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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 2.03
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Transcription factors associated with SIX5_SMARCC2_HCFC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HCFC1 | hg38_v1_chrX_-_153971169_153971233, hg38_v1_chrX_-_153971810_153971844 | 0.41 | 4.4e-10 | Click! |
| SMARCC2 | hg38_v1_chr12_-_56189548_56189609 | 0.38 | 5.2e-09 | Click! |
| SIX5 | hg38_v1_chr19_-_45768843_45768869 | -0.37 | 2.5e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 115.2 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 12.3 | 110.3 | GO:2000580 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 1.4 | 107.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 13.5 | 94.3 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 5.8 | 69.2 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 3.3 | 69.0 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.6 | 66.0 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 4.3 | 60.6 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 4.6 | 59.9 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 1.4 | 55.1 | GO:0071174 | mitotic spindle checkpoint(GO:0071174) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 126.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 5.1 | 112.7 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.4 | 101.2 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 99.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 18.9 | 94.3 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 5.2 | 83.9 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.2 | 78.8 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 1.7 | 67.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.4 | 67.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 5.8 | 64.3 | GO:0070449 | elongin complex(GO:0070449) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 115.2 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 8.0 | 111.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 31.4 | 94.3 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 1.7 | 89.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.4 | 79.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 5.0 | 60.6 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.2 | 58.1 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 1.4 | 58.0 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 1.6 | 57.7 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 1.8 | 54.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 124.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 3.3 | 66.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 1.0 | 51.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.4 | 48.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 47.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.8 | 47.2 | PID ARF 3PATHWAY | Arf1 pathway |
| 1.9 | 43.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 1.6 | 39.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.7 | 39.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.6 | 31.3 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 161.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 5.0 | 131.2 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 1.5 | 108.0 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.1 | 100.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.1 | 85.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 2.6 | 73.3 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.8 | 63.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.9 | 58.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.6 | 54.8 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 2.0 | 47.7 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |