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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RHOXF1
Z-value: 1.31
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Transcription factors associated with RHOXF1
Network of associatons between targets according to the STRING database.
First level regulatory network of RHOXF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_5227063 Show fit | 30.53 |
ENST00000335295.4
ENST00000485743.1 ENST00000647020.1 |
hemoglobin subunit beta |
|
| chr12_-_91153149 Show fit | 28.03 |
ENST00000550758.1
|
decorin |
|
| chr4_+_186191549 Show fit | 25.16 |
ENST00000378802.5
|
cytochrome P450 family 4 subfamily V member 2 |
|
| chr2_-_55269038 Show fit | 24.96 |
ENST00000417363.5
ENST00000412530.1 ENST00000366137.6 ENST00000420637.5 |
mitochondrial translational initiation factor 2 |
|
| chr18_+_24113341 Show fit | 23.69 |
ENST00000540918.2
|
tetratricopeptide repeat domain 39C |
|
| chr12_-_91146195 Show fit | 22.41 |
ENST00000548218.1
|
decorin |
|
| chr12_-_9115907 Show fit | 19.84 |
ENST00000318602.12
|
alpha-2-macroglobulin |
|
| chr16_+_176659 Show fit | 18.68 |
ENST00000320868.9
ENST00000397797.1 |
hemoglobin subunit alpha 1 |
|
| chr17_-_57850010 Show fit | 18.58 |
ENST00000313608.13
ENST00000578444.1 ENST00000579380.1 |
mitochondrial ribosomal protein S23 |
|
| chr10_+_46579084 Show fit | 18.03 |
ENST00000512997.5
ENST00000374321.9 ENST00000503753.5 |
synaptotagmin 15 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 63.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.6 | 44.3 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.4 | 43.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 9.8 | 39.1 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.9 | 38.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 10.8 | 32.4 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 6.3 | 31.6 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 10.2 | 30.5 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 3.7 | 26.2 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.9 | 25.8 | GO:0050912 | detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 204.2 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.1 | 136.8 | GO:0005615 | extracellular space(GO:0005615) |
| 3.9 | 50.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 12.3 | 49.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 2.7 | 47.9 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 42.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 2.5 | 39.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.4 | 39.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 33.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.2 | 30.4 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 58.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 5.1 | 46.3 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.4 | 43.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 42.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 40.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 5.0 | 34.8 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.3 | 30.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.4 | 29.9 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.9 | 29.4 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.9 | 29.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 129.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.2 | 84.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 50.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 35.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 15.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 14.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 13.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 12.4 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.2 | 12.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.5 | 10.8 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 65.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 51.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 43.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 1.5 | 37.1 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.4 | 28.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.5 | 27.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.5 | 22.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.9 | 22.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 21.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 19.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |