ISMARA results: REST

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for REST

Z-value: 2.44

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Transcription factors associated with REST

Gene Symbol	Gene ID	Gene Info
REST Ensembl NCBI GeneCards UniProt	ENSG00000084093.19	REST

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
REST	hg38_v1_chr4_+_56908094_56908134	-0.41	4.1e-10	Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Promoter	Score	Transcript	Gene	Gene Info
chr12_+_66755 Show fit	85.37	ENST00000538872.6	IQSEC3 Ensembl NCBI GeneCards UniProt Show fit	IQ motif and Sec7 domain ArfGEF 3
chr4_+_157220654 Show fit	79.85	ENST00000393815.6	GRIA2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr4_+_157220691 Show fit	78.63	ENST00000509417.5 ENST00000645636.1 ENST00000296526.12 ENST00000264426.14	GRIA2 Ensembl NCBI GeneCards UniProt Show fit	glutamate ionotropic receptor AMPA type subunit 2
chr20_+_46029165 Show fit	78.59	ENST00000616201.4 ENST00000616202.4 ENST00000616933.4 ENST00000626937.2	SLC12A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 5
chr20_+_46029206 Show fit	77.05	ENST00000243964.7	SLC12A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 5
chrX_-_47619850 Show fit	70.01	ENST00000295987.13 ENST00000340666.5	SYN1 Ensembl NCBI GeneCards UniProt Show fit	synapsin I
chr14_+_92923143 Show fit	69.71	ENST00000216492.10 ENST00000334654.4	CHGA Ensembl NCBI GeneCards UniProt Show fit	chromogranin A
chr20_+_5911501 Show fit	62.28	ENST00000378961.9 ENST00000455042.1	CHGB Ensembl NCBI GeneCards UniProt Show fit	chromogranin B
chr12_+_112791933 Show fit	60.54	ENST00000551052.5 ENST00000415485.7	RPH3A Ensembl NCBI GeneCards UniProt Show fit	rabphilin 3A
chr1_+_32886456 Show fit	60.17	ENST00000373467.4	HPCA Ensembl NCBI GeneCards UniProt Show fit	hippocalcin

Showing 1 to 10 of 106 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.6	211.5	GO:0099514	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
3.8	165.8	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
3.9	158.5	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
25.9	155.6	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
8.9	98.3	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3	93.0	GO:0006457	protein folding(GO:0006457)
18.5	92.6	GO:0021586	pons maturation(GO:0021586)
3.0	85.4	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
3.7	70.0	GO:0097091	synaptic vesicle clustering(GO:0097091)
23.2	69.7	GO:1901899	positive regulation of relaxation of cardiac muscle(GO:1901899)

Showing 1 to 10 of 68 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.1	211.5	GO:0030123	AP-3 adaptor complex(GO:0030123)
52.8	158.5	GO:0098843	postsynaptic endocytic zone(GO:0098843)
2.7	155.6	GO:0043198	dendritic shaft(GO:0043198)
12.0	155.5	GO:0060077	inhibitory synapse(GO:0060077)
0.4	138.1	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	119.8	GO:0016021	integral component of membrane(GO:0016021)
1.8	118.6	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.9	98.3	GO:0042734	presynaptic membrane(GO:0042734)
1.3	93.0	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
1.6	70.0	GO:0000795	synaptonemal complex(GO:0000795)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	298.7	GO:0005215	transporter activity(GO:0005215)
19.8	158.5	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
11.1	155.6	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
9.5	123.6	GO:0031681	G-protein beta-subunit binding(GO:0031681)
10.8	118.6	GO:0042301	phosphate ion binding(GO:0042301)
4.1	98.3	GO:0033130	acetylcholine receptor binding(GO:0033130)
2.5	85.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6	78.6	GO:0005179	hormone activity(GO:0005179)
0.1	59.9	GO:0019900	kinase binding(GO:0019900)
11.9	59.6	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	158.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.3	67.3	PID REELIN PATHWAY	Reelin signaling pathway
0.3	40.6	PID AP1 PATHWAY	AP-1 transcription factor network
0.3	30.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	26.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	24.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	22.2	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.3	17.5	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	16.9	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	16.3	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.4	206.0	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.1	155.6	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.6	136.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
3.0	70.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
2.6	58.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.2	56.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4	47.2	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
1.6	45.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
3.1	40.5	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
1.9	39.3	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors

Showing 1 to 10 of 23 entries

Results for REST

Z-value: 2.44

Motif logo

Transcription factors associated with REST

Activity-expression correlation:

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: