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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RFX5
Z-value: 1.49
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Transcription factors associated with RFX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX5 | hg38_v1_chr1_-_151347234_151347326 | 0.51 | 8.8e-16 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_32589833 Show fit | 86.52 |
ENST00000360004.5
|
major histocompatibility complex, class II, DR beta 1 |
|
| chr6_+_33075952 Show fit | 80.18 |
ENST00000418931.7
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr5_-_150412743 Show fit | 76.68 |
ENST00000353334.11
ENST00000009530.12 ENST00000377795.7 |
CD74 molecule |
|
| chr6_-_32530268 Show fit | 75.21 |
ENST00000374975.4
|
major histocompatibility complex, class II, DR beta 5 |
|
| chr6_-_32953017 Show fit | 69.74 |
ENST00000395305.7
ENST00000374843.9 ENST00000395303.7 ENST00000429234.1 |
major histocompatibility complex, class II, DM alpha novel protein |
|
| chr6_+_32854179 Show fit | 47.10 |
ENST00000374859.3
|
proteasome 20S subunit beta 9 |
|
| chr6_+_30489501 Show fit | 46.41 |
ENST00000376630.5
|
major histocompatibility complex, class I, E |
|
| chr6_-_32666648 Show fit | 40.14 |
ENST00000399082.7
ENST00000399079.7 ENST00000374943.8 ENST00000434651.6 |
major histocompatibility complex, class II, DQ beta 1 |
|
| chr6_-_32844643 Show fit | 38.98 |
ENST00000374881.3
|
proteasome 20S subunit beta 8 |
|
| chr6_+_32844789 Show fit | 38.15 |
ENST00000414474.5
|
proteasome 20S subunit beta 9 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 253.1 | GO:0031295 | T cell costimulation(GO:0031295) |
| 47.0 | 188.2 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 1.2 | 117.9 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 25.6 | 76.7 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 2.1 | 64.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 20.2 | 60.7 | GO:0002428 | antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) |
| 27.0 | 54.1 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 3.7 | 29.5 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 1.9 | 25.3 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.0 | 22.4 | GO:0006629 | lipid metabolic process(GO:0006629) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 28.0 | 532.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 17.7 | 124.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 107.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 8.4 | 92.6 | GO:0042611 | MHC protein complex(GO:0042611) |
| 10.8 | 54.1 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 26.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.4 | 14.0 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.4 | 11.0 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 10.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 4.9 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.6 | 412.0 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 4.4 | 124.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 4.4 | 110.2 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 11.0 | 76.7 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 14.4 | 71.9 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 3.6 | 18.1 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.3 | 14.0 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 1.2 | 11.0 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 2.5 | 10.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 6.2 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 86.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 54.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 14.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 8.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 4.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 4.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.4 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.5 | 241.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.8 | 197.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.7 | 117.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 2.5 | 54.1 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 4.0 | 43.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.3 | 18.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 14.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 5.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.3 | 5.0 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |