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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for REST

Z-value: 2.44

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.19 REST

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg38_v1_chr4_+_56908094_56908134-0.414.1e-10Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_66755 85.37 ENST00000538872.6
IQSEC3
IQ motif and Sec7 domain ArfGEF 3
chr4_+_157220654 79.85 ENST00000393815.6
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr4_+_157220691 78.63 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr20_+_46029165 78.59 ENST00000616201.4
ENST00000616202.4
ENST00000616933.4
ENST00000626937.2
SLC12A5
solute carrier family 12 member 5
chr20_+_46029206 77.05 ENST00000243964.7
SLC12A5
solute carrier family 12 member 5
chrX_-_47619850 70.01 ENST00000295987.13
ENST00000340666.5
SYN1
synapsin I
chr14_+_92923143 69.71 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr20_+_5911501 62.28 ENST00000378961.9
ENST00000455042.1
CHGB
chromogranin B
chr12_+_112791933 60.54 ENST00000551052.5
ENST00000415485.7
RPH3A
rabphilin 3A
chr1_+_32886456 60.17 ENST00000373467.4
HPCA
hippocalcin
chr17_+_44308573 58.15 ENST00000590941.5
ENST00000225441.11
ENST00000426726.8
RUNDC3A
RUN domain containing 3A
chr12_+_112791738 58.08 ENST00000389385.9
RPH3A
rabphilin 3A
chr15_-_82709859 56.61 ENST00000542200.2
ENST00000535359.6
ENST00000668990.2
ENST00000652847.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chr14_-_51095091 56.49 ENST00000684578.1
TRIM9
tripartite motif containing 9
chr15_-_82709886 56.04 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
AP3B2
adaptor related protein complex 3 subunit beta 2
chr15_-_82709775 51.49 ENST00000535348.5
AP3B2
adaptor related protein complex 3 subunit beta 2
chr15_-_82709823 47.39 ENST00000666973.1
ENST00000664460.1
ENST00000669930.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chrX_-_49200174 47.35 ENST00000472598.5
ENST00000263233.9
ENST00000479808.5
SYP
synaptophysin
chr1_-_241357171 46.69 ENST00000440928.6
RGS7
regulator of G protein signaling 7
chr1_-_241357085 46.28 ENST00000366564.5
RGS7
regulator of G protein signaling 7
chr17_+_32486975 45.06 ENST00000313401.4
CDK5R1
cyclin dependent kinase 5 regulatory subunit 1
chr8_-_56445941 40.56 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chr11_+_125903320 40.37 ENST00000525943.1
DDX25
DEAD-box helicase 25
chr10_+_26216665 38.45 ENST00000259271.7
GAD2
glutamate decarboxylase 2
chr1_+_65309517 38.24 ENST00000371069.5
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr10_-_101031095 37.58 ENST00000645349.1
ENST00000619208.6
ENST00000644782.1
ENST00000370215.7
ENST00000646029.1
PDZD7
PDZ domain containing 7
chr2_-_51032390 36.40 ENST00000404971.5
NRXN1
neurexin 1
chr11_-_66347560 34.92 ENST00000311181.5
B4GAT1
beta-1,4-glucuronyltransferase 1
chr2_-_51032536 31.53 ENST00000626899.1
ENST00000406316.6
NRXN1
neurexin 1
chr2_-_51032091 30.36 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
NRXN1
neurexin 1
chr10_-_49762276 30.17 ENST00000374103.9
OGDHL
oxoglutarate dehydrogenase L
chr16_+_4958289 29.59 ENST00000251170.12
SEC14L5
SEC14 like lipid binding 5
chr16_+_24256313 29.46 ENST00000005284.4
CACNG3
calcium voltage-gated channel auxiliary subunit gamma 3
chr10_-_49762335 29.46 ENST00000419399.4
ENST00000432695.2
OGDHL
oxoglutarate dehydrogenase L
chr3_-_48662877 27.23 ENST00000164024.5
CELSR3
cadherin EGF LAG seven-pass G-type receptor 3
chr1_-_175743529 26.90 ENST00000367674.7
ENST00000263525.6
TNR
tenascin R
chr19_-_55180104 26.52 ENST00000537500.5
SYT5
synaptotagmin 5
chrX_+_7147675 26.24 ENST00000674429.1
STS
steroid sulfatase
chr9_+_137139481 25.85 ENST00000371546.8
ENST00000371550.8
ENST00000371553.7
ENST00000371555.8
ENST00000371559.8
ENST00000371560.4
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr4_+_8580387 25.32 ENST00000382487.5
GPR78
G protein-coupled receptor 78
chr8_-_90082871 23.28 ENST00000265431.7
CALB1
calbindin 1
chr19_-_55180242 22.58 ENST00000592470.1
ENST00000354308.8
SYT5
synaptotagmin 5
chr9_-_136205122 22.42 ENST00000371748.10
LHX3
LIM homeobox 3
chr2_+_46297397 22.25 ENST00000263734.5
EPAS1
endothelial PAS domain protein 1
chr11_+_45885625 22.23 ENST00000241014.6
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr9_+_137139139 21.66 ENST00000371561.8
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr16_+_2969307 20.63 ENST00000576565.1
ENST00000318782.9
PAQR4
progestin and adipoQ receptor family member 4
chrX_-_153971810 20.53 ENST00000310441.12
HCFC1
host cell factor C1
chr16_+_2969270 20.51 ENST00000293978.12
PAQR4
progestin and adipoQ receptor family member 4
chr1_-_151716782 20.28 ENST00000420342.1
ENST00000290583.9
CELF3
CUGBP Elav-like family member 3
chr1_+_154567820 20.03 ENST00000637900.1
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr3_+_62318983 20.00 ENST00000232519.9
ENST00000462069.6
ENST00000465142.5
C3orf14
chromosome 3 open reading frame 14
chr3_+_62319037 19.86 ENST00000494481.5
C3orf14
chromosome 3 open reading frame 14
chr10_+_26216766 19.80 ENST00000376261.8
GAD2
glutamate decarboxylase 2
chr1_+_154567770 19.24 ENST00000368476.4
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr2_-_47570905 19.22 ENST00000327876.5
KCNK12
potassium two pore domain channel subfamily K member 12
chrX_-_153875847 17.53 ENST00000361699.8
ENST00000361981.7
L1CAM
L1 cell adhesion molecule
chr21_-_32728030 17.18 ENST00000382499.7
ENST00000433931.7
ENST00000382491.7
SYNJ1
synaptojanin 1
chr19_-_3971051 16.03 ENST00000545797.7
ENST00000596311.5
DAPK3
death associated protein kinase 3
chrX_+_153972729 15.72 ENST00000369982.5
TMEM187
transmembrane protein 187
chrX_+_7147237 14.26 ENST00000666110.2
STS
steroid sulfatase
chr6_+_154039480 14.16 ENST00000229768.9
ENST00000419506.6
ENST00000524163.5
ENST00000414028.6
ENST00000435918.6
ENST00000337049.8
OPRM1
opioid receptor mu 1
chr9_-_121050264 12.40 ENST00000223642.3
C5
complement C5
chr5_+_71719267 12.09 ENST00000296777.5
CARTPT
CART prepropeptide
chr7_+_155070317 10.60 ENST00000287907.3
HTR5A
5-hydroxytryptamine receptor 5A
chr6_+_154039416 10.58 ENST00000452687.6
OPRM1
opioid receptor mu 1
chr19_+_840991 10.44 ENST00000234347.10
PRTN3
proteinase 3
chr14_-_94293024 10.20 ENST00000393096.5
SERPINA10
serpin family A member 10
chr14_-_94293071 9.69 ENST00000554723.5
SERPINA10
serpin family A member 10
chr10_+_101031223 9.34 ENST00000393459.5
ENST00000224807.9
SFXN3
sideroflexin 3
chr4_+_95091462 9.23 ENST00000264568.8
BMPR1B
bone morphogenetic protein receptor type 1B
chr9_-_128275935 9.15 ENST00000610329.4
GOLGA2
golgin A2
chr11_-_6655788 8.94 ENST00000299441.5
DCHS1
dachsous cadherin-related 1
chr19_-_11529116 8.90 ENST00000592312.5
ENST00000590480.1
ENST00000585318.5
ENST00000270517.12
ENST00000252440.11
ENST00000417981.6
ECSIT
ECSIT signaling integrator
chr16_+_285680 8.86 ENST00000435833.1
PDIA2
protein disulfide isomerase family A member 2
chr15_-_26773737 8.46 ENST00000299267.8
GABRB3
gamma-aminobutyric acid type A receptor subunit beta3
chr17_-_3433841 8.34 ENST00000248384.1
OR1E2
olfactory receptor family 1 subfamily E member 2
chr10_-_44385043 8.13 ENST00000374426.6
ENST00000395794.2
ENST00000374429.6
ENST00000395793.7
ENST00000343575.10
ENST00000395795.5
CXCL12
C-X-C motif chemokine ligand 12
chr6_+_25652201 7.88 ENST00000612225.4
ENST00000377961.3
SCGN
secretagogin, EF-hand calcium binding protein
chr20_-_62220267 7.32 ENST00000317393.10
ENST00000611492.1
ENST00000340177.10
HRH3
histamine receptor H3
chr9_-_128275987 7.17 ENST00000490628.2
ENST00000421699.7
ENST00000611957.4
ENST00000450617.6
GOLGA2
golgin A2
chr3_+_120908072 7.06 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
STXBP5L
syntaxin binding protein 5 like
chr4_-_174829212 6.81 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr6_+_154039333 6.24 ENST00000428397.6
OPRM1
opioid receptor mu 1
chr11_-_125903190 6.19 ENST00000227474.8
ENST00000613398.4
ENST00000534158.5
ENST00000529801.1
PUS3
pseudouridine synthase 3
chr12_-_57050102 6.17 ENST00000300119.8
MYO1A
myosin IA
chr7_-_101165558 6.03 ENST00000611537.1
ENST00000249330.3
VGF
VGF nerve growth factor inducible
chr5_-_151924846 5.94 ENST00000274576.9
GLRA1
glycine receptor alpha 1
chr5_-_151924824 5.91 ENST00000455880.2
GLRA1
glycine receptor alpha 1
chr12_+_52301833 5.76 ENST00000293525.5
KRT86
keratin 86
chr12_+_71439789 5.51 ENST00000266674.10
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr12_+_71439976 5.19 ENST00000536515.5
ENST00000540815.2
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr17_-_3398410 4.91 ENST00000322608.2
OR1E1
olfactory receptor family 1 subfamily E member 1
chr11_+_62613236 4.33 ENST00000278833.4
ROM1
retinal outer segment membrane protein 1
chr14_-_94293260 4.17 ENST00000261994.9
SERPINA10
serpin family A member 10
chr2_+_225399684 3.69 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr19_-_11529094 3.46 ENST00000588998.5
ENST00000586149.1
ECSIT
ECSIT signaling integrator
chr1_+_171781635 3.34 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr6_+_152750789 2.69 ENST00000367244.8
ENST00000367243.7
VIP
vasoactive intestinal peptide
chr9_+_114329869 2.62 ENST00000431067.4
ORM2
orosomucoid 2
chr12_-_12684490 2.39 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr6_+_109978256 2.24 ENST00000414000.3
GPR6
G protein-coupled receptor 6
chr11_+_92969651 1.53 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr10_-_77638369 0.64 ENST00000372443.6
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr11_+_637244 0.40 ENST00000176183.6
DRD4
dopamine receptor D4
chr1_+_212432891 0.10 ENST00000366988.5
NENF
neudesin neurotrophic factor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
25.9 155.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
23.2 69.7 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
18.8 56.5 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
18.5 92.6 GO:0021586 pons maturation(GO:0021586)
10.6 211.5 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
10.1 40.6 GO:0051866 general adaptation syndrome(GO:0051866)
9.7 58.3 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
8.9 98.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
8.6 60.2 GO:1902075 cellular response to salt(GO:1902075)
7.9 39.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
7.7 30.6 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
7.0 34.9 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
6.8 20.5 GO:0019046 release from viral latency(GO:0019046)
6.8 27.2 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
6.7 26.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
6.0 12.1 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
4.6 55.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
4.2 58.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
4.0 24.1 GO:0008218 bioluminescence(GO:0008218)
3.9 47.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
3.9 158.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
3.8 165.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
3.8 37.6 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
3.7 22.4 GO:0021523 somatic motor neuron differentiation(GO:0021523)
3.7 70.0 GO:0097091 synaptic vesicle clustering(GO:0097091)
3.1 12.4 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
3.0 85.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
2.9 23.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
2.3 16.3 GO:0090166 Golgi disassembly(GO:0090166)
2.2 8.9 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
2.1 10.7 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
2.1 10.6 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
2.0 8.1 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
2.0 22.2 GO:0043129 norepinephrine metabolic process(GO:0042415) surfactant homeostasis(GO:0043129)
1.7 10.4 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
1.7 11.9 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
1.6 19.2 GO:0030322 stabilization of membrane potential(GO:0030322)
1.5 22.2 GO:0007258 JUN phosphorylation(GO:0007258)
1.5 59.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
1.3 29.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.3 9.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
1.2 6.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
1.2 7.3 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
1.1 40.5 GO:0006706 steroid catabolic process(GO:0006706)
1.0 8.9 GO:0006621 protein retention in ER lumen(GO:0006621)
0.9 16.0 GO:0031033 myosin filament organization(GO:0031033)
0.8 20.3 GO:0030575 nuclear body organization(GO:0030575) positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.7 40.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.5 8.9 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.3 2.7 GO:0070459 prolactin secretion(GO:0070459)
0.3 2.6 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.3 93.0 GO:0006457 protein folding(GO:0006457)
0.2 17.5 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 4.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.2 6.2 GO:0030033 microvillus assembly(GO:0030033)
0.2 7.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 12.4 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 64.6 GO:0043687 post-translational protein modification(GO:0043687)
0.1 9.3 GO:0055072 iron ion homeostasis(GO:0055072)
0.1 9.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.9 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.1 6.8 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 0.6 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 5.8 GO:0070268 cornification(GO:0070268)
0.0 3.0 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 1.5 GO:0007631 feeding behavior(GO:0007631)
0.0 0.1 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 3.7 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
52.8 158.5 GO:0098843 postsynaptic endocytic zone(GO:0098843)
15.1 211.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
12.0 155.5 GO:0060077 inhibitory synapse(GO:0060077)
9.4 37.6 GO:0002139 stereocilia coupling link(GO:0002139)
9.0 45.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
8.5 59.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
7.9 47.2 GO:1990769 proximal neuron projection(GO:1990769)
7.5 60.2 GO:0044327 dendritic spine head(GO:0044327)
5.8 40.6 GO:0032280 symmetric synapse(GO:0032280)
5.4 26.9 GO:0072534 perineuronal net(GO:0072534)
4.5 40.4 GO:0033391 chromatoid body(GO:0033391)
4.4 69.7 GO:0042583 chromaffin granule(GO:0042583)
3.6 47.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
3.4 47.5 GO:0098839 NMDA selective glutamate receptor complex(GO:0017146) synaptic cleft(GO:0043083) postsynaptic density membrane(GO:0098839)
2.7 155.6 GO:0043198 dendritic shaft(GO:0043198)
2.5 22.2 GO:0044294 dendritic growth cone(GO:0044294)
2.1 29.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.8 16.3 GO:0000137 Golgi cis cisterna(GO:0000137)
1.8 118.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.6 70.0 GO:0000795 synaptonemal complex(GO:0000795)
1.6 12.4 GO:0005579 membrane attack complex(GO:0005579)
1.5 20.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.4 39.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.3 93.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.0 17.5 GO:0044295 axonal growth cone(GO:0044295)
1.0 30.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.9 34.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.9 98.3 GO:0042734 presynaptic membrane(GO:0042734)
0.7 9.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.6 56.5 GO:0008021 synaptic vesicle(GO:0008021)
0.6 17.2 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.4 138.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 4.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 8.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 23.3 GO:0043197 dendritic spine(GO:0043197)
0.2 16.5 GO:0043204 perikaryon(GO:0043204)
0.2 38.0 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 22.2 GO:0005884 actin filament(GO:0005884)
0.1 5.8 GO:0045095 keratin filament(GO:0045095)
0.1 10.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 20.3 GO:0030133 transport vesicle(GO:0030133)
0.0 22.2 GO:0016607 nuclear speck(GO:0016607)
0.0 2.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 10.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 119.8 GO:0016021 integral component of membrane(GO:0016021)
0.0 12.4 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
19.8 158.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
15.0 45.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
11.9 59.6 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
11.1 155.6 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
10.8 118.6 GO:0042301 phosphate ion binding(GO:0042301)
10.1 40.5 GO:0004773 steryl-sulfatase activity(GO:0004773)
9.5 123.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
8.3 58.1 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
7.9 47.5 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
7.3 58.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
7.0 34.9 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
5.8 40.6 GO:0001515 opioid peptide activity(GO:0001515)
4.1 98.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
3.7 18.7 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
3.3 23.3 GO:0005499 vitamin D binding(GO:0005499)
3.3 16.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
2.6 20.5 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
2.5 85.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.5 17.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
2.3 20.3 GO:0097322 7SK snRNA binding(GO:0097322)
1.9 19.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.6 22.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
1.4 39.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
1.1 16.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.9 8.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.9 47.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.9 10.6 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.8 7.3 GO:0004969 histamine receptor activity(GO:0004969)
0.8 47.3 GO:0015485 cholesterol binding(GO:0015485)
0.8 9.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.7 8.9 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.6 78.6 GO:0005179 hormone activity(GO:0005179)
0.5 29.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 40.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.5 8.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.5 6.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.5 1.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 12.4 GO:0008009 chemokine activity(GO:0008009)
0.4 47.5 GO:0000149 SNARE binding(GO:0000149)
0.4 22.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 38.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 298.7 GO:0005215 transporter activity(GO:0005215)
0.2 20.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 22.4 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 9.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 12.4 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 40.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 59.9 GO:0019900 kinase binding(GO:0019900)
0.1 37.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 6.2 GO:0003774 motor activity(GO:0003774)
0.0 20.0 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 158.5 PID NCADHERIN PATHWAY N-cadherin signaling events
1.3 67.3 PID REELIN PATHWAY Reelin signaling pathway
0.4 22.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 30.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 40.6 PID AP1 PATHWAY AP-1 transcription factor network
0.3 17.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.3 16.9 PID EPHB FWD PATHWAY EPHB forward signaling
0.3 16.3 PID PLK1 PATHWAY PLK1 signaling events
0.2 8.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 9.2 PID BMP PATHWAY BMP receptor signaling
0.1 26.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 8.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 24.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 9.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.9 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 206.0 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
3.1 40.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
3.0 70.0 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.6 58.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
1.9 39.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.6 45.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
1.1 155.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.1 16.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
1.0 38.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.8 10.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.7 30.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.7 29.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.6 136.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.6 22.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.6 17.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.6 27.1 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.4 47.2 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.4 17.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 9.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 56.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 2.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 12.4 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1 9.3 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway