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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RXRG
Z-value: 1.18
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Transcription factors associated with RXRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RXRG | hg38_v1_chr1_-_165445220_165445355, hg38_v1_chr1_-_165445088_165445140 | 0.15 | 3.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RXRG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 34.3 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 4.8 | 28.5 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.3 | 28.5 | GO:0006073 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
| 0.5 | 28.1 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 3.6 | 25.1 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 1.1 | 23.8 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 7.8 | 23.3 | GO:1900226 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 5.6 | 22.5 | GO:0035627 | ceramide transport(GO:0035627) |
| 1.0 | 22.3 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.8 | 15.9 | GO:0048240 | sperm capacitation(GO:0048240) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 29.7 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 26.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 2.6 | 23.3 | GO:0072687 | meiotic spindle(GO:0072687) |
| 1.8 | 19.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 1.9 | 18.8 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.2 | 18.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.9 | 17.9 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.3 | 17.5 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.8 | 17.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 16.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 33.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.3 | 32.1 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.9 | 28.9 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 3.5 | 28.0 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 3.6 | 25.1 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.6 | 23.9 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 5.9 | 23.7 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 7.8 | 23.3 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.1 | 23.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 5.6 | 22.5 | GO:0097001 | ceramide binding(GO:0097001) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 31.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.5 | 29.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.7 | 27.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 23.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 14.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 12.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 12.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.3 | 11.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 11.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 11.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 36.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.8 | 27.0 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 23.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.5 | 17.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 17.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.3 | 16.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 16.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 16.0 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.3 | 15.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 15.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |