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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RFX7_RFX4_RFX1
Z-value: 2.90
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX1 | hg38_v1_chr19_-_14006262_14006330 | 0.42 | 9.6e-11 | Click! |
| RFX7 | hg38_v1_chr15_-_56243829_56243891, hg38_v1_chr15_-_56245074_56245088 | 0.31 | 2.2e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_16197900 Show fit | 263.39 |
ENST00000429941.6
ENST00000291439.8 ENST00000444449.6 ENST00000589822.5 |
adaptor related protein complex 1 subunit mu 1 |
|
| chr19_-_49813259 Show fit | 120.46 |
ENST00000313777.9
|
fuzzy planar cell polarity protein |
|
| chr19_-_49813223 Show fit | 109.93 |
ENST00000533418.5
|
fuzzy planar cell polarity protein |
|
| chr11_+_72080313 Show fit | 103.21 |
ENST00000307198.11
ENST00000538413.6 ENST00000642648.1 ENST00000289488.7 |
leucine rich transmembrane and O-methyltransferase domain containing leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr11_+_72080803 Show fit | 98.05 |
ENST00000423494.6
ENST00000539587.6 ENST00000536917.2 ENST00000538478.5 ENST00000324866.11 ENST00000643715.1 ENST00000439209.5 |
leucine rich transmembrane and O-methyltransferase domain containing leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr19_-_49813151 Show fit | 94.91 |
ENST00000528094.5
ENST00000526575.1 |
fuzzy planar cell polarity protein |
|
| chr11_+_72080595 Show fit | 93.22 |
ENST00000647530.1
ENST00000539271.6 ENST00000642510.1 |
leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr3_-_128994111 Show fit | 81.90 |
ENST00000645291.2
ENST00000265068.9 |
cilia and flagella associated protein 92 (putative) |
|
| chr17_-_15341577 Show fit | 71.22 |
ENST00000543896.1
ENST00000395930.6 ENST00000539245.5 ENST00000539316.1 |
tektin 3 |
|
| chr8_+_10672646 Show fit | 67.22 |
ENST00000521818.1
|
chromosome 8 open reading frame 74 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 81.3 | 325.3 | GO:0060825 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 15.5 | 294.5 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 13.2 | 263.4 | GO:0043485 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 7.9 | 165.5 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 6.8 | 121.7 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 19.0 | 114.2 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 14.0 | 83.9 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 1.6 | 71.3 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 17.8 | 71.2 | GO:0080154 | regulation of fertilization(GO:0080154) |
| 5.9 | 71.0 | GO:0003351 | epithelial cilium movement(GO:0003351) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 302.1 | GO:0042995 | cell projection(GO:0042995) |
| 5.5 | 279.8 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 2.9 | 214.7 | GO:0036126 | sperm flagellum(GO:0036126) |
| 8.7 | 164.4 | GO:0036038 | MKS complex(GO:0036038) |
| 12.5 | 150.0 | GO:0005858 | axonemal dynein complex(GO:0005858) |
| 0.2 | 119.3 | GO:0010008 | endosome membrane(GO:0010008) |
| 1.4 | 110.3 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 100.3 | GO:0005615 | extracellular space(GO:0005615) |
| 1.9 | 95.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.3 | 87.6 | GO:0045202 | synapse(GO:0045202) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.7 | 294.5 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 2.1 | 178.6 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 6.6 | 132.3 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.4 | 128.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 5.3 | 121.7 | GO:0031005 | filamin binding(GO:0031005) |
| 9.8 | 88.0 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 14.0 | 83.9 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 7.5 | 52.7 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 1.1 | 47.6 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 3.3 | 45.7 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 244.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 1.4 | 90.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.7 | 54.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.7 | 48.3 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 1.1 | 42.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 1.4 | 36.6 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.4 | 33.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.5 | 32.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 26.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.6 | 24.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.8 | 263.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 1.6 | 125.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 58.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 2.2 | 58.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 51.4 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.9 | 51.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 2.2 | 48.0 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 1.9 | 40.3 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 2.6 | 33.5 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.8 | 31.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |