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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RBPJ
Z-value: 0.73
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Transcription factors associated with RBPJ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RBPJ | hg38_v1_chr4_+_26320563_26320665, hg38_v1_chr4_+_26321365_26321410 | -0.09 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RBPJ
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_79767843 Show fit | 11.77 |
ENST00000337919.9
|
hes related family bHLH transcription factor with YRPW motif 1 |
|
| chr17_-_58529277 Show fit | 11.41 |
ENST00000579371.5
|
septin 4 |
|
| chr17_-_58529344 Show fit | 11.38 |
ENST00000317268.7
|
septin 4 |
|
| chr17_-_58529303 Show fit | 11.13 |
ENST00000580844.5
|
septin 4 |
|
| chr8_-_79767462 Show fit | 10.46 |
ENST00000674295.1
ENST00000518733.1 ENST00000674418.1 ENST00000674358.1 ENST00000354724.8 |
hes related family bHLH transcription factor with YRPW motif 1 |
|
| chr4_-_175812746 Show fit | 9.02 |
ENST00000393658.6
|
glycoprotein M6A |
|
| chr4_+_155667654 Show fit | 8.86 |
ENST00000513574.1
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr9_-_137028878 Show fit | 8.42 |
ENST00000625103.1
ENST00000614293.4 |
ATP binding cassette subfamily A member 2 |
|
| chr12_+_12785652 Show fit | 8.02 |
ENST00000356591.5
|
apolipoprotein L domain containing 1 |
|
| chr12_-_16606795 Show fit | 7.63 |
ENST00000447609.5
|
LIM domain only 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.2 | 24.6 | GO:0036304 | umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027) |
| 0.1 | 12.7 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.2 | 11.1 | GO:0003407 | neural retina development(GO:0003407) |
| 1.2 | 11.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 3.2 | 9.6 | GO:1900195 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 0.1 | 9.0 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 1.4 | 8.4 | GO:0032383 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 1.6 | 8.0 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.9 | 8.0 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.5 | 7.9 | GO:0003322 | pancreatic A cell development(GO:0003322) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 12.9 | GO:0043235 | receptor complex(GO:0043235) |
| 0.1 | 12.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.1 | 9.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.8 | 7.8 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 6.7 | GO:0005770 | late endosome(GO:0005770) |
| 1.3 | 6.6 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.1 | 6.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 6.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.2 | 5.7 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 25.2 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 12.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 1.8 | 11.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 10.4 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.1 | 9.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 3.2 | 9.6 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.1 | 7.9 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 7.7 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.8 | 7.0 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.5 | 6.9 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 12.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 12.1 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.3 | 9.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 7.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 6.9 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 6.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 4.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 11.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 9.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.4 | 8.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.2 | 7.9 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.3 | 6.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.4 | 6.8 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.2 | 5.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 4.3 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 3.8 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |