ISMARA results: RUNX3

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RUNX3_BCL11A

Z-value: 1.41

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Transcription factors associated with RUNX3_BCL11A

Gene Symbol	Gene ID	Gene Info
RUNX3 Ensembl NCBI GeneCards UniProt	ENSG00000020633.19	RUNX3
BCL11A Ensembl NCBI GeneCards UniProt	ENSG00000119866.22	BCL11A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RUNX3	hg38_v1_chr1_-_24964984_24965020	0.71	3.2e-35	Click!
BCL11A	hg38_v1_chr2_-_60553618_60553664	0.14	3.3e-02	Click!

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

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Promoter	Score	Transcript	Gene	Gene Info
chr1_-_24964984 Show fit	64.55	ENST00000338888.3 ENST00000399916.5	RUNX3 Ensembl NCBI GeneCards UniProt Show fit	RUNX family transcription factor 3
chr2_-_157444044 Show fit	39.20	ENST00000264192.8	CYTIP Ensembl NCBI GeneCards UniProt Show fit	cytohesin 1 interacting protein
chr11_-_58578096 Show fit	38.20	ENST00000528954.5 ENST00000528489.1	LPXN Ensembl NCBI GeneCards UniProt Show fit	leupaxin
chr4_-_83114715 Show fit	31.11	ENST00000426923.2 ENST00000311507.9 ENST00000509973.5	PLAC8 Ensembl NCBI GeneCards UniProt Show fit	placenta associated 8
chrX_-_107717054 Show fit	28.65	ENST00000503515.1 ENST00000372397.6	TSC22D3 Ensembl NCBI GeneCards UniProt Show fit	TSC22 domain family member 3
chr5_+_55102635 Show fit	27.56	ENST00000274306.7	GZMA Ensembl NCBI GeneCards UniProt Show fit	granzyme A
chr5_+_35856883 Show fit	27.36	ENST00000506850.5 ENST00000303115.8 ENST00000511982.1	IL7R Ensembl NCBI GeneCards UniProt Show fit	interleukin 7 receptor
chrX_-_136780925 Show fit	27.11	ENST00000250617.7	ARHGEF6 Ensembl NCBI GeneCards UniProt Show fit	Rac/Cdc42 guanine nucleotide exchange factor 6
chr5_+_157180816 Show fit	25.21	ENST00000422843.8	ITK Ensembl NCBI GeneCards UniProt Show fit	IL2 inducible T cell kinase
chr1_+_209756032 Show fit	22.10	ENST00000400959.7 ENST00000367025.8	TRAF3IP3 Ensembl NCBI GeneCards UniProt Show fit	TRAF3 interacting protein 3

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	54.0	GO:0050680	negative regulation of epithelial cell proliferation(GO:0050680)
2.4	53.3	GO:0097320	membrane tubulation(GO:0097320)
0.3	39.1	GO:0038096	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
4.8	38.2	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
2.0	36.5	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
2.4	31.4	GO:1900625	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3	30.3	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.4	29.4	GO:0006968	cellular defense response(GO:0006968)
3.6	28.6	GO:0070235	regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
2.5	27.6	GO:0032074	negative regulation of nuclease activity(GO:0032074)

Showing 1 to 10 of 172 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	92.4	GO:0001891	phagocytic cup(GO:0001891)
1.3	86.6	GO:0001772	immunological synapse(GO:0001772)
0.4	56.2	GO:0005884	actin filament(GO:0005884)
0.2	54.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	47.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.8	38.2	GO:0002102	podosome(GO:0002102)
0.1	35.4	GO:0005938	cell cortex(GO:0005938)
2.9	31.4	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2	31.1	GO:0035578	azurophil granule lumen(GO:0035578)
0.6	27.8	GO:0008305	integrin complex(GO:0008305)

Showing 1 to 10 of 83 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	61.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2	50.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	37.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	32.4	GO:0004896	cytokine receptor activity(GO:0004896)
0.8	31.4	GO:0005540	hyaluronic acid binding(GO:0005540)
3.2	28.6	GO:0043426	MRF binding(GO:0043426)
1.3	27.0	GO:0005522	profilin binding(GO:0005522)
1.4	26.5	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	26.4	GO:0005543	phospholipid binding(GO:0005543)
0.2	25.9	GO:0017124	SH3 domain binding(GO:0017124)

Showing 1 to 10 of 131 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	103.6	PID IL12 2PATHWAY	IL12-mediated signaling events
0.9	82.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.4	38.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	33.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	29.8	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.5	27.4	PID ARF6 PATHWAY	Arf6 signaling events
0.4	24.8	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.3	23.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.7	20.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4	14.9	PID BCR 5PATHWAY	BCR signaling pathway

Showing 1 to 10 of 45 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	75.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.7	60.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7	43.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	38.7	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
1.4	32.9	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.8	27.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
1.3	26.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
1.0	25.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.5	24.7	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
5.5	21.9	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains

Showing 1 to 10 of 63 entries

Results for RUNX3_BCL11A

Z-value: 1.41

Motif logo

Transcription factors associated with RUNX3_BCL11A

Activity-expression correlation:

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: