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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SHOX

Z-value: 0.60

Motif logo

Transcription factors associated with SHOX

Gene Symbol Gene ID Gene Info
ENSG00000185960.14 SHOX
ENSG00000185960.14 SHOX

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr11_-_117877463 21.64 ENST00000527717.5
FXYD domain containing ion transport regulator 6
chr11_-_117876719 21.35 ENST00000529335.6
ENST00000260282.8
FXYD domain containing ion transport regulator 6
chr11_-_117876892 21.16 ENST00000539526.5
FXYD domain containing ion transport regulator 6
chr11_-_111923722 13.03 ENST00000527950.5
crystallin alpha B
chrX_-_13817027 10.77 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr12_-_16608073 10.02 ENST00000441439.6
LIM domain only 3
chr12_-_16608183 9.33 ENST00000354662.5
ENST00000538051.5
LIM domain only 3
chr4_-_56681588 8.08 ENST00000554144.5
ENST00000381260.7
HOP homeobox
chr4_-_56681288 8.01 ENST00000556376.6
ENST00000420433.6
HOP homeobox
chr4_+_112860981 7.11 ENST00000671704.1
ankyrin 2
chr4_+_112860912 7.02 ENST00000671951.1
ankyrin 2
chr4_+_112861053 6.71 ENST00000672221.1
ankyrin 2
chr3_+_111999326 6.14 ENST00000494932.1
transgelin 3
chr4_+_113292838 5.99 ENST00000672411.1
ENST00000673231.1
ankyrin 2
chr3_+_111999189 5.90 ENST00000455401.6
transgelin 3
chr13_-_35855627 5.86 ENST00000379893.5
doublecortin like kinase 1
chr12_-_16606795 5.85 ENST00000447609.5
LIM domain only 3
chr3_+_111998739 5.65 ENST00000393917.6
ENST00000273368.8
transgelin 3
chr4_+_113292925 5.64 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ankyrin 2
chr2_+_90038848 5.49 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr12_-_10130241 5.28 ENST00000353231.9
ENST00000525605.1
C-type lectin domain containing 7A
chr3_+_111998915 5.16 ENST00000478951.6
transgelin 3
chr13_-_35855758 4.51 ENST00000615680.4
doublecortin like kinase 1
chr2_-_223602284 4.51 ENST00000421386.1
ENST00000305409.3
ENST00000433889.1
secretogranin II
chr5_+_36606355 4.44 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
solute carrier family 1 member 3
chr12_-_10130143 4.31 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
C-type lectin domain containing 7A
chr10_+_110005804 4.13 ENST00000360162.7
adducin 3
chr18_-_24397784 3.97 ENST00000399441.4
ENST00000319481.8
oxysterol binding protein like 1A
chr1_+_180632001 3.82 ENST00000367590.9
ENST00000367589.3
xenotropic and polytropic retrovirus receptor 1
chr17_-_10026265 3.75 ENST00000437099.6
ENST00000396115.6
growth arrest specific 7
chr12_-_6124662 3.61 ENST00000261405.10
von Willebrand factor
chr8_-_101790934 3.49 ENST00000523645.5
ENST00000520346.1
ENST00000220931.11
ENST00000522448.5
ENST00000522951.5
ENST00000522252.5
ENST00000519098.5
neurocalcin delta
chr1_-_45491150 3.44 ENST00000372086.4
testis associated actin remodelling kinase 2
chr12_-_89352395 3.43 ENST00000308385.6
dual specificity phosphatase 6
chr6_-_32941018 3.42 ENST00000418107.3
major histocompatibility complex, class II, DM beta
chr12_+_26195313 3.40 ENST00000422622.3
sarcospan
chr1_+_65992389 3.37 ENST00000423207.6
phosphodiesterase 4B
chr12_-_89352487 3.31 ENST00000548755.1
ENST00000279488.8
dual specificity phosphatase 6
chr5_-_24644968 3.27 ENST00000264463.8
cadherin 10
chr11_-_129192291 3.27 ENST00000682385.1
Rho GTPase activating protein 32
chr6_-_169250825 3.21 ENST00000676869.1
ENST00000676760.1
thrombospondin 2
chr16_+_7303245 3.10 ENST00000674626.1
RNA binding fox-1 homolog 1
chr2_-_50347789 3.07 ENST00000628364.2
neurexin 1
chr16_-_29899532 3.02 ENST00000308713.9
ENST00000617533.5
seizure related 6 homolog like 2
chr8_-_33599935 2.95 ENST00000523956.1
ENST00000256261.9
dual specificity phosphatase 26
chr1_-_150765735 2.91 ENST00000679898.1
ENST00000448301.7
ENST00000680664.1
ENST00000679512.1
ENST00000368985.8
ENST00000679582.1
cathepsin S
chr2_+_68734861 2.83 ENST00000467265.5
Rho GTPase activating protein 25
chr1_-_150765785 2.82 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr14_-_100569780 2.73 ENST00000355173.7
brain enriched guanylate kinase associated
chr6_-_39725387 2.72 ENST00000287152.12
kinesin family member 6
chr3_+_115623502 2.69 ENST00000305124.11
ENST00000393780.3
growth associated protein 43
chr10_-_49762335 2.66 ENST00000419399.4
ENST00000432695.2
oxoglutarate dehydrogenase L
chr3_+_4680617 2.66 ENST00000648212.1
inositol 1,4,5-trisphosphate receptor type 1
chr1_+_153774210 2.65 ENST00000271857.6
solute carrier family 27 member 3
chr10_-_49762276 2.63 ENST00000374103.9
oxoglutarate dehydrogenase L
chr4_+_7043315 2.63 ENST00000310074.8
ENST00000512388.1
transcriptional adaptor 2B
chr1_+_183805105 2.60 ENST00000360851.4
ral guanine nucleotide dissociation stimulator like 1
chr14_+_99481395 2.60 ENST00000389879.9
ENST00000557441.5
ENST00000555049.5
ENST00000555842.1
cyclin K
chr1_-_68232539 2.58 ENST00000370976.7
ENST00000354777.6
Wnt ligand secretion mediator
chr7_+_154305105 2.56 ENST00000332007.7
dipeptidyl peptidase like 6
chr1_-_152414256 2.52 ENST00000271835.3
cornulin
chr2_+_87338511 2.52 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr7_-_137343752 2.46 ENST00000393083.2
pleiotrophin
chr1_-_68232514 2.46 ENST00000262348.9
ENST00000370973.2
ENST00000370971.1
Wnt ligand secretion mediator
chr8_+_106726012 2.43 ENST00000449762.6
ENST00000297447.10
oxidation resistance 1
chr11_-_129192198 2.40 ENST00000310343.13
Rho GTPase activating protein 32
chr8_+_104223320 2.39 ENST00000339750.3
regulating synaptic membrane exocytosis 2
chr11_-_117876612 2.39 ENST00000584230.1
ENST00000526014.6
ENST00000584394.5
ENST00000614497.5
ENST00000532984.1
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr2_-_74392025 2.37 ENST00000440727.1
ENST00000409240.5
dynactin subunit 1
chr6_+_121437378 2.34 ENST00000650427.1
ENST00000647564.1
gap junction protein alpha 1
chr18_+_34976928 2.33 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
microtubule associated protein RP/EB family member 2
chr13_+_48256214 2.32 ENST00000650237.1
integral membrane protein 2B
chr2_-_74391837 2.31 ENST00000417090.1
ENST00000409868.5
ENST00000680606.1
dynactin subunit 1
chr5_+_141484997 2.30 ENST00000617094.1
ENST00000306593.2
ENST00000610539.1
ENST00000618371.4
protocadherin gamma subfamily C, 4
chr14_-_72894091 2.28 ENST00000556509.6
double PHD fingers 3
chr5_+_67004618 2.23 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chrX_+_108045050 2.21 ENST00000458383.1
ENST00000217957.10
V-set and immunoglobulin domain containing 1
chr17_-_10549694 2.21 ENST00000622564.4
myosin heavy chain 2
chr19_+_49513353 2.20 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chr19_+_49513154 2.19 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
Fc fragment of IgG receptor and transporter
chr16_-_29899245 2.13 ENST00000537485.5
seizure related 6 homolog like 2
chr2_+_90234809 2.12 ENST00000443397.5
immunoglobulin kappa variable 3D-7
chr2_+_68734773 2.10 ENST00000409202.8
Rho GTPase activating protein 25
chr7_+_70596078 2.09 ENST00000644506.1
activator of transcription and developmental regulator AUTS2
chr19_+_54137740 2.09 ENST00000644245.1
ENST00000646002.1
ENST00000221232.11
ENST00000440571.6
ENST00000617930.2
CCR4-NOT transcription complex subunit 3
chr5_+_161850597 2.09 ENST00000634335.1
ENST00000635880.1
gamma-aminobutyric acid type A receptor subunit alpha1
chr2_-_144517663 2.06 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
zinc finger E-box binding homeobox 2
chr2_-_88979016 2.05 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chrX_+_108044967 2.04 ENST00000415430.7
V-set and immunoglobulin domain containing 1
chr9_+_79571956 2.04 ENST00000376552.8
TLE family member 4, transcriptional corepressor
chr3_+_159069252 2.01 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1 readthrough
chr1_-_92486916 1.98 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr5_-_20575850 1.93 ENST00000507958.5
cadherin 18
chr3_+_69936629 1.93 ENST00000394348.2
ENST00000531774.1
melanocyte inducing transcription factor
chr7_-_22193824 1.91 ENST00000401957.6
Rap guanine nucleotide exchange factor 5
chr1_+_50108856 1.91 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAV like RNA binding protein 4
chr19_-_53254841 1.89 ENST00000601828.5
ENST00000599012.5
ENST00000598513.6
ENST00000598806.5
zinc finger protein 677
chr8_+_104223344 1.81 ENST00000523362.5
regulating synaptic membrane exocytosis 2
chr10_-_20897288 1.81 ENST00000377122.9
nebulette
chr2_-_49974155 1.81 ENST00000635519.1
neurexin 1
chr9_+_5890872 1.81 ENST00000381477.8
ENST00000381476.5
ENST00000381471.1
melan-A
chr2_+_90172802 1.77 ENST00000390277.3
immunoglobulin kappa variable 3D-11
chr8_-_18683932 1.77 ENST00000615573.4
pleckstrin and Sec7 domain containing 3
chr2_-_50347710 1.72 ENST00000342183.9
ENST00000401710.5
neurexin 1
chr1_+_50103903 1.71 ENST00000371827.5
ELAV like RNA binding protein 4
chr8_-_17676484 1.67 ENST00000634613.1
ENST00000519066.5
microtubule associated scaffold protein 1
chr12_+_26195543 1.66 ENST00000242729.7
sarcospan
chr17_-_10549612 1.66 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
myosin heavy chain 2
chr2_+_102418642 1.64 ENST00000264260.6
interleukin 18 receptor accessory protein
chr7_-_22194709 1.61 ENST00000458533.5
Rap guanine nucleotide exchange factor 5
chr8_-_18684033 1.59 ENST00000614430.3
pleckstrin and Sec7 domain containing 3
chr2_-_49974182 1.57 ENST00000412315.5
ENST00000378262.7
neurexin 1
chr10_+_18340821 1.55 ENST00000612743.1
ENST00000612134.4
calcium voltage-gated channel auxiliary subunit beta 2
chr19_-_51019699 1.53 ENST00000358789.8
kallikrein related peptidase 10
chr7_+_97732046 1.53 ENST00000350485.8
ENST00000346867.4
ENST00000319273.10
tachykinin precursor 1
chr10_+_18340699 1.53 ENST00000377329.10
calcium voltage-gated channel auxiliary subunit beta 2
chr3_-_115071333 1.51 ENST00000462705.5
zinc finger and BTB domain containing 20
chr7_-_13986439 1.47 ENST00000443608.5
ENST00000438956.5
ETS variant transcription factor 1
chr7_+_116222804 1.47 ENST00000393481.6
testin LIM domain protein
chr17_-_10549652 1.45 ENST00000245503.10
myosin heavy chain 2
chr19_+_4007714 1.41 ENST00000262971.3
protein inhibitor of activated STAT 4
chr7_-_22193728 1.40 ENST00000620335.4
Rap guanine nucleotide exchange factor 5
chr4_-_8871817 1.37 ENST00000400677.5
H6 family homeobox 1
chr6_+_113857333 1.37 ENST00000612661.2
myristoylated alanine rich protein kinase C substrate
chr8_-_18684093 1.35 ENST00000428502.6
pleckstrin and Sec7 domain containing 3
chr2_+_209579598 1.35 ENST00000445941.5
ENST00000673860.1
microtubule associated protein 2
chr12_+_6904733 1.33 ENST00000007969.12
ENST00000622489.4
ENST00000443597.7
ENST00000323702.9
leucine rich repeat containing 23
chr4_+_71339014 1.32 ENST00000340595.4
solute carrier family 4 member 4
chr12_-_10453330 1.32 ENST00000347831.9
ENST00000359151.8
killer cell lectin like receptor C1
chr3_+_69936583 1.32 ENST00000314557.10
ENST00000394351.9
melanocyte inducing transcription factor
chr9_+_12693327 1.31 ENST00000388918.10
tyrosinase related protein 1
chr6_+_26402237 1.29 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
butyrophilin subfamily 3 member A1
chr14_+_64986846 1.29 ENST00000246166.3
farnesyltransferase, CAAX box, beta
chr6_+_72212887 1.29 ENST00000523963.5
regulating synaptic membrane exocytosis 1
chr3_-_12545499 1.26 ENST00000564146.4
MKRN2 opposite strand
chr9_+_470291 1.26 ENST00000382303.5
KN motif and ankyrin repeat domains 1
chr7_-_13989891 1.26 ENST00000405218.6
ETS variant transcription factor 1
chr9_+_128566741 1.24 ENST00000630866.1
spectrin alpha, non-erythrocytic 1
chr6_+_72212802 1.23 ENST00000401910.7
regulating synaptic membrane exocytosis 1
chr3_-_112641128 1.21 ENST00000206423.8
coiled-coil domain containing 80
chr2_-_207167220 1.20 ENST00000421199.5
ENST00000457962.5
Kruppel like factor 7
chr12_-_118359105 1.19 ENST00000541186.5
ENST00000539872.5
TAO kinase 3
chr11_+_107591077 1.19 ENST00000531234.5
ENST00000265840.12
ELMO domain containing 1
chr12_+_6904962 1.19 ENST00000415834.5
ENST00000436789.5
leucine rich repeat containing 23
chr11_+_94973640 1.19 ENST00000335080.6
ENST00000536741.1
lysine demethylase 4D
chr12_+_12785652 1.18 ENST00000356591.5
apolipoprotein L domain containing 1
chr19_-_51020154 1.17 ENST00000391805.5
ENST00000599077.1
kallikrein related peptidase 10
chr7_-_83649097 1.16 ENST00000643230.2
semaphorin 3E
chr11_-_108222594 1.14 ENST00000278612.9
nuclear protein, coactivator of histone transcription
chr18_+_58341038 1.14 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chr13_+_35476740 1.11 ENST00000537702.5
neurobeachin
chr20_+_2295994 1.11 ENST00000381458.6
transglutaminase 3
chr8_-_42501224 1.09 ENST00000520262.6
ENST00000517366.1
solute carrier family 20 member 2
chr6_+_31615984 1.09 ENST00000376049.4
allograft inflammatory factor 1
chr6_+_26402289 1.09 ENST00000414912.2
butyrophilin subfamily 3 member A1
chr13_-_94479671 1.09 ENST00000377028.10
ENST00000446125.1
dopachrome tautomerase
chr14_+_32329256 1.09 ENST00000280979.9
A-kinase anchoring protein 6
chr2_-_24328113 1.09 ENST00000622089.4
intersectin 2
chr12_-_9869345 1.08 ENST00000228438.3
C-type lectin domain family 2 member B
chr1_-_158426237 1.06 ENST00000641042.1
olfactory receptor family 10 subfamily K member 2
chr17_+_74431338 1.06 ENST00000342648.9
ENST00000652232.1
ENST00000481232.2
G protein-coupled receptor class C group 5 member C
chr4_+_70242583 1.06 ENST00000304954.3
casein kappa
chr12_+_80707625 1.03 ENST00000228641.4
myogenic factor 6
chr6_+_42746958 1.03 ENST00000614467.4
BRD4 interacting chromatin remodeling complex associated protein like
chr6_-_34146080 1.02 ENST00000538487.7
ENST00000374181.8
glutamate metabotropic receptor 4
chr8_+_116938180 1.01 ENST00000378279.4
alanine and arginine rich domain containing protein
chr5_+_126423363 0.99 ENST00000285689.8
GRAM domain containing 2B
chrX_-_140505058 0.97 ENST00000370536.5
SRY-box transcription factor 3
chr7_-_78771265 0.96 ENST00000630991.2
ENST00000629359.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr7_-_87713287 0.96 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ATP binding cassette subfamily B member 1
chr1_+_160190567 0.96 ENST00000368078.8
calsequestrin 1
chr12_-_52573816 0.95 ENST00000549343.5
ENST00000305620.3
keratin 74
chr7_-_4862015 0.94 ENST00000404991.2
poly(A) polymerase beta
chr6_-_100464912 0.94 ENST00000369208.8
SIM bHLH transcription factor 1
chr5_+_126423122 0.93 ENST00000515200.5
GRAM domain containing 2B
chr16_+_86566821 0.92 ENST00000649859.1
forkhead box C2
chr12_-_7503744 0.91 ENST00000396620.7
ENST00000432237.3
CD163 molecule
chr12_-_118359639 0.91 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr18_+_48539017 0.91 ENST00000256413.8
cap binding complex dependent translation initiation factor
chr19_-_51020019 0.88 ENST00000309958.7
kallikrein related peptidase 10
chr6_-_136466858 0.87 ENST00000544465.5
microtubule associated protein 7
chr5_+_126423176 0.87 ENST00000542322.5
ENST00000544396.5
GRAM domain containing 2B
chr17_-_10518536 0.86 ENST00000226207.6
myosin heavy chain 1
chrX_+_22032301 0.86 ENST00000379374.5
phosphate regulating endopeptidase homolog X-linked
chr2_-_181680490 0.83 ENST00000684145.1
ENST00000295108.4
ENST00000684079.1
ENST00000683430.1
ceramide kinase like
neuronal differentiation 1
chr10_-_1737516 0.82 ENST00000381312.6
adenosine deaminase RNA specific B2 (inactive)
chr7_+_49773632 0.81 ENST00000340652.5
von Willebrand factor C domain containing 2
chr11_-_102705737 0.81 ENST00000260229.5
matrix metallopeptidase 27
chr1_-_151790475 0.81 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
tudor and KH domain containing
chr4_+_68447453 0.79 ENST00000305363.9
transmembrane serine protease 11E
chr12_+_18261511 0.79 ENST00000538779.6
ENST00000433979.6
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr5_+_70025247 0.78 ENST00000380751.9
ENST00000380750.8
ENST00000503931.5
ENST00000506542.1
small EDRK-rich factor 1B
chr6_+_26365215 0.77 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr15_+_58138368 0.77 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr7_-_13986498 0.76 ENST00000420159.6
ENST00000399357.7
ENST00000403527.5
ETS variant transcription factor 1
chr12_-_91153149 0.75 ENST00000550758.1
decorin
chr4_-_145180496 0.72 ENST00000447906.8
OTU deubiquitinase 4
chr18_-_500692 0.72 ENST00000400256.5
collectin subfamily member 12
chr12_-_111685720 0.71 ENST00000327551.6
BRCA1 associated protein
chr3_-_114758940 0.70 ENST00000464560.5
zinc finger and BTB domain containing 20

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 25.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
3.2 32.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.9 5.7 GO:0034769 basement membrane disassembly(GO:0034769)
1.7 6.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
1.7 5.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
1.5 4.4 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
1.1 3.4 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.0 2.9 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.9 10.8 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.8 2.5 GO:1904397 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.8 13.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.7 8.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.7 64.4 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.7 2.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.7 15.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.7 2.0 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.7 2.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.6 4.7 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.6 2.3 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.5 4.2 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.5 1.5 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.5 3.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.4 10.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.4 4.4 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 2.4 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.4 5.3 GO:0001778 plasma membrane repair(GO:0001778)
0.3 2.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.3 4.5 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.3 1.0 GO:1904383 response to sodium phosphate(GO:1904383)
0.3 1.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 3.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 0.9 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.3 1.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.3 12.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 1.3 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.3 5.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 1.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 2.1 GO:0016198 axon choice point recognition(GO:0016198)
0.2 2.5 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.2 2.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.2 1.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.2 1.3 GO:0018343 protein farnesylation(GO:0018343)
0.2 2.3 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.2 1.4 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 0.8 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.2 1.0 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 0.6 GO:0002665 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.2 0.6 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm development(GO:0048389) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) pattern specification involved in mesonephros development(GO:0061227) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in kidney development(GO:0072098) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter urothelium development(GO:0072190) ureter epithelial cell differentiation(GO:0072192) ureter morphogenesis(GO:0072197) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.2 4.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 0.2 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 0.6 GO:0010159 specification of organ position(GO:0010159)
0.2 0.5 GO:0061011 hepatic duct development(GO:0061011) hepatoblast differentiation(GO:0061017)
0.2 2.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.2 0.8 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.4 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.6 GO:0021759 globus pallidus development(GO:0021759)
0.1 1.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.5 GO:0021764 amygdala development(GO:0021764)
0.1 3.9 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.4 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 1.2 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.0 GO:1903961 positive regulation of anion channel activity(GO:1901529) positive regulation of anion transmembrane transport(GO:1903961)
0.1 0.6 GO:0089712 L-aspartate transport(GO:0070778) L-aspartate transmembrane transport(GO:0089712)
0.1 0.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 1.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 4.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 0.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.1 2.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 0.3 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.1 0.6 GO:0050955 thermoception(GO:0050955)
0.1 0.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 2.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.1 GO:0034776 response to histamine(GO:0034776) cellular response to histamine(GO:0071420)
0.1 2.6 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.1 0.7 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 3.2 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 1.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 0.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.2 GO:0070662 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) mast cell proliferation(GO:0070662)
0.1 0.6 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.2 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.1 0.3 GO:0002384 hepatic immune response(GO:0002384)
0.1 1.0 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 1.6 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 0.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.1 9.5 GO:0002377 immunoglobulin production(GO:0002377)
0.1 2.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 0.4 GO:0042713 sperm ejaculation(GO:0042713) Sertoli cell proliferation(GO:0060011)
0.1 0.3 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 1.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.0 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 2.5 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 3.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 3.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.0 GO:0007530 sex determination(GO:0007530)
0.0 0.9 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 6.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.0 1.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:0033306 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.0 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.6 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.7 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 1.2 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.3 GO:0032196 transposition(GO:0032196)
0.0 1.1 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.4 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.6 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 1.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.6 GO:0033081 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0 0.8 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 2.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 1.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 8.3 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.9 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.3 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.2 GO:1901018 positive regulation of potassium ion transmembrane transporter activity(GO:1901018)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.9 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 0.3 GO:0007625 grooming behavior(GO:0007625)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.9 GO:0006953 acute-phase response(GO:0006953)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 1.2 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.6 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.2 GO:0040032 parathyroid hormone secretion(GO:0035898) post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.0 1.6 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 1.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 2.3 GO:0009408 response to heat(GO:0009408)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 1.2 GO:0048813 dendrite morphogenesis(GO:0048813)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.8 5.7 GO:0036021 endolysosome lumen(GO:0036021)
0.8 13.0 GO:0097512 cardiac myofibril(GO:0097512)
0.8 5.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.7 2.6 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.6 30.6 GO:0031430 M band(GO:0031430)
0.4 2.7 GO:0032584 growth cone membrane(GO:0032584)
0.3 4.7 GO:0005869 dynactin complex(GO:0005869)
0.3 1.3 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.3 0.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 4.1 GO:0043073 germ cell nucleus(GO:0043073)
0.2 2.7 GO:0005955 calcineurin complex(GO:0005955)
0.2 3.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 4.5 GO:0031045 dense core granule(GO:0031045)
0.2 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.8 GO:0071546 pi-body(GO:0071546)
0.2 1.0 GO:0014802 terminal cisterna(GO:0014802)
0.2 1.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.2 3.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 2.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 3.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 1.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.6 GO:0030914 STAGA complex(GO:0030914)
0.2 0.5 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 3.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 5.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.7 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 5.1 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 15.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 5.0 GO:0032590 dendrite membrane(GO:0032590)
0.1 0.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 3.1 GO:1990752 microtubule end(GO:1990752)
0.1 1.2 GO:0008091 spectrin(GO:0008091)
0.1 22.4 GO:0043209 myelin sheath(GO:0043209)
0.1 23.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.4 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.7 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.2 GO:0044307 dendritic branch(GO:0044307)
0.1 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 4.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.9 GO:0031672 A band(GO:0031672)
0.0 2.0 GO:0001533 cornified envelope(GO:0001533)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.3 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 73.5 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 4.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 4.0 GO:0045121 membrane raft(GO:0045121)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.1 GO:0043204 perikaryon(GO:0043204)
0.0 0.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0019770 IgG receptor activity(GO:0019770)
1.1 5.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
1.0 67.7 GO:0017080 sodium channel regulator activity(GO:0017080)
1.0 3.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.9 2.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.7 2.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.6 2.5 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.5 32.5 GO:0030507 spectrin binding(GO:0030507)
0.4 2.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 13.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 6.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 2.3 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.4 10.3 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.4 4.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 8.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.3 1.0 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.3 1.3 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.3 4.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 0.9 GO:1990254 keratin filament binding(GO:1990254)
0.3 2.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 1.3 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.3 3.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 0.8 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.3 0.8 GO:0015265 urea channel activity(GO:0015265)
0.2 7.3 GO:0001968 fibronectin binding(GO:0001968)
0.2 1.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 2.1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 1.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.2 1.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.2 1.3 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.2 0.6 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.2 1.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 2.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 5.4 GO:0000146 microfilament motor activity(GO:0000146)
0.1 5.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.6 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 3.6 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 4.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 3.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 5.1 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.4 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 2.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 3.4 GO:0023023 MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026)
0.1 4.0 GO:0015248 sterol transporter activity(GO:0015248)
0.1 4.7 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.8 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 21.5 GO:0051015 actin filament binding(GO:0051015)
0.1 3.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 2.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.1 3.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.3 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 5.8 GO:0070888 E-box binding(GO:0070888)
0.1 0.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 1.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.4 GO:0017002 activin-activated receptor activity(GO:0017002) BMP receptor activity(GO:0098821)
0.1 0.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0004803 transposase activity(GO:0004803)
0.1 0.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.8 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 9.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.1 GO:0019166 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 7.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.5 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 8.7 GO:0003823 antigen binding(GO:0003823)
0.0 2.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 11.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.6 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 2.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 3.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.0 GO:0008066 glutamate receptor activity(GO:0008066)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 4.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.9 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 2.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 8.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 11.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.4 PID IFNG PATHWAY IFN-gamma pathway
0.1 4.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.0 PID IL23 PATHWAY IL23-mediated signaling events
0.0 3.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 7.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 6.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 3.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 5.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 3.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 12.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 3.4 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 1.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 2.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 5.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 0.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.0 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.6 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.6 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 4.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA