Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for RFX3_RFX2
Z-value: 4.51
Motif logo
Transcription factors associated with RFX3_RFX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX2 | hg38_v1_chr19_-_6110463_6110541 | 0.56 | 4.1e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX3_RFX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 250.5 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 1.0 | 211.3 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 30.4 | 182.5 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 9.1 | 172.7 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 11.5 | 172.6 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 17.0 | 169.8 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 2.2 | 167.6 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 3.8 | 165.9 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 6.4 | 153.1 | GO:0002021 | response to dietary excess(GO:0002021) |
| 8.0 | 152.2 | GO:0034389 | lipid particle organization(GO:0034389) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 225.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.6 | 217.2 | GO:0005874 | microtubule(GO:0005874) |
| 4.1 | 213.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.3 | 212.8 | GO:0043005 | neuron projection(GO:0043005) |
| 1.7 | 199.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 10.1 | 182.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.3 | 175.1 | GO:0031430 | M band(GO:0031430) |
| 2.2 | 158.5 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.6 | 145.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.7 | 136.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 309.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 3.5 | 228.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.6 | 177.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 9.7 | 174.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 13.3 | 172.6 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 1.2 | 163.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 1.4 | 147.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.3 | 139.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 138.0 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.7 | 137.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 250.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 3.6 | 217.1 | ST ADRENERGIC | Adrenergic Pathway |
| 1.6 | 117.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 4.1 | 70.0 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 1.4 | 68.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.0 | 60.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.7 | 44.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 36.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 31.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.4 | 24.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 263.9 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 6.0 | 172.6 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.3 | 128.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 2.7 | 106.8 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.6 | 102.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.7 | 89.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 2.2 | 68.9 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 2.1 | 61.1 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.1 | 60.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.4 | 58.4 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |