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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RORA
Z-value: 0.94
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Transcription factors associated with RORA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RORA | hg38_v1_chr15_-_61229297_61229306, hg38_v1_chr15_-_60592507_60592545 | -0.11 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RORA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 67.8 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 6.4 | 57.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 12.1 | 48.6 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 1.8 | 36.9 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 2.6 | 28.9 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.8 | 24.7 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 1.5 | 22.8 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 6.5 | 19.6 | GO:0002368 | B cell cytokine production(GO:0002368) |
| 0.3 | 18.8 | GO:0043486 | histone exchange(GO:0043486) |
| 1.3 | 18.7 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 66.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 9.6 | 57.7 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.1 | 42.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 36.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.6 | 33.6 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 5.9 | 29.4 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.2 | 28.5 | GO:0000922 | spindle pole(GO:0000922) |
| 1.9 | 25.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 3.3 | 22.8 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 20.1 | GO:0000785 | chromatin(GO:0000785) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 58.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 4.0 | 48.6 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 2.3 | 36.9 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.7 | 33.6 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.4 | 29.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 6.2 | 24.7 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
| 0.2 | 24.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 23.8 | GO:0008270 | zinc ion binding(GO:0008270) |
| 1.6 | 22.8 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 3.3 | 19.6 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 48.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 1.1 | 36.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 2.1 | 28.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.6 | 19.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.3 | 19.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 13.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 13.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 12.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 11.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 8.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 98.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.0 | 82.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.7 | 54.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.0 | 28.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 19.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 17.6 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.6 | 14.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 12.7 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 11.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 10.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |