ISMARA results: RARG

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RARG

Z-value: 1.19

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Transcription factors associated with RARG

Gene Symbol	Gene ID	Gene Info
RARG Ensembl NCBI GeneCards UniProt	ENSG00000172819.17	RARG

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RARG	hg38_v1_chr12_-_53232182_53232256	-0.11	1.1e-01	Click!

Activity profile of RARG motif

Sorted Z-values of RARG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RARG

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Promoter	Score	Transcript	Gene	Gene Info
chr7_-_10940123 Show fit	19.96	ENST00000339600.6	NDUFA4 Ensembl NCBI GeneCards UniProt Show fit	NDUFA4 mitochondrial complex associated
chrX_+_103585478 Show fit	15.93	ENST00000468024.5 ENST00000415568.2 ENST00000472484.6 ENST00000613326.4 ENST00000490644.5 ENST00000459722.1 ENST00000472745.1 ENST00000494801.5 ENST00000434216.2	TCEAL4 Ensembl NCBI GeneCards UniProt Show fit	transcription elongation factor A like 4
chr20_-_63499074 Show fit	15.91	ENST00000217182.6 ENST00000642899.1	EEF1A2 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation elongation factor 1 alpha 2
chr9_-_127874964 Show fit	14.86	ENST00000373156.5	AK1 Ensembl NCBI GeneCards UniProt Show fit	adenylate kinase 1
chr7_+_128758947 Show fit	14.35	ENST00000493278.1	CALU Ensembl NCBI GeneCards UniProt Show fit	calumenin
chr2_-_86563382 Show fit	12.88	ENST00000263856.9	CHMP3 Ensembl NCBI GeneCards UniProt Show fit	charged multivesicular body protein 3
chr1_+_44746401 Show fit	12.16	ENST00000372217.5	KIF2C Ensembl NCBI GeneCards UniProt Show fit	kinesin family member 2C
chr7_+_80134794 Show fit	12.02	ENST00000649796.2	GNAI1 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha i1
chr22_+_18110679 Show fit	11.81	ENST00000316027.10	TUBA8 Ensembl NCBI GeneCards UniProt Show fit	tubulin alpha 8
chr17_-_75848641 Show fit	11.73	ENST00000586257.5	WBP2 Ensembl NCBI GeneCards UniProt Show fit	WW domain binding protein 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	83.6	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.6	48.6	GO:0070125	mitochondrial translational elongation(GO:0070125)
1.7	32.5	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.7	28.3	GO:0000920	cell separation after cytokinesis(GO:0000920)
1.2	28.0	GO:0071294	cellular response to zinc ion(GO:0071294)
0.1	27.5	GO:0043687	post-translational protein modification(GO:0043687)
1.8	23.9	GO:1904321	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
1.4	22.3	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
1.3	22.2	GO:0003322	pancreatic A cell development(GO:0003322)
1.2	22.1	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)

Showing 1 to 10 of 487 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	140.1	GO:0043209	myelin sheath(GO:0043209)
1.0	57.7	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	41.8	GO:0005874	microtubule(GO:0005874)
0.6	35.8	GO:0043034	costamere(GO:0043034)
0.9	28.6	GO:0035371	microtubule plus-end(GO:0035371)
0.7	28.2	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	27.5	GO:0005730	nucleolus(GO:0005730)
1.5	26.7	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
1.9	24.5	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3	24.2	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)

Showing 1 to 10 of 216 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	87.9	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3	38.6	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2	36.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.3	32.5	GO:0003774	motor activity(GO:0003774)
0.1	31.0	GO:0005525	GTP binding(GO:0005525)
0.9	27.4	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.3	26.6	GO:0051087	chaperone binding(GO:0051087)
1.6	25.0	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.1	22.3	GO:0003735	structural constituent of ribosome(GO:0003735)
2.7	21.3	GO:0019237	centromeric DNA binding(GO:0019237)

Showing 1 to 10 of 355 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	54.1	PID AURORA B PATHWAY	Aurora B signaling
0.6	46.5	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.4	43.3	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.5	35.0	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.3	34.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.2	33.3	PID ARF 3PATHWAY	Arf1 pathway
0.1	23.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	22.5	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
1.6	22.4	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	19.5	PID CDC42 PATHWAY	CDC42 signaling events

Showing 1 to 10 of 75 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	137.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.9	52.4	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
2.0	41.5	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
1.5	41.3	REACTOME KINESINS	Genes involved in Kinesins
0.5	38.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.6	34.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	29.9	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.8	27.9	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.8	27.7	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.5	24.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases

Showing 1 to 10 of 116 entries

Results for RARG

Z-value: 1.19

Motif logo

Transcription factors associated with RARG

Activity-expression correlation:

Activity profile of RARG motif

Sorted Z-values of RARG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RARG

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: