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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RARB
Z-value: 0.95
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Transcription factors associated with RARB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARB | hg38_v1_chr3_+_25428233_25428284 | 0.62 | 1.1e-24 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RARB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 27.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.5 | 24.6 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 1.2 | 21.1 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.0 | 18.5 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.9 | 17.9 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 5.7 | 17.0 | GO:0014873 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873) |
| 0.3 | 16.7 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 13.0 | GO:0007186 | G-protein coupled receptor signaling pathway(GO:0007186) |
| 1.1 | 12.4 | GO:0034371 | chylomicron remodeling(GO:0034371) |
| 1.6 | 11.2 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 89.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.7 | 27.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 21.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.3 | 20.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 17.9 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 16.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 13.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.8 | 12.4 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.2 | 12.3 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.5 | 10.9 | GO:0010369 | chromocenter(GO:0010369) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 41.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.1 | 31.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.9 | 21.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.6 | 20.4 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 2.1 | 18.5 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.9 | 17.0 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.6 | 12.9 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.1 | 11.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 11.2 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.4 | 10.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 17.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.4 | 17.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 12.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 10.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 7.6 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 7.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.3 | 6.7 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 4.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 43.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.4 | 21.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 20.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 19.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.6 | 12.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 7.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 7.0 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 6.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 6.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 6.5 | REACTOME KINESINS | Genes involved in Kinesins |