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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SMAD1
Z-value: 3.16
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Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg38_v1_chr4_+_145481845_145481871, hg38_v1_chr4_+_145482761_145482820 | -0.52 | 1.3e-16 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.7 | 1027.8 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 6.8 | 635.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.2 | 376.7 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.8 | 257.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 18.6 | 149.0 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.8 | 144.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 2.5 | 138.4 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 13.7 | 137.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 7.2 | 136.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 11.8 | 129.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.0 | 913.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.5 | 642.5 | GO:0005615 | extracellular space(GO:0005615) |
| 17.9 | 340.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 329.8 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 2.1 | 313.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.5 | 187.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.7 | 179.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.6 | 159.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 24.8 | 149.0 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 2.6 | 142.2 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.0 | 1018.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 6.1 | 892.8 | GO:0003823 | antigen binding(GO:0003823) |
| 12.1 | 460.5 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.7 | 371.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 354.3 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.8 | 278.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 21.9 | 153.3 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 16.7 | 150.2 | GO:0043426 | MRF binding(GO:0043426) |
| 0.6 | 120.0 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 8.5 | 119.4 | GO:0019864 | IgG binding(GO:0019864) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 344.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 3.4 | 325.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 3.7 | 324.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.8 | 149.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 132.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.7 | 106.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.2 | 82.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.8 | 77.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 1.4 | 73.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 1.5 | 56.6 | PID BCR 5PATHWAY | BCR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 457.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 18.3 | 384.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.7 | 305.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 11.2 | 123.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.5 | 92.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 90.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.3 | 80.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 10.5 | 73.7 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.8 | 73.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.6 | 70.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |