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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SIX4
Z-value: 0.44
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Transcription factors associated with SIX4
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_105940235 Show fit | 13.21 |
ENST00000390593.2
|
immunoglobulin heavy variable 6-1 |
|
| chr14_-_106324743 Show fit | 5.78 |
ENST00000390612.3
|
immunoglobulin heavy variable 4-28 |
|
| chr1_+_158930778 Show fit | 5.25 |
ENST00000458222.5
|
pyrin and HIN domain family member 1 |
|
| chr6_-_31736504 Show fit | 5.08 |
ENST00000616760.1
ENST00000375784.7 ENST00000375779.6 |
chloride intracellular channel 1 |
|
| chr14_-_106627685 Show fit | 4.81 |
ENST00000390629.3
|
immunoglobulin heavy variable 4-59 |
|
| chr10_+_10798570 Show fit | 4.64 |
ENST00000638035.1
ENST00000636488.1 |
CUGBP Elav-like family member 2 |
|
| chr15_-_21742799 Show fit | 4.32 |
ENST00000622410.2
|
novel protein, identical to IGHV4-4 |
|
| chr14_-_106235582 Show fit | 3.99 |
ENST00000390607.2
|
immunoglobulin heavy variable 3-21 |
|
| chr19_+_35031263 Show fit | 3.52 |
ENST00000640135.1
ENST00000596348.2 |
sodium voltage-gated channel beta subunit 1 |
|
| chr12_-_10130241 Show fit | 3.08 |
ENST00000353231.9
ENST00000525605.1 |
C-type lectin domain containing 7A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 27.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 5.6 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.1 | 4.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 4.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.6 | 3.5 | GO:0021966 | corticospinal neuron axon guidance(GO:0021966) |
| 0.4 | 2.9 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
| 0.1 | 1.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 1.8 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.0 | 1.8 | GO:0060706 | cell differentiation involved in embryonic placenta development(GO:0060706) |
| 0.3 | 1.6 | GO:0035645 | enteric smooth muscle cell differentiation(GO:0035645) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 5.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 5.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 3.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 2.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 2.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.3 | 1.8 | GO:1990357 | terminal web(GO:1990357) |
| 0.2 | 1.8 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.6 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 6.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 5.8 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 5.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 4.7 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.1 | 4.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.7 | 3.5 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.0 | 2.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 1.8 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 1.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.0 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.0 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 0.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.9 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 2.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.8 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.0 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |