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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SIX6

Z-value: 0.75

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.7 SIX6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg38_v1_chr14_+_60509138_605091630.393.4e-09Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_65488735 22.72 ENST00000338957.4
ZC3H12B
zinc finger CCCH-type containing 12B
chr11_-_5227063 20.82 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr1_-_9943314 15.77 ENST00000377223.6
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr4_+_112818088 10.66 ENST00000673044.1
ENST00000672696.1
ENST00000672315.1
ENST00000672088.1
ENST00000671793.1
ENST00000672402.1
ENST00000671825.1
ENST00000672312.1
ENST00000672830.1
ENST00000672731.1
ENST00000671854.1
ENST00000672350.1
ENST00000672684.1
ENST00000672934.1
ENST00000673546.1
ENST00000673573.1
ENST00000503423.6
ENST00000673255.1
ENST00000671893.1
ENST00000672246.1
ENST00000672930.1
ENST00000673334.1
ENST00000673453.1
ENST00000673555.1
ENST00000672880.1
ENST00000672990.1
ENST00000673430.1
ENST00000673298.1
ENST00000672068.1
ENST00000672362.1
ENST00000672793.1
ENST00000672209.1
ENST00000671756.1
ENST00000671809.1
ENST00000671906.1
ENST00000672090.1
ENST00000672177.1
ENST00000672759.1
ENST00000672965.1
ENST00000673109.1
ENST00000503271.5
ENST00000506722.5
ENST00000673536.1
ENST00000672986.1
ANK2
ankyrin 2
chr4_+_112818032 10.59 ENST00000672356.1
ENST00000672955.1
ANK2
ankyrin 2
chr6_-_107824294 9.25 ENST00000369020.8
ENST00000369022.6
SCML4
Scm polycomb group protein like 4
chrX_+_8465426 9.10 ENST00000381029.4
VCX3B
variable charge X-linked 3B
chr2_-_88128049 7.47 ENST00000393750.3
ENST00000295834.8
FABP1
fatty acid binding protein 1
chrY_+_14056226 7.29 ENST00000250823.5
VCY1B
variable charge Y-linked 1B
chr1_-_35769958 7.13 ENST00000251195.9
ENST00000318121.8
CLSPN
claspin
chr12_-_121580954 7.00 ENST00000536437.5
ENST00000611216.4
ENST00000538046.6
ENST00000377071.9
KDM2B
lysine demethylase 2B
chr5_+_75512058 6.71 ENST00000514296.5
POLK
DNA polymerase kappa
chr11_+_74988896 6.10 ENST00000526068.1
ENST00000294064.9
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
NEU3
neuraminidase 3
chr14_-_69574845 6.06 ENST00000599174.3
CCDC177
coiled-coil domain containing 177
chrY_-_13986473 5.78 ENST00000250825.5
VCY
variable charge Y-linked
chr3_+_151814102 5.60 ENST00000232892.12
AADAC
arylacetamide deacetylase
chr19_-_14848922 5.56 ENST00000641129.1
OR7A10
olfactory receptor family 7 subfamily A member 10
chr1_+_160739265 5.40 ENST00000368042.7
SLAMF7
SLAM family member 7
chr4_-_69961007 4.84 ENST00000353151.3
CSN2
casein beta
chr1_+_160739239 4.77 ENST00000368043.8
SLAMF7
SLAM family member 7
chr2_-_151973780 4.76 ENST00000637514.1
ENST00000636350.1
ENST00000434468.2
ENST00000637762.1
ENST00000637779.1
ENST00000637547.1
ENST00000636901.1
ENST00000397327.7
ENST00000636721.1
ENST00000636380.1
ENST00000637284.1
ENST00000636617.1
ENST00000636947.1
ENST00000638091.1
ENST00000636108.1
ENST00000638040.1
ENST00000636773.1
ENST00000637418.1
ENST00000637216.1
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr9_-_21141832 4.58 ENST00000380229.4
IFNW1
interferon omega 1
chr1_-_161223408 4.50 ENST00000491350.1
APOA2
apolipoprotein A2
chr11_-_45286265 4.45 ENST00000020926.8
SYT13
synaptotagmin 13
chr6_+_29587455 4.27 ENST00000383640.4
OR2H2
olfactory receptor family 2 subfamily H member 2
chr5_-_177780633 4.21 ENST00000513554.5
ENST00000440605.7
FAM153A
family with sequence similarity 153 member A
chr3_+_8501846 4.19 ENST00000454244.4
LMCD1
LIM and cysteine rich domains 1
chr1_-_13347134 3.91 ENST00000334600.7
PRAMEF14
PRAME family member 14
chr6_+_26204552 3.83 ENST00000615164.2
H4C5
H4 clustered histone 5
chrX_-_18220878 3.71 ENST00000380033.9
BEND2
BEN domain containing 2
chr19_-_15898057 3.68 ENST00000011989.11
ENST00000221700.11
CYP4F2
cytochrome P450 family 4 subfamily F member 2
chr1_-_161223559 3.53 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr5_+_40909490 3.45 ENST00000313164.10
C7
complement C7
chr3_-_9952337 3.45 ENST00000411976.2
ENST00000412055.6
PRRT3
proline rich transmembrane protein 3
chr16_-_20352707 3.29 ENST00000396134.6
ENST00000573567.5
ENST00000570757.5
ENST00000396138.9
ENST00000571174.5
ENST00000576688.2
UMOD
uromodulin
chr4_-_154590735 3.28 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
FGA
fibrinogen alpha chain
chr21_-_18403754 3.18 ENST00000284885.8
TMPRSS15
transmembrane serine protease 15
chr1_+_156150008 3.17 ENST00000355014.6
SEMA4A
semaphorin 4A
chr6_-_26017779 3.16 ENST00000244573.5
H1-1
H1.1 linker histone, cluster member
chr12_+_71686473 3.14 ENST00000549735.5
TMEM19
transmembrane protein 19
chr7_+_117611617 3.14 ENST00000468795.1
CFTR
CF transmembrane conductance regulator
chr11_-_84273188 3.06 ENST00000330014.11
ENST00000418306.6
ENST00000531015.5
DLG2
discs large MAGUK scaffold protein 2
chrX_+_7843088 3.02 ENST00000341408.5
VCX
variable charge X-linked
chr9_-_21351378 3.01 ENST00000380210.1
IFNA6
interferon alpha 6
chr6_-_26189101 2.83 ENST00000614247.2
H4C4
H4 clustered histone 4
chr6_-_152637351 2.82 ENST00000367255.10
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr6_+_29396555 2.70 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr13_+_102656933 2.63 ENST00000650757.1
TPP2
tripeptidyl peptidase 2
chr1_+_86468902 2.60 ENST00000394711.2
CLCA1
chloride channel accessory 1
chr13_-_46105009 2.50 ENST00000439329.5
ENST00000674625.1
ENST00000181383.10
CPB2
carboxypeptidase B2
chr20_+_56412393 2.43 ENST00000679529.1
CASS4
Cas scaffold protein family member 4
chr13_+_73054969 2.37 ENST00000539231.5
KLF5
Kruppel like factor 5
chr1_+_160739286 2.27 ENST00000359331.8
ENST00000495334.1
SLAMF7
SLAM family member 7
chr5_+_161850597 2.23 ENST00000634335.1
ENST00000635880.1
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr4_-_154612635 2.15 ENST00000407946.5
ENST00000405164.5
ENST00000336098.8
ENST00000393846.6
ENST00000404648.7
ENST00000443553.5
FGG
fibrinogen gamma chain
chr12_-_21334858 2.11 ENST00000445053.1
ENST00000458504.5
ENST00000422327.5
ENST00000683939.1
SLCO1A2
solute carrier organic anion transporter family member 1A2
chr10_+_89301932 2.05 ENST00000371826.4
ENST00000679755.1
IFIT2
interferon induced protein with tetratricopeptide repeats 2
chr1_+_13585453 2.04 ENST00000487038.5
ENST00000475043.5
PDPN
podoplanin
chr14_+_22479521 2.03 ENST00000390483.1
TRAJ56
T cell receptor alpha joining 56
chr18_+_44680093 1.99 ENST00000426838.8
ENST00000677068.1
SETBP1
SET binding protein 1
chr8_+_2045037 1.99 ENST00000262113.9
MYOM2
myomesin 2
chr12_-_121039204 1.91 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr12_-_27970273 1.90 ENST00000542963.1
ENST00000535992.5
PTHLH
parathyroid hormone like hormone
chr19_+_840991 1.88 ENST00000234347.10
PRTN3
proteinase 3
chr12_-_121039236 1.88 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr10_-_102418748 1.83 ENST00000020673.6
PSD
pleckstrin and Sec7 domain containing
chr20_+_56412249 1.79 ENST00000679887.1
ENST00000434344.2
CASS4
Cas scaffold protein family member 4
chrX_-_119565362 1.78 ENST00000320339.8
ENST00000536133.2
ENST00000644802.2
STEEP1
STING1 ER exit protein 1
chr20_+_56412112 1.67 ENST00000360314.7
CASS4
Cas scaffold protein family member 4
chr8_+_100158029 1.67 ENST00000251809.4
SPAG1
sperm associated antigen 1
chr20_-_5010284 1.58 ENST00000379333.5
SLC23A2
solute carrier family 23 member 2
chr1_+_12791397 1.54 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr3_-_53882142 1.51 ENST00000335754.8
ACTR8
actin related protein 8
chr6_+_146027662 1.38 ENST00000492807.6
ENST00000361719.6
GRM1
glutamate metabotropic receptor 1
chr1_+_62597510 1.36 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr1_+_12857086 1.35 ENST00000240189.2
PRAMEF2
PRAME family member 2
chr6_+_52186373 1.33 ENST00000648244.1
IL17A
interleukin 17A
chrX_-_33211540 1.31 ENST00000357033.9
DMD
dystrophin
chr16_+_28637654 1.26 ENST00000529716.5
NPIPB8
nuclear pore complex interacting protein family member B8
chr3_+_187024614 1.24 ENST00000416235.6
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr18_+_52752032 1.21 ENST00000412726.5
ENST00000578080.1
ENST00000582875.1
DCC
DCC netrin 1 receptor
chr18_+_11752041 1.16 ENST00000423027.8
GNAL
G protein subunit alpha L
chr12_-_121039156 1.15 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr5_+_140821598 1.07 ENST00000614258.1
ENST00000529859.2
ENST00000529619.5
PCDHA5
protocadherin alpha 5
chr4_+_73436198 1.05 ENST00000395792.7
AFP
alpha fetoprotein
chr6_-_26043704 1.04 ENST00000615966.2
H2BC3
H2B clustered histone 3
chr19_+_3136026 0.98 ENST00000262958.4
GNA15
G protein subunit alpha 15
chr22_-_19150292 0.96 ENST00000086933.3
GSC2
goosecoid homeobox 2
chr4_+_77605807 0.94 ENST00000682537.1
CXCL13
C-X-C motif chemokine ligand 13
chr4_+_73436244 0.87 ENST00000226359.2
AFP
alpha fetoprotein
chr8_+_2045058 0.82 ENST00000523438.1
MYOM2
myomesin 2
chr1_+_197413827 0.79 ENST00000367397.1
ENST00000681519.1
CRB1
crumbs cell polarity complex component 1
chr12_-_10826358 0.78 ENST00000240619.2
TAS2R10
taste 2 receptor member 10
chr12_-_27970047 0.76 ENST00000395868.7
PTHLH
parathyroid hormone like hormone
chr12_-_121038967 0.73 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr19_-_35563653 0.71 ENST00000262623.4
ATP4A
ATPase H+/K+ transporting subunit alpha
chr6_+_29170907 0.64 ENST00000641417.1
OR2J2
olfactory receptor family 2 subfamily J member 2
chr8_+_24384275 0.62 ENST00000256412.8
ADAMDEC1
ADAM like decysin 1
chr1_-_38876351 0.46 ENST00000360786.3
GJA9
gap junction protein alpha 9
chr8_+_24384455 0.42 ENST00000522298.1
ADAMDEC1
ADAM like decysin 1
chr16_+_22513523 0.40 ENST00000538606.5
ENST00000451409.5
ENST00000424340.5
ENST00000517539.5
ENST00000528249.5
NPIPB5
nuclear pore complex interacting protein family member B5
chr17_-_10026265 0.36 ENST00000437099.6
ENST00000396115.6
GAS7
growth arrest specific 7
chr5_-_67196791 0.36 ENST00000256447.5
CD180
CD180 molecule
chr19_-_15125659 0.27 ENST00000533747.1
ENST00000598709.1
ENST00000534378.5
ILVBL
ilvB acetolactate synthase like
chr3_-_3109980 0.21 ENST00000256452.7
ENST00000311981.12
ENST00000430514.6
ENST00000456302.5
IL5RA
interleukin 5 receptor subunit alpha
chr6_+_26240385 0.20 ENST00000244537.6
H4C6
H4 clustered histone 6
chr6_-_26234978 0.20 ENST00000244534.7
H1-3
H1.3 linker histone, cluster member
chr4_-_122456725 0.19 ENST00000226730.5
IL2
interleukin 2
chr16_-_21857657 0.13 ENST00000341400.11
ENST00000518761.8
ENST00000682606.1
NPIPB4
nuclear pore complex interacting protein family member B4
chr11_-_102625332 0.07 ENST00000260228.3
MMP20
matrix metallopeptidase 20

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.8 GO:0030185 nitric oxide transport(GO:0030185)
2.3 7.0 GO:0021678 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
2.1 21.2 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.0 8.0 GO:2000909 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
1.6 4.8 GO:1903487 regulation of lactation(GO:1903487)
1.2 3.7 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
1.2 7.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.1 3.3 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
1.0 3.1 GO:1902161 transepithelial water transport(GO:0035377) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.8 6.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.7 2.0 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.7 7.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.6 2.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.5 5.6 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.4 7.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.4 2.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.3 1.3 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 1.9 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.3 0.9 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3 1.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.3 3.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 2.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.3 2.8 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.2 1.4 GO:0051005 negative regulation of phospholipase activity(GO:0010519) negative regulation of lipoprotein lipase activity(GO:0051005)
0.2 3.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.2 1.6 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.2 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 11.8 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 2.1 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 13.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 3.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 4.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 2.1 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 2.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.4 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 2.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 3.7 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.1 2.2 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.7 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 4.8 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 15.8 GO:0010212 response to ionizing radiation(GO:0010212)
0.1 0.2 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 1.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 22.7 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.1 5.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 1.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 3.1 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 2.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:2000317 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 0.7 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 3.0 GO:0042255 ribosome assembly(GO:0042255)
0.0 1.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.8 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 12.7 GO:0007420 brain development(GO:0007420)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 20.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.9 7.5 GO:0045179 apical cortex(GO:0045179)
0.6 3.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.5 8.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.5 5.4 GO:0005577 fibrinogen complex(GO:0005577)
0.4 3.5 GO:0005579 membrane attack complex(GO:0005579)
0.4 24.1 GO:0031430 M band(GO:0031430)
0.3 1.4 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.2 2.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 2.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 1.3 GO:0016013 syntrophin complex(GO:0016013)
0.1 7.0 GO:0031519 PcG protein complex(GO:0031519)
0.1 1.5 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 4.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.3 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 1.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.5 GO:0005903 brush border(GO:0005903)
0.0 1.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 4.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 11.3 GO:0016604 nuclear body(GO:0016604)
0.0 4.5 GO:0098793 presynapse(GO:0098793)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 20.8 GO:0030492 hemoglobin binding(GO:0030492)
2.0 6.1 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.6 8.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.2 3.7 GO:0097259 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
1.1 7.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.0 3.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
1.0 7.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.5 2.6 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.5 1.6 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.5 7.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.5 7.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.4 5.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.4 1.2 GO:0005042 netrin receptor activity(GO:0005042)
0.3 21.2 GO:0030507 spectrin binding(GO:0030507)
0.2 1.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 2.2 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 0.7 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.2 1.4 GO:0098960 postsynaptic neurotransmitter receptor activity(GO:0098960) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 6.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 5.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 3.3 GO:0019864 IgG binding(GO:0019864)
0.2 0.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 2.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 3.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 4.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 22.7 GO:0004519 endonuclease activity(GO:0004519)
0.1 2.0 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 13.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.8 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 2.1 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 15.8 GO:0008013 beta-catenin binding(GO:0008013)
0.1 2.8 GO:0005521 lamin binding(GO:0005521)
0.1 2.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.2 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 4.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.4 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 4.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 3.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.3 GO:0002162 dystroglycan binding(GO:0002162) vinculin binding(GO:0017166)
0.0 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 5.4 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 7.1 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 4.8 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 4.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 5.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 23.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 3.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 6.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 7.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 5.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 4.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.6 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 2.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 3.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 7.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 4.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 2.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation