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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SIN3A_CHD1
Z-value: 1.77
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Transcription factors associated with SIN3A_CHD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD1 | hg38_v1_chr5_-_98928992_98929020 | 0.50 | 2.9e-15 | Click! |
| SIN3A | hg38_v1_chr15_-_75451650_75451746 | -0.00 | 9.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIN3A_CHD1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_224433776 Show fit | 55.55 |
ENST00000678879.1
ENST00000651911.2 |
WD repeat domain 26 |
|
| chr10_+_28533307 Show fit | 34.13 |
ENST00000347934.8
|
WW domain containing adaptor with coiled-coil |
|
| chr10_+_28533108 Show fit | 30.77 |
ENST00000354911.9
|
WW domain containing adaptor with coiled-coil |
|
| chr1_+_26696348 Show fit | 28.64 |
ENST00000457599.6
|
AT-rich interaction domain 1A |
|
| chr10_+_28532744 Show fit | 26.98 |
ENST00000651598.1
ENST00000526722.1 ENST00000375646.5 |
WW domain containing adaptor with coiled-coil |
|
| chr13_-_30465224 Show fit | 26.72 |
ENST00000399494.5
|
high mobility group box 1 |
|
| chr8_+_26291758 Show fit | 25.33 |
ENST00000522535.5
ENST00000665949.1 |
protein phosphatase 2 regulatory subunit Balpha |
|
| chr17_+_38705243 Show fit | 24.36 |
ENST00000621332.5
|
MLLT6, PHD finger containing |
|
| chr10_+_87863595 Show fit | 24.16 |
ENST00000371953.8
|
phosphatase and tensin homolog |
|
| chr8_-_140635617 Show fit | 22.75 |
ENST00000220592.10
|
argonaute RISC catalytic component 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 25.8 | 128.8 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.4 | 62.2 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 3.9 | 50.5 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 9.2 | 46.1 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 1.9 | 42.8 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 6.1 | 42.7 | GO:1901297 | arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.7 | 42.4 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 1.5 | 42.0 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 1.5 | 40.9 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 9.5 | 38.2 | GO:2000426 | plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 224.5 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.7 | 124.4 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.5 | 108.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.4 | 106.9 | GO:0000785 | chromatin(GO:0000785) |
| 1.3 | 98.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.3 | 92.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 89.2 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.7 | 80.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 2.2 | 74.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.6 | 74.7 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 174.5 | GO:0042393 | histone binding(GO:0042393) |
| 4.7 | 151.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.6 | 99.5 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
| 0.1 | 95.1 | GO:0003723 | RNA binding(GO:0003723) |
| 1.8 | 66.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.2 | 62.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 59.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.1 | 59.1 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 2.7 | 58.6 | GO:0008494 | translation activator activity(GO:0008494) |
| 5.2 | 51.5 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 117.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.1 | 99.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.9 | 75.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 1.5 | 55.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.5 | 55.0 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.8 | 54.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.2 | 47.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.6 | 46.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 1.9 | 44.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.4 | 42.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 97.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.3 | 91.1 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 1.1 | 90.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.4 | 87.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 1.4 | 84.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 1.4 | 77.2 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.9 | 73.2 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 4.5 | 67.1 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 2.0 | 60.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 2.1 | 45.9 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |