2.43 ENST00000513837.5
ENST00000503556.5
FAM13A
family with sequence similarity 13 member A
chr20_+_50731571 2.41 ENST00000371610.7
PARD6B
par-6 family cell polarity regulator beta
chr1_-_20119527 2.37 ENST00000375105.8
ENST00000617227.1
PLA2G2D
phospholipase A2 group IID
chr2_-_236503688 2.37 ENST00000418802.2
ENST00000431676.6
IQCA1
IQ motif containing with AAA domain 1
chr3_-_155745016 2.33 ENST00000460012.7
PLCH1
phospholipase C eta 1
chr8_-_124565699 2.27 ENST00000519168.5
MTSS1
MTSS I-BAR domain containing 1
chr1_+_157993601 2.26 ENST00000359209.11
KIRREL1
kirre like nephrin family adhesion molecule 1
chr19_-_5867741 2.22 ENST00000252675.6
FUT5
fucosyltransferase 5
chr9_-_111036207 2.21 ENST00000541779.5
LPAR1
lysophosphatidic acid receptor 1
chr1_-_158330957 2.19 ENST00000451207.5
CD1B
CD1b molecule
chr7_-_37916807 2.18 ENST00000436072.7
SFRP4
secreted frizzled related protein 4
chr1_-_230978796 2.17 ENST00000522821.5
ENST00000366662.8
ENST00000366661.9
ENST00000522399.1
TTC13
tetratricopeptide repeat domain 13
chr1_-_204685700 2.10 ENST00000367177.4
LRRN2
leucine rich repeat neuronal 2
chr1_+_157993273 2.08 ENST00000360089.8
ENST00000368173.7
KIRREL1
kirre like nephrin family adhesion molecule 1
chr22_+_24603147 1.97 ENST00000412658.5
ENST00000445029.5
ENST00000400382.6
ENST00000419133.5
ENST00000438643.6
ENST00000452551.5
ENST00000412898.5
ENST00000400380.5
ENST00000455483.5
ENST00000430289.5
GGT1
gamma-glutamyltransferase 1
chrX_-_11665908 1.92 ENST00000337414.9
ARHGAP6
Rho GTPase activating protein 6
chr16_+_2752622 1.89 ENST00000576924.5
ENST00000575009.5
ENST00000301740.13
ENST00000630499.2
ENST00000576415.5
ENST00000571378.5
SRRM2
serine/arginine repetitive matrix 2
chr8_+_11494367 1.87 ENST00000259089.9
ENST00000529894.1
BLK
BLK proto-oncogene, Src family tyrosine kinase
chr14_-_106025628 1.74 ENST00000631943.1
IGHV7-4-1
immunoglobulin heavy variable 7-4-1
chr13_-_79405784 1.61 ENST00000267229.11
RBM26
RNA binding motif protein 26
chr12_-_48004467 1.54 ENST00000380518.8
COL2A1
collagen type II alpha 1 chain
chr12_-_21941300 1.51 ENST00000684084.1
ABCC9
ATP binding cassette subfamily C member 9
chr2_+_96760857 1.46 ENST00000377075.3
CNNM4
cyclin and CBS domain divalent metal cation transport mediator 4
chr16_-_1954682 1.41 ENST00000268661.8
RPL3L
ribosomal protein L3 like
chr8_+_49911396 1.40 ENST00000642720.2
SNTG1
syntrophin gamma 1
chrX_+_155071414 1.40 ENST00000340647.8
BRCC3
BRCA1/BRCA2-containing complex subunit 3
chr16_+_71358713 1.28 ENST00000349553.9
ENST00000302628.9
ENST00000562305.5
CALB2
calbindin 2
chr11_-_102705737 1.15 ENST00000260229.5
MMP27
matrix metallopeptidase 27
chr16_-_65121930 1.15 ENST00000566827.5
ENST00000394156.7
ENST00000268603.9
ENST00000562998.1
CDH11
cadherin 11
chr4_+_81030700 1.08 ENST00000282701.4
BMP3
bone morphogenetic protein 3
chr4_-_174829212 1.04 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr8_+_32548267 1.03 ENST00000356819.7
NRG1
neuregulin 1
chr1_+_26529745 0.92 ENST00000374168.7
ENST00000374166.8
RPS6KA1
ribosomal protein S6 kinase A1
chr21_+_33205279 0.86 ENST00000683941.1
IFNAR2
interferon alpha and beta receptor subunit 2
chr2_+_43838963 0.80 ENST00000272286.4
ABCG8
ATP binding cassette subfamily G member 8
chr7_-_99500240 0.80 ENST00000426306.2
ENST00000337673.7
ZNF394
zinc finger protein 394
chr2_+_201257980 0.78 ENST00000447616.5
ENST00000358485.8
ENST00000392266.7
CASP8
caspase 8
chr16_-_46689145 0.77 ENST00000299138.12
VPS35
VPS35 retromer complex component
chr20_+_56248732 0.72 ENST00000243911.2
MC3R
melanocortin 3 receptor
chr7_-_93574721 0.65 ENST00000426151.7
ENST00000649521.1
CALCR
calcitonin receptor
chr20_-_3663399 0.64 ENST00000290417.7
ENST00000319242.8
GFRA4
GDNF family receptor alpha 4
chr6_-_56394094 0.62 ENST00000370819.5
COL21A1
collagen type XXI alpha 1 chain
chr3_-_12841527 0.49 ENST00000396953.6
ENST00000457131.1
ENST00000435983.5
ENST00000273223.10
ENST00000429711.7
ENST00000396957.5
RPL32
ribosomal protein L32
chr7_-_5513738 0.44 ENST00000453700.7
ENST00000382368.8
FBXL18
F-box and leucine rich repeat protein 18
chr12_+_112013418 0.44 ENST00000261735.4
ENST00000552052.1
ERP29
endoplasmic reticulum protein 29
chr2_+_85695368 0.30 ENST00000526018.1
GNLY
granulysin
chr19_+_54573781 0.29 ENST00000391738.8
ENST00000251376.7
ENST00000391737.3
ENST00000629481.1
LILRA2
leukocyte immunoglobulin like receptor A2
chr14_-_106470788 0.27 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr5_+_141177790 0.24 ENST00000239444.4
ENST00000623995.1
PCDHB8
ENSG00000279472.1
protocadherin beta 8
novel transcript
chr6_-_24489565 0.22 ENST00000230036.2
GPLD1
glycosylphosphatidylinositol specific phospholipase D1
chr4_-_122922442 0.15 ENST00000510735.1
ENST00000304430.10
NUDT6
nudix hydrolase 6
chr4_-_88823306 0.11 ENST00000395002.6
FAM13A
family with sequence similarity 13 member A
chr6_-_41747390 0.04 ENST00000356667.8
ENST00000373025.7
ENST00000425343.6
PGC
progastricsin
chr12_+_50057548 0.02 ENST00000228468.8
ENST00000447966.7
ASIC1
acid sensing ion channel subunit 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0036292 DNA rewinding(GO:0036292)
2.5 22.8 GO:0015693 magnesium ion transport(GO:0015693)
2.3 9.2 GO:0031627 telomeric loop formation(GO:0031627)
1.7 10.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
1.5 4.4 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
1.3 3.8 GO:1902724 mineralocorticoid receptor signaling pathway(GO:0031959) regulation of growth hormone receptor signaling pathway(GO:0060398) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
1.2 7.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
1.2 3.6 GO:0016999 antibiotic metabolic process(GO:0016999) cellular amide catabolic process(GO:0043605)
1.0 3.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.9 16.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.9 5.4 GO:0071896 protein localization to adherens junction(GO:0071896)
0.8 3.9 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.8 0.8 GO:1903179 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.7 3.0 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.7 2.2 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.6 4.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.5 3.3 GO:0051167 glucuronate catabolic process(GO:0006064) glucuronate catabolic process to xylulose 5-phosphate(GO:0019640) xylulose 5-phosphate metabolic process(GO:0051167) xylulose 5-phosphate biosynthetic process(GO:1901159)
0.5 2.4 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.5 2.3 GO:0030035 microspike assembly(GO:0030035)
0.4 2.7 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.4 12.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.4 2.2 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.4 13.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.4 4.7 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.4 3.2 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.3 4.9 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 4.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 0.8 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.3 3.1 GO:0015871 choline transport(GO:0015871)
0.2 2.0 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.2 4.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.2 4.0 GO:0060174 limb bud formation(GO:0060174)
0.2 22.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 2.7 GO:0019530 taurine metabolic process(GO:0019530)
0.2 4.5 GO:0071397 cellular response to cholesterol(GO:0071397)
0.2 3.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.2 3.4 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) regulation of myoblast proliferation(GO:2000291)
0.2 4.2 GO:0006071 glycerol metabolic process(GO:0006071)
0.2 0.8 GO:0039650 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.2 2.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.2 11.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.2 1.5 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.2 3.2 GO:0006012 galactose metabolic process(GO:0006012)
0.2 10.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 0.9 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 1.0 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 8.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 6.2 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 10.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 0.3 GO:0002818 intracellular defense response(GO:0002818)
0.1 5.9 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.1 2.5 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 8.2 GO:0030574 collagen catabolic process(GO:0030574)
0.1 5.8 GO:0007602 phototransduction(GO:0007602)
0.1 1.2 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.1 7.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.5 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.1 6.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 0.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 5.8 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 4.0 GO:0010107 potassium ion import(GO:0010107)
0.1 1.9 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 1.9 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
0.1 0.6 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 5.3 GO:0007422 peripheral nervous system development(GO:0007422)
0.1 6.3 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 0.9 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 3.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 3.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.7 GO:0045475 locomotor rhythm(GO:0045475)
0.0 5.1 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 2.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:1990539 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 1.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 2.8 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 5.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 4.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.9 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 2.3 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 2.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 5.1 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 1.1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 12.2 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 3.5 GO:0030335 positive regulation of cell migration(GO:0030335)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.4 GO:0033061 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
1.0 16.1 GO:0097512 cardiac myofibril(GO:0097512)
0.8 4.7 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.6 3.2 GO:0089701 U2AF(GO:0089701)
0.6 4.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.5 10.0 GO:0042589 zymogen granule membrane(GO:0042589)
0.4 4.9 GO:0005858 axonemal dynein complex(GO:0005858)
0.4 5.8 GO:0097433 dense body(GO:0097433)
0.4 3.9 GO:0060171 stereocilium membrane(GO:0060171)
0.3 4.0 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 5.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.3 0.8 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 2.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 10.2 GO:0001772 immunological synapse(GO:0001772)
0.2 1.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 8.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 4.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.5 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.4 GO:0016013 syntrophin complex(GO:0016013)
0.1 5.9 GO:0043596 nuclear replication fork(GO:0043596)
0.1 3.4 GO:0000791 euchromatin(GO:0000791)
0.1 0.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 0.8 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 9.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 3.8 GO:0031904 endosome lumen(GO:0031904)
0.1 8.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 7.1 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.5 GO:0070552 BRISC complex(GO:0070552)
0.1 3.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 8.5 GO:0072562 blood microparticle(GO:0072562)
0.0 2.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 6.3 GO:0043204 perikaryon(GO:0043204)
0.0 2.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 5.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.8 GO:0097342 ripoptosome(GO:0097342)
0.0 2.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.7 GO:0005901 caveola(GO:0005901)
0.0 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.1 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.0 GO:0000922 spindle pole(GO:0000922)
0.0 2.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 74.8 GO:0016021 integral component of membrane(GO:0016021)
0.0 1.3 GO:0043195 terminal bouton(GO:0043195)
0.0 3.1 GO:0044297 cell body(GO:0044297)
0.0 1.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.6 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
1.5 5.9 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
1.4 24.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
1.4 4.2 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
1.1 3.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.1 4.4 GO:0016019 peptidoglycan receptor activity(GO:0016019)
1.0 3.1 GO:0005502 11-cis retinal binding(GO:0005502)
1.0 4.0 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.9 2.7 GO:0052816 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.8 3.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.8 10.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.8 8.7 GO:0036310 annealing helicase activity(GO:0036310)
0.8 3.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.7 3.6 GO:0070573 metallodipeptidase activity(GO:0070573)
0.6 13.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.6 3.8 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.6 4.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 16.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.5 4.7 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.5 7.0 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.5 7.4 GO:0000150 recombinase activity(GO:0000150)
0.5 3.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.4 10.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.4 2.2 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.3 4.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 4.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 7.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 4.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.3 2.9 GO:0039706 co-receptor binding(GO:0039706)
0.2 2.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 5.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 2.9 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 0.7 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 2.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 3.3 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.2 22.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 1.0 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 0.9 GO:0004905 type I interferon receptor activity(GO:0004905)
0.2 5.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 5.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 0.7 GO:0004948 calcitonin receptor activity(GO:0004948)
0.2 2.0 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 6.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 8.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.8 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 6.6 GO:0030552 cAMP binding(GO:0030552)
0.1 1.1 GO:0070700 BMP receptor binding(GO:0070700)
0.1 3.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 4.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 11.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 2.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 12.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.8 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.8 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 1.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 6.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 6.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.7 GO:0005262 calcium channel activity(GO:0005262)
0.0 7.1 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 3.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 7.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.1 4.4 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 21.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 5.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 2.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 18.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 22.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 3.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 6.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 2.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 4.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 2.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 3.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.1 3.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 4.8 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 11.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.2 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 17.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 4.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 1.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.2 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events