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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SIX1_SIX3_SIX2
Z-value: 0.69
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Transcription factors associated with SIX1_SIX3_SIX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX3 | hg38_v1_chr2_+_44941695_44941708 | 0.49 | 1.6e-14 | Click! |
| SIX2 | hg38_v1_chr2_-_45009401_45009457 | 0.42 | 9.9e-11 | Click! |
| SIX1 | hg38_v1_chr14_-_60649449_60649490 | 0.15 | 3.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX1_SIX3_SIX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.9 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.0 | 15.3 | GO:0045596 | negative regulation of cell differentiation(GO:0045596) |
| 0.1 | 14.2 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.1 | 13.3 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.0 | 12.2 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.3 | 12.0 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.7 | 8.8 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 2.1 | 8.3 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 1.0 | 8.2 | GO:0015747 | urate transport(GO:0015747) |
| 0.2 | 8.2 | GO:0048665 | neuron fate specification(GO:0048665) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.2 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.1 | 17.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 13.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 13.9 | GO:0005884 | actin filament(GO:0005884) |
| 0.8 | 13.3 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.9 | 12.0 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 11.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 11.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 9.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 9.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.6 | 16.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.9 | 13.1 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.9 | 8.2 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.0 | 8.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 8.1 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.1 | 7.9 | GO:0016410 | N-acyltransferase activity(GO:0016410) |
| 0.0 | 7.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.3 | 7.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 6.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 7.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 5.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 5.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 4.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.6 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 11.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.5 | 8.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 8.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 7.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 7.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 6.3 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 6.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 5.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.7 | 5.1 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |