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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RUNX1_RUNX2
Z-value: 2.12
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Transcription factors associated with RUNX1_RUNX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX1 | hg38_v1_chr21_-_34887148_34887222 | 0.47 | 2.7e-13 | Click! |
| RUNX2 | hg38_v1_chr6_+_45422564_45422598 | 0.42 | 1.2e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX1_RUNX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 177.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.2 | 99.9 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.2 | 70.1 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 3.1 | 56.1 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.4 | 54.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.3 | 53.9 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 6.7 | 53.6 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.6 | 53.4 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 2.2 | 51.7 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) |
| 16.7 | 50.0 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 229.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 202.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.6 | 92.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 78.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 77.1 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.6 | 71.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.7 | 64.5 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 2.9 | 55.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 54.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.4 | 54.2 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 301.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 123.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 5.1 | 76.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.5 | 62.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 1.7 | 53.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 49.0 | GO:0004872 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
| 2.4 | 47.8 | GO:0005522 | profilin binding(GO:0005522) |
| 11.9 | 47.7 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 1.5 | 46.4 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.6 | 45.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 70.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.4 | 67.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 62.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.6 | 61.0 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.9 | 58.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 1.0 | 50.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.3 | 49.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.7 | 46.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.7 | 39.5 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.6 | 33.4 | PID BCR 5PATHWAY | BCR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 110.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 3.5 | 84.9 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 3.7 | 71.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.0 | 67.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.7 | 66.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 2.2 | 56.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 2.0 | 55.1 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.3 | 51.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.0 | 47.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 1.4 | 35.9 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |