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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RORC
Z-value: 0.31
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Transcription factors associated with RORC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RORC | hg38_v1_chr1_-_151826085_151826108, hg38_v1_chr1_-_151831768_151831833 | 0.07 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RORC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.2 | 3.9 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 1.2 | 3.6 | GO:1903572 | regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.0 | 2.6 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.5 | 2.4 | GO:0019087 | transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295) |
| 0.0 | 1.7 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.3 | 1.6 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.1 | 1.5 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
| 0.5 | 1.4 | GO:0014740 | negative regulation of muscle hyperplasia(GO:0014740) |
| 0.3 | 1.0 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 2.4 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 1.5 | GO:0033177 | proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 1.4 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.3 | 1.0 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.0 | 0.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 0.6 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 0.0 | 0.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.6 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 4.0 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.7 | 3.6 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.9 | 2.6 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 2.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.5 | 2.4 | GO:0033906 | hyaluronoglucuronidase activity(GO:0033906) |
| 0.4 | 1.7 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.1 | 1.6 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.3 | 1.5 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.3 | 1.4 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 3.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.6 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 3.9 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 3.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 2.6 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.1 | 2.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 1.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 1.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.6 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.6 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |