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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RAD21_SMC3
Z-value: 0.89
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Transcription factors associated with RAD21_SMC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMC3 | hg38_v1_chr10_+_110567666_110567765 | -0.47 | 1.4e-13 | Click! |
| RAD21 | hg38_v1_chr8_-_116874746_116874828 | -0.35 | 1.4e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RAD21_SMC3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.2 | 39.6 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 4.3 | 26.1 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 5.8 | 23.4 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 2.7 | 19.0 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 0.6 | 18.6 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.9 | 16.7 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.4 | 16.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 5.1 | 15.3 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 0.7 | 14.8 | GO:0021756 | striatum development(GO:0021756) |
| 0.2 | 14.1 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 46.9 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 36.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 2.3 | 34.1 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.1 | 32.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.2 | 30.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 2.6 | 26.1 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.4 | 20.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 15.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 15.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.4 | 14.7 | GO:0033268 | node of Ranvier(GO:0033268) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 65.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 42.2 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.6 | 27.5 | GO:1990939 | ATP-dependent microtubule motor activity(GO:1990939) |
| 0.8 | 26.3 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 24.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.8 | 19.0 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.3 | 16.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 3.8 | 15.3 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.7 | 14.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 13.6 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 40.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 21.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 20.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 17.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 17.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 16.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.7 | 14.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 14.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 12.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 9.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 40.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 1.9 | 39.6 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 15.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.4 | 15.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 12.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 12.1 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.3 | 12.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 10.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 10.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 10.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |