ISMARA results: REL

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for REL

Z-value: 1.21

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Transcription factors associated with REL

Gene Symbol	Gene ID	Gene Info
REL Ensembl NCBI GeneCards UniProt	ENSG00000162924.15	REL

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
REL	hg38_v1_chr2_+_60881515_60881552, hg38_v1_chr2_+_60881553_60881619	0.29	1.5e-05	Click!

Activity profile of REL motif

Sorted Z-values of REL motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

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Promoter	Score	Transcript	Gene	Gene Info
chr6_+_137867241 Show fit	43.50	ENST00000612899.5 ENST00000420009.5	TNFAIP3 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 3
chr6_+_137867414 Show fit	42.53	ENST00000237289.8 ENST00000433680.1	TNFAIP3 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 3
chrX_-_154371210 Show fit	25.03	ENST00000369856.8 ENST00000422373.6 ENST00000360319.9	FLNA Ensembl NCBI GeneCards UniProt Show fit	filamin A
chr1_-_159924529 Show fit	24.43	ENST00000320307.8	TAGLN2 Ensembl NCBI GeneCards UniProt Show fit	transgelin 2
chr17_-_4949037 Show fit	24.00	ENST00000572383.1	PFN1 Ensembl NCBI GeneCards UniProt Show fit	profilin 1
chr12_+_51238854 Show fit	22.57	ENST00000549732.6 ENST00000604900.5	DAZAP2 Ensembl NCBI GeneCards UniProt Show fit	DAZ associated protein 2
chr11_-_58578096 Show fit	22.49	ENST00000528954.5 ENST00000528489.1	LPXN Ensembl NCBI GeneCards UniProt Show fit	leupaxin
chr10_+_17229267 Show fit	22.26	ENST00000224237.9	VIM Ensembl NCBI GeneCards UniProt Show fit	vimentin
chr5_-_151087131 Show fit	21.11	ENST00000315050.11 ENST00000523338.5 ENST00000522100.5	TNIP1 Ensembl NCBI GeneCards UniProt Show fit	TNFAIP3 interacting protein 1
chr1_-_159925496 Show fit	20.75	ENST00000368097.9	TAGLN2 Ensembl NCBI GeneCards UniProt Show fit	transgelin 2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
28.7	86.0	GO:0034147	regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.3	54.1	GO:0002377	immunoglobulin production(GO:0002377)
0.2	46.3	GO:0002576	platelet degranulation(GO:0002576)
2.7	35.6	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
3.8	30.4	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
2.5	30.1	GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.8	28.8	GO:0060334	regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.2	28.0	GO:0006958	complement activation, classical pathway(GO:0006958)
0.6	27.6	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
2.3	25.1	GO:1903003	positive regulation of protein deubiquitination(GO:1903003)

Showing 1 to 10 of 135 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	73.2	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3	56.5	GO:0072562	blood microparticle(GO:0072562)
0.8	41.5	GO:0002102	podosome(GO:0002102)
0.3	35.6	GO:0005882	intermediate filament(GO:0005882)
0.0	33.8	GO:0005654	nucleoplasm(GO:0005654)
0.3	30.6	GO:0000118	histone deacetylase complex(GO:0000118)
5.0	25.0	GO:0031523	Myb complex(GO:0031523)
0.1	22.4	GO:0016607	nuclear speck(GO:0016607)
0.2	21.1	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.8	19.8	GO:0005916	fascia adherens(GO:0005916)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.6	92.9	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.4	85.7	GO:0003823	antigen binding(GO:0003823)
0.1	50.1	GO:0045296	cadherin binding(GO:0045296)
0.9	42.4	GO:0050699	WW domain binding(GO:0050699)
7.1	35.6	GO:1990254	keratin filament binding(GO:1990254)
0.7	32.4	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.6	30.1	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	28.8	GO:0003723	RNA binding(GO:0003723)
5.0	25.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
1.8	24.0	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)

Showing 1 to 10 of 110 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	128.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.8	49.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.1	42.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.6	38.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.6	35.6	PID AURORA B PATHWAY	Aurora B signaling
2.1	23.4	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.3	23.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	19.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	16.9	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.9	16.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions

Showing 1 to 10 of 35 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	116.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
1.9	42.6	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
1.2	35.6	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.9	32.4	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4	27.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	24.0	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.6	19.8	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	18.8	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.1	18.3	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.4	12.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis

Showing 1 to 10 of 53 entries

Results for REL

Z-value: 1.21

Motif logo

Transcription factors associated with REL

Activity-expression correlation:

Activity profile of REL motif

Sorted Z-values of REL motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: