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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SMAD2
Z-value: 0.68
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Transcription factors associated with SMAD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD2 | hg38_v1_chr18_-_47930630_47930681 | -0.33 | 6.1e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.2 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 6.0 | 18.0 | GO:0051941 | regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920) |
| 5.2 | 15.5 | GO:1904692 | positive regulation of type B pancreatic cell proliferation(GO:1904692) |
| 0.5 | 15.0 | GO:0014850 | response to muscle activity(GO:0014850) |
| 1.7 | 14.0 | GO:0070236 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 13.1 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 1.0 | 9.6 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 9.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.4 | 9.0 | GO:0032060 | bleb assembly(GO:0032060) |
| 1.3 | 8.8 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 24.7 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 1.0 | 18.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.3 | 10.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.7 | 9.6 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 9.6 | GO:0005938 | cell cortex(GO:0005938) |
| 0.3 | 9.0 | GO:0043218 | compact myelin(GO:0043218) |
| 0.4 | 8.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 8.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 6.6 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 1.4 | 18.0 | GO:1990239 | sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239) |
| 0.2 | 15.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 15.0 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 1.6 | 14.0 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 13.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 13.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 9.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.2 | 8.7 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.5 | 8.1 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.2 | 8.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 7.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 6.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 5.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 4.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 4.4 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 3.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 9.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 8.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 8.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 5.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 4.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 4.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 4.8 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.2 | 4.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |