ISMARA results: RELB

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RELB

Z-value: 0.79

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Transcription factors associated with RELB

Gene Symbol	Gene ID	Gene Info
RELB Ensembl NCBI GeneCards UniProt	ENSG00000104856.14	RELB

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RELB	hg38_v1_chr19_+_45001430_45001525	0.38	7.3e-09	Click!

Activity profile of RELB motif

Sorted Z-values of RELB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RELB

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr6_+_32741382 Show fit	11.96	ENST00000374940.4	HLA-DQA2 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DQ alpha 2
chr5_-_150412743 Show fit	10.94	ENST00000353334.11 ENST00000009530.12 ENST00000377795.7	CD74 Ensembl NCBI GeneCards UniProt Show fit	CD74 molecule
chr2_+_90159840 Show fit	9.35	ENST00000377032.5	IGKV1D-12 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1D-12
chr6_+_32637419 Show fit	8.89	ENST00000374949.2	HLA-DQA1 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DQ alpha 1
chr2_-_89100352 Show fit	8.72	ENST00000479981.1	IGKV1-16 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-16
chr7_+_94394886 Show fit	8.22	ENST00000297268.11 ENST00000620463.1	COL1A2 Ensembl NCBI GeneCards UniProt Show fit	collagen type I alpha 2 chain
chr2_-_89320146 Show fit	7.74	ENST00000498574.1	IGKV1-39 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-39
chr10_+_17229267 Show fit	7.31	ENST00000224237.9	VIM Ensembl NCBI GeneCards UniProt Show fit	vimentin
chr4_-_74099187 Show fit	6.96	ENST00000508487.3	CXCL2 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 2
chr6_+_29723421 Show fit	6.93	ENST00000259951.12 ENST00000434407.6	HLA-F Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class I, F

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	40.5	GO:2000257	regulation of protein activation cascade(GO:2000257)
0.3	32.2	GO:0031295	T cell costimulation(GO:0031295)
2.0	20.0	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
4.2	12.6	GO:0070429	regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.1	11.4	GO:0005977	glycogen metabolic process(GO:0005977)
3.6	10.9	GO:0035691	macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.3	10.9	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
2.3	9.2	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.7	8.6	GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.5	8.6	GO:0032688	negative regulation of interferon-beta production(GO:0032688)

Showing 1 to 10 of 181 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	42.9	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	26.0	GO:0005615	extracellular space(GO:0005615)
0.1	25.6	GO:0072562	blood microparticle(GO:0072562)
1.8	20.0	GO:0042611	MHC protein complex(GO:0042611)
1.5	19.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	15.8	GO:0005884	actin filament(GO:0005884)
0.5	10.0	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.0	9.0	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	9.0	GO:0000323	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.6	8.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	44.5	GO:0003823	antigen binding(GO:0003823)
2.3	32.0	GO:0032395	MHC class II receptor activity(GO:0032395)
0.2	16.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
1.0	14.8	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
2.3	13.6	GO:0046979	TAP2 binding(GO:0046979)
0.9	12.6	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
1.5	11.7	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
2.2	10.9	GO:0042289	MHC class II protein binding(GO:0042289)
0.2	10.1	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.7	9.9	GO:0005078	MAP-kinase scaffold activity(GO:0005078)

Showing 1 to 10 of 133 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	32.5	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.3	13.4	NABA COLLAGENS	Genes encoding collagen proteins
0.1	11.0	PID NOTCH PATHWAY	Notch signaling pathway
0.5	9.7	ST STAT3 PATHWAY	STAT3 Pathway
0.2	9.2	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	9.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	8.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	7.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	7.3	PID AURORA B PATHWAY	Aurora B signaling
0.0	6.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	27.2	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4	20.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
1.8	20.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	16.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	11.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	9.3	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.1	9.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.5	8.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.5	8.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.2	7.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins

Showing 1 to 10 of 66 entries

Results for RELB

Z-value: 0.79

Motif logo

Transcription factors associated with RELB

Activity-expression correlation:

Activity profile of RELB motif

Sorted Z-values of RELB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RELB

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: