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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RREB1
Z-value: 0.86
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Transcription factors associated with RREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RREB1 | hg38_v1_chr6_+_7107597_7107821 | 0.40 | 7.4e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RREB1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_72080313 Show fit | 12.16 |
ENST00000307198.11
ENST00000538413.6 ENST00000642648.1 ENST00000289488.7 |
leucine rich transmembrane and O-methyltransferase domain containing leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr19_-_6720641 Show fit | 10.58 |
ENST00000245907.11
|
complement C3 |
|
| chrX_-_152733715 Show fit | 9.66 |
ENST00000452779.3
ENST00000370287.7 |
chondrosarcoma associated gene 1 |
|
| chrX_-_152733689 Show fit | 8.46 |
ENST00000370291.6
|
chondrosarcoma associated gene 1 |
|
| chr11_+_72080595 Show fit | 7.91 |
ENST00000647530.1
ENST00000539271.6 ENST00000642510.1 |
leucine rich transmembrane and O-methyltransferase domain containing |
|
| chr1_-_204411804 Show fit | 7.85 |
ENST00000367188.5
|
protein phosphatase 1 regulatory subunit 15B |
|
| chr16_+_397226 Show fit | 7.05 |
ENST00000433358.5
|
NME/NM23 nucleoside diphosphate kinase 4 |
|
| chr16_+_397209 Show fit | 6.25 |
ENST00000382940.8
|
NME/NM23 nucleoside diphosphate kinase 4 |
|
| chr10_-_47763592 Show fit | 6.16 |
ENST00000615923.4
ENST00000623662.4 |
novel protein identical to synaptotagmin XV |
|
| chr16_-_4538469 Show fit | 5.69 |
ENST00000588381.1
ENST00000563332.6 |
cell death inducing p53 target 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 20.1 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.9 | 17.5 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 1.7 | 15.5 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 3.5 | 10.6 | GO:0002445 | type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) |
| 0.1 | 10.1 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 2.2 | 8.6 | GO:2000910 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
| 0.3 | 8.4 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.4 | 7.5 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.4 | 5.9 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.3 | 5.9 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 18.9 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.2 | 17.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.7 | 13.9 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 11.1 | GO:0031252 | cell leading edge(GO:0031252) |
| 1.4 | 10.1 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.2 | 9.8 | GO:0008305 | integrin complex(GO:0008305) |
| 0.5 | 8.6 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.5 | 7.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 7.7 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 2.2 | 20.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 1.1 | 17.5 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.1 | 16.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 10.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 10.9 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 1.7 | 8.6 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.2 | 7.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 7.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 6.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 9.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 9.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.0 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 5.6 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.1 | 5.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 5.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.9 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 4.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 17.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.7 | 14.2 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.4 | 8.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 8.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 6.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 6.5 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.2 | 5.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 5.3 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 5.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.9 | 5.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |