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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SCRT1_SCRT2
Z-value: 1.35
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Transcription factors associated with SCRT1_SCRT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SCRT1 | hg38_v1_chr8_-_144336451_144336503 | -0.22 | 1.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SCRT1_SCRT2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 79.0 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 11.8 | 59.2 | GO:0007412 | axon target recognition(GO:0007412) |
| 6.3 | 50.6 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.6 | 47.6 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 9.2 | 46.1 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 7.3 | 29.2 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.1 | 26.7 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 3.0 | 20.7 | GO:0033591 | response to L-ascorbic acid(GO:0033591) |
| 1.3 | 20.2 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 2.7 | 19.2 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 79.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 2.4 | 75.3 | GO:0005921 | gap junction(GO:0005921) |
| 1.2 | 68.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.2 | 63.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.5 | 37.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 1.4 | 29.5 | GO:0043219 | lateral loop(GO:0043219) |
| 0.8 | 20.7 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 20.5 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 1.6 | 19.2 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.3 | 18.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 102.5 | GO:0003779 | actin binding(GO:0003779) |
| 9.9 | 59.2 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 12.7 | 50.6 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.7 | 48.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 46.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 32.8 | GO:0042802 | identical protein binding(GO:0042802) |
| 4.9 | 29.2 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.9 | 20.5 | GO:0031005 | filamin binding(GO:0031005) |
| 1.1 | 20.2 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.2 | 19.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 90.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 1.1 | 62.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.7 | 29.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 27.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 25.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 22.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 17.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 8.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 7.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 6.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 46.1 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 1.6 | 29.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.6 | 20.2 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 1.4 | 19.2 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.6 | 18.9 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.6 | 18.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 16.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.5 | 14.9 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.4 | 11.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.3 | 10.2 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |