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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RCOR1_MTA3
Z-value: 2.85
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RCOR1 | hg38_v1_chr14_+_102592611_102592668 | 0.39 | 2.0e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.8 | 1742.4 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 20.9 | 1590.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 14.2 | 924.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 3.0 | 895.7 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 9.7 | 632.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 8.0 | 615.4 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 13.3 | 585.4 | GO:0036260 | 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260) |
| 24.2 | 532.9 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 8.0 | 483.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 14.5 | 462.9 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 4787.9 | GO:0070062 | extracellular exosome(GO:0070062) |
| 4.3 | 1953.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 4.4 | 1476.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 9.4 | 1292.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 20.1 | 784.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 5.4 | 783.7 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 13.1 | 770.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 14.4 | 717.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 24.3 | 681.1 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 4.4 | 635.6 | GO:0005681 | spliceosomal complex(GO:0005681) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 3031.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.1 | 2210.9 | GO:0003723 | RNA binding(GO:0003723) |
| 8.7 | 1799.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 15.6 | 826.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 17.5 | 822.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 5.4 | 782.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 9.5 | 713.6 | GO:0019003 | GDP binding(GO:0019003) |
| 21.5 | 602.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 4.0 | 538.5 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 8.9 | 517.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.9 | 1917.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 13.8 | 841.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 12.1 | 665.3 | PID ATR PATHWAY | ATR signaling pathway |
| 12.7 | 595.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 6.9 | 569.8 | PID E2F PATHWAY | E2F transcription factor network |
| 12.1 | 494.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 8.1 | 486.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 6.7 | 469.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 9.8 | 462.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 9.4 | 383.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 22.0 | 1606.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 15.2 | 1215.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 16.6 | 944.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 26.7 | 880.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 26.3 | 840.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 7.1 | 839.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 5.3 | 754.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 20.2 | 747.5 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 10.4 | 697.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 13.0 | 687.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |