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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SIX4

Z-value: 0.44

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
ENSG00000100625.9 SIX4

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr14_-_105940235 13.21 ENST00000390593.2
immunoglobulin heavy variable 6-1
chr14_-_106324743 5.78 ENST00000390612.3
immunoglobulin heavy variable 4-28
chr1_+_158930778 5.25 ENST00000458222.5
pyrin and HIN domain family member 1
chr6_-_31736504 5.08 ENST00000616760.1
ENST00000375784.7
ENST00000375779.6
chloride intracellular channel 1
chr14_-_106627685 4.81 ENST00000390629.3
immunoglobulin heavy variable 4-59
chr10_+_10798570 4.64 ENST00000638035.1
ENST00000636488.1
CUGBP Elav-like family member 2
chr15_-_21742799 4.32 ENST00000622410.2
novel protein, identical to IGHV4-4
chr14_-_106235582 3.99 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr19_+_35031263 3.52 ENST00000640135.1
ENST00000596348.2
sodium voltage-gated channel beta subunit 1
chr12_-_10130241 3.08 ENST00000353231.9
ENST00000525605.1
C-type lectin domain containing 7A
chr1_+_116754422 2.85 ENST00000369478.4
ENST00000369477.1
CD2 molecule
chr12_-_10130143 2.68 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
C-type lectin domain containing 7A
chr19_+_859654 1.92 ENST00000592860.2
ENST00000327726.11
complement factor D
chr6_-_41072529 1.92 ENST00000373154.6
ENST00000464633.5
ENST00000628419.2
ENST00000479950.5
ENST00000482515.5
O-acyl-ADP-ribose deacylase 1
chr6_-_41072456 1.88 ENST00000463088.5
ENST00000469104.5
ENST00000486443.5
O-acyl-ADP-ribose deacylase 1
chr1_-_183590876 1.83 ENST00000367536.5
neutrophil cytosolic factor 2
chr17_-_41528293 1.80 ENST00000455635.1
ENST00000361566.7
keratin 19
chr19_+_35329161 1.67 ENST00000341773.10
ENST00000600131.5
ENST00000595780.5
ENST00000597916.5
ENST00000593867.5
ENST00000600424.5
ENST00000599811.5
ENST00000536635.6
ENST00000085219.10
ENST00000544992.6
ENST00000419549.6
CD22 molecule
chrY_+_20575792 1.47 ENST00000382772.3
eukaryotic translation initiation factor 1A Y-linked
chr6_+_41072939 1.40 ENST00000341376.11
ENST00000353205.5
nuclear transcription factor Y subunit alpha
chr15_+_58987652 1.14 ENST00000348370.9
ENST00000559160.1
ring finger protein 111
chr14_-_106349792 1.13 ENST00000438142.3
immunoglobulin heavy variable 4-31
chr17_+_38870050 1.11 ENST00000318008.11
ENST00000435347.7
LIM and SH3 protein 1
chr12_-_57846686 1.09 ENST00000548823.1
ENST00000398073.7
CTD small phosphatase 2
chr22_-_38872206 1.05 ENST00000407418.8
ENST00000216083.6
chromobox 6
chr11_+_125592826 1.02 ENST00000529196.5
ENST00000392708.9
ENST00000649491.1
ENST00000531491.5
STT3 oligosaccharyltransferase complex catalytic subunit A
chr22_+_41833079 1.00 ENST00000612482.4
ENST00000361204.9
sterol regulatory element binding transcription factor 2
chr6_-_41072331 0.89 ENST00000424266.7
O-acyl-ADP-ribose deacylase 1
chr13_-_77918820 0.87 ENST00000646607.2
endothelin receptor type B
chr5_+_86617919 0.86 ENST00000247655.4
ENST00000509578.1
cytochrome c oxidase subunit 7C
chr1_-_37947010 0.84 ENST00000458109.6
ENST00000373024.8
ENST00000373023.6
inositol polyphosphate-5-phosphatase B
chr3_-_93973833 0.81 ENST00000348974.5
ENST00000647936.1
ENST00000394236.9
ENST00000407433.6
protein S
chr5_+_86617967 0.76 ENST00000515763.1
cytochrome c oxidase subunit 7C
chr2_+_85584402 0.75 ENST00000306384.5
vesicle associated membrane protein 5
chr13_-_77918788 0.71 ENST00000626030.1
endothelin receptor type B
chrY_+_20575716 0.70 ENST00000361365.7
eukaryotic translation initiation factor 1A Y-linked
chr11_+_64241053 0.69 ENST00000309366.9
ENST00000449942.6
ENST00000652762.2
FKBP prolyl isomerase 2
novel protein
chr1_-_113871665 0.63 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
protein tyrosine phosphatase non-receptor type 22
chr7_-_113919000 0.62 ENST00000284601.4
protein phosphatase 1 regulatory subunit 3A
chr1_-_37595927 0.59 ENST00000373062.8
G protein nucleolar 2
chr3_-_87276462 0.58 ENST00000561167.5
ENST00000560656.1
POU class 1 homeobox 1
chr2_+_74483067 0.57 ENST00000233623.11
ENST00000442235.6
ENST00000410003.5
tetratricopeptide repeat domain 31
chr1_-_77682639 0.56 ENST00000370801.8
ENST00000433749.5
zinc finger ZZ-type containing 3
chr11_+_33258304 0.55 ENST00000531504.5
ENST00000456517.2
homeodomain interacting protein kinase 3
chr15_+_40953463 0.53 ENST00000617768.5
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr13_-_48001265 0.52 ENST00000646932.1
ENST00000433022.1
ENST00000470760.2
ENST00000644338.1
ENST00000646602.1
succinate-CoA ligase ADP-forming subunit beta
chr3_-_184248935 0.51 ENST00000446569.1
ENST00000397676.8
ALG3 alpha-1,3- mannosyltransferase
chr19_+_50384323 0.51 ENST00000599857.7
ENST00000613923.6
ENST00000601098.6
ENST00000440232.7
ENST00000595904.6
ENST00000593887.1
DNA polymerase delta 1, catalytic subunit
chr7_+_97732046 0.51 ENST00000350485.8
ENST00000346867.4
ENST00000319273.10
tachykinin precursor 1
chr13_-_48001305 0.50 ENST00000643023.1
succinate-CoA ligase ADP-forming subunit beta
chr3_-_87276577 0.48 ENST00000344265.8
ENST00000350375.7
POU class 1 homeobox 1
chr11_+_118077009 0.45 ENST00000616579.4
ENST00000534111.5
transmembrane serine protease 4
chr3_-_49120785 0.44 ENST00000417901.5
ENST00000306026.5
ENST00000434032.6
ubiquitin specific peptidase 19
chr12_+_4720395 0.41 ENST00000252318.7
polypeptide N-acetylgalactosaminyltransferase 8
chr3_-_168095344 0.40 ENST00000309027.4
golgi integral membrane protein 4
chr5_-_1294989 0.39 ENST00000334602.10
ENST00000310581.10
telomerase reverse transcriptase
chr3_-_184249520 0.36 ENST00000455059.5
ENST00000445626.6
ALG3 alpha-1,3- mannosyltransferase
chrX_+_109537118 0.36 ENST00000372103.1
nuclear transport factor 2 like export factor 2
chr11_+_118077067 0.34 ENST00000522307.5
ENST00000523251.5
ENST00000437212.8
ENST00000522824.5
ENST00000522151.5
transmembrane serine protease 4
chr1_+_26410809 0.33 ENST00000254231.4
ENST00000326279.11
lin-28 homolog A
chr12_-_4379712 0.30 ENST00000237837.2
fibroblast growth factor 23
chr20_+_59300589 0.30 ENST00000337938.7
ENST00000371025.7
endothelin 3
chr20_+_59300402 0.30 ENST00000311585.11
ENST00000371028.6
endothelin 3
chr6_-_27872334 0.27 ENST00000616365.2
H3 clustered histone 11
chr17_+_7561899 0.24 ENST00000321337.12
SUMO specific peptidase 3
chr8_-_94895195 0.24 ENST00000308108.9
ENST00000396133.7
cyclin E2
chr1_-_16352420 0.21 ENST00000375592.8
F-box protein 42
chr9_-_92536031 0.20 ENST00000344604.9
ENST00000375540.5
extracellular matrix protein 2
chr1_+_152514474 0.18 ENST00000368790.4
cysteine rich C-terminal 1
chrX_-_120629936 0.17 ENST00000371313.2
ENST00000304661.6
C1GALT1 specific chaperone 1
chr20_+_59300547 0.17 ENST00000644821.1
endothelin 3
chr1_-_247172002 0.16 ENST00000491356.5
ENST00000472531.5
ENST00000340684.10
ENST00000543802.3
zinc finger protein 124
chrX_+_9560465 0.16 ENST00000647060.1
transducin beta like 1 X-linked
chr1_-_42335869 0.13 ENST00000372573.5
forkhead box J3
chrX_-_11665908 0.12 ENST00000337414.9
Rho GTPase activating protein 6
chr3_-_168095885 0.11 ENST00000470487.6
golgi integral membrane protein 4
chr16_+_590200 0.10 ENST00000563109.1
RAB40C, member RAS oncogene family
chr1_+_156642148 0.09 ENST00000361588.5
brevican
chr2_-_74482914 0.09 ENST00000290418.4
ENST00000393965.8
coiled-coil domain containing 142
chrX_+_71283186 0.08 ENST00000535149.5
non-POU domain containing octamer binding
chrX_+_54440396 0.07 ENST00000375151.5
TSR2 ribosome maturation factor
chr17_+_50561010 0.07 ENST00000360761.8
ENST00000354983.8
ENST00000352832.9
calcium voltage-gated channel subunit alpha1 G
chr11_+_2393831 0.06 ENST00000481687.1
CD81 molecule
chr16_-_53052849 0.06 ENST00000619363.2
novel protein
chr11_+_119067774 0.05 ENST00000621676.5
ENST00000614944.4
VPS11 core subunit of CORVET and HOPS complexes

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.4 2.9 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.4 27.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 1.0 GO:0006781 succinyl-CoA pathway(GO:0006781)
0.3 1.6 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
0.3 1.1 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.3 1.0 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.2 0.5 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.1 1.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.8 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.1 0.4 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.1 0.6 GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 4.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.5 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 1.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:1904383 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369) response to sodium phosphate(GO:1904383)
0.1 5.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 4.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.8 GO:0045730 respiratory burst(GO:0045730)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 1.8 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 0.9 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.6 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.9 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.4 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 1.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.6 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.1 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 22.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.3 1.8 GO:1990357 terminal web(GO:1990357)
0.3 1.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.8 GO:0032010 phagolysosome(GO:0032010)
0.1 3.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.4 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 1.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 2.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 5.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 2.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.5 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.4 22.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 1.0 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.3 0.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 1.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 1.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.2 1.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 1.6 GO:0004962 endothelin receptor activity(GO:0004962)
0.2 5.8 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 1.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.8 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 5.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.0 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 4.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.8 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 4.7 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.4 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.5 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 6.0 GO:0003823 antigen binding(GO:0003823)
0.0 2.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.0 1.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.4 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 1.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 2.9 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation