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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SMAD2

Z-value: 0.68

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.16 SMAD2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg38_v1_chr18_-_47930630_47930681-0.336.1e-07Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_38561530 12.31 ENST00000378482.7
ENST00000286824.6
TSPAN7
tetraspanin 7
chr1_+_160115715 10.42 ENST00000361216.8
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chr17_-_10114546 9.99 ENST00000323816.8
GAS7
growth arrest specific 7
chr12_+_53050179 9.52 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
TNS2
tensin 2
chr17_-_15262537 9.01 ENST00000395936.7
ENST00000675819.1
ENST00000674707.1
ENST00000675854.1
ENST00000426385.4
ENST00000395938.7
ENST00000612492.5
ENST00000675808.1
PMP22
peripheral myelin protein 22
chr19_+_735026 8.76 ENST00000592155.5
ENST00000590161.2
PALM
paralemmin
chr5_-_151686908 8.46 ENST00000231061.9
SPARC
secreted protein acidic and cysteine rich
chr2_-_219308963 7.60 ENST00000423636.6
ENST00000442029.5
ENST00000412847.5
PTPRN
protein tyrosine phosphatase receptor type N
chr1_+_160127672 7.54 ENST00000447527.1
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chrX_-_107775740 7.25 ENST00000372383.9
TSC22D3
TSC22 domain family member 3
chrX_-_107775951 6.72 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family member 3
chrX_+_102651366 6.72 ENST00000415986.5
ENST00000444152.5
ENST00000361600.9
GPRASP1
G protein-coupled receptor associated sorting protein 1
chr5_+_141382702 6.06 ENST00000617050.1
ENST00000518325.2
PCDHGA7
protocadherin gamma subfamily A, 7
chr1_+_2050387 5.72 ENST00000378567.8
PRKCZ
protein kinase C zeta
chr22_+_19718390 5.65 ENST00000383045.7
ENST00000438754.6
SEPTIN5
septin 5
chr12_+_53050014 5.51 ENST00000314250.11
TNS2
tensin 2
chr7_+_29194757 5.33 ENST00000222792.11
CHN2
chimerin 2
chr19_+_35775515 4.95 ENST00000378944.9
ARHGAP33
Rho GTPase activating protein 33
chr4_-_5888400 4.91 ENST00000397890.6
CRMP1
collapsin response mediator protein 1
chr6_-_152168291 4.81 ENST00000354674.5
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr16_+_55479188 4.81 ENST00000219070.9
MMP2
matrix metallopeptidase 2
chr6_-_152168349 4.77 ENST00000539504.5
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr11_-_117295485 4.67 ENST00000680971.1
BACE1
beta-secretase 1
chr9_-_98708856 4.63 ENST00000259455.4
GABBR2
gamma-aminobutyric acid type B receptor subunit 2
chr19_+_35775530 4.63 ENST00000314737.9
ENST00000007510.8
ARHGAP33
Rho GTPase activating protein 33
chr6_+_39793008 4.57 ENST00000398904.6
DAAM2
dishevelled associated activator of morphogenesis 2
chr2_-_219309350 4.48 ENST00000295718.7
PTPRN
protein tyrosine phosphatase receptor type N
chr6_+_39792993 4.39 ENST00000538976.5
DAAM2
dishevelled associated activator of morphogenesis 2
chr12_-_55712402 4.39 ENST00000452168.6
ITGA7
integrin subunit alpha 7
chr6_+_39792298 4.23 ENST00000633794.1
ENST00000274867.9
DAAM2
dishevelled associated activator of morphogenesis 2
chr12_-_6689244 4.07 ENST00000361959.7
ENST00000436774.6
ENST00000544482.1
ZNF384
zinc finger protein 384
chr12_-_6689359 3.96 ENST00000683879.1
ZNF384
zinc finger protein 384
chr22_+_22822658 3.91 ENST00000620395.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr9_-_133131109 3.85 ENST00000372062.8
RALGDS
ral guanine nucleotide dissociation stimulator
chr3_-_168095885 3.79 ENST00000470487.6
GOLIM4
golgi integral membrane protein 4
chr16_+_90022600 3.77 ENST00000620723.4
ENST00000268699.9
GAS8
growth arrest specific 8
chr11_-_66317037 3.77 ENST00000311330.4
CD248
CD248 molecule
chr19_+_49513154 3.73 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr19_+_11355386 3.67 ENST00000251473.9
ENST00000591329.5
ENST00000586380.5
PLPPR2
phospholipid phosphatase related 2
chr22_+_22357739 3.67 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr22_+_22327298 3.67 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr19_-_14496088 3.58 ENST00000393033.9
ENST00000345425.6
ENST00000586027.5
ENST00000591349.5
ENST00000587210.1
GIPC1
GIPC PDZ domain containing family member 1
chr1_-_206946448 3.50 ENST00000356495.5
PIGR
polymeric immunoglobulin receptor
chr3_+_124094663 3.47 ENST00000460856.5
ENST00000240874.7
KALRN
kalirin RhoGEF kinase
chr12_-_6689450 3.45 ENST00000355772.8
ENST00000417772.7
ENST00000319770.7
ENST00000396801.7
ZNF384
zinc finger protein 384
chr2_-_219309484 3.42 ENST00000409251.7
ENST00000451506.5
ENST00000446182.5
PTPRN
protein tyrosine phosphatase receptor type N
chr19_-_14496144 3.38 ENST00000393028.5
GIPC1
GIPC PDZ domain containing family member 1
chr7_-_102517755 3.37 ENST00000306682.6
ENST00000465829.6
ENST00000541662.5
RASA4B
RAS p21 protein activator 4B
chr9_+_15422704 3.37 ENST00000380821.7
ENST00000610884.4
ENST00000421710.5
SNAPC3
small nuclear RNA activating complex polypeptide 3
chr7_-_102616692 3.20 ENST00000521076.5
ENST00000462172.5
ENST00000522801.5
ENST00000262940.12
ENST00000449970.6
RASA4
RAS p21 protein activator 4
chr7_-_100896123 3.11 ENST00000428317.7
ACHE
acetylcholinesterase (Cartwright blood group)
chr1_+_159171607 3.11 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr22_-_20016807 3.08 ENST00000263207.8
ARVCF
ARVCF delta catenin family member
chr3_+_52495330 3.05 ENST00000321725.10
STAB1
stabilin 1
chr13_-_96053370 3.03 ENST00000376712.4
ENST00000397618.7
ENST00000376747.8
ENST00000376714.7
ENST00000638479.1
ENST00000621375.5
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr9_+_101028721 3.01 ENST00000374874.8
PLPPR1
phospholipid phosphatase related 1
chr19_-_6481769 3.00 ENST00000381480.7
ENST00000543576.5
ENST00000590173.5
DENND1C
DENN domain containing 1C
chrX_-_63754664 3.00 ENST00000677315.1
ENST00000636392.1
ENST00000637040.1
ENST00000637178.1
ENST00000637557.1
ENST00000636048.1
ENST00000638021.1
ENST00000672513.1
ENSG00000288661.1
ARHGEF9
novel protein
Cdc42 guanine nucleotide exchange factor 9
chr11_-_33892010 2.84 ENST00000257818.3
LMO2
LIM domain only 2
chr1_+_43946905 2.80 ENST00000372343.8
IPO13
importin 13
chr13_-_26760741 2.74 ENST00000405846.5
GPR12
G protein-coupled receptor 12
chr19_+_16888991 2.74 ENST00000248076.4
F2RL3
F2R like thrombin or trypsin receptor 3
chr6_+_31615215 2.65 ENST00000337917.11
ENST00000376059.8
AIF1
allograft inflammatory factor 1
chr17_+_3723889 2.59 ENST00000325418.5
HASPIN
histone H3 associated protein kinase
chr17_-_4142963 2.59 ENST00000381638.7
ZZEF1
zinc finger ZZ-type and EF-hand domain containing 1
chr16_-_4801301 2.47 ENST00000586504.5
ENST00000649556.1
ROGDI
ENSG00000285952.1
rogdi atypical leucine zipper
novel transcript
chr20_-_17682234 2.47 ENST00000377813.6
ENST00000377807.6
ENST00000360807.8
ENST00000398782.2
RRBP1
ribosome binding protein 1
chr2_-_60550900 2.44 ENST00000643222.1
ENST00000643459.1
ENST00000489516.7
BCL11A
BAF chromatin remodeling complex subunit BCL11A
chrX_+_48801949 2.36 ENST00000376610.6
ENST00000462730.5
ENST00000376619.6
ENST00000465269.5
ENST00000334136.11
ENST00000476625.5
ENST00000646703.1
HDAC6
histone deacetylase 6
chr14_+_100726883 2.36 ENST00000341267.9
ENST00000331224.10
ENST00000556051.1
DLK1
delta like non-canonical Notch ligand 1
chr20_+_44715360 2.32 ENST00000190983.5
CCN5
cellular communication network factor 5
chr16_+_2148603 2.28 ENST00000210187.11
RAB26
RAB26, member RAS oncogene family
chr1_-_201946571 2.26 ENST00000616739.1
LMOD1
leiomodin 1
chr8_-_95269190 2.26 ENST00000286688.6
C8orf37
chromosome 8 open reading frame 37
chr15_+_45587366 2.25 ENST00000220531.9
BLOC1S6
biogenesis of lysosomal organelles complex 1 subunit 6
chr6_-_56954747 2.21 ENST00000680361.1
DST
dystonin
chr7_+_66629078 2.16 ENST00000449064.6
ENST00000638540.1
ENST00000640234.1
KCTD7
potassium channel tetramerization domain containing 7
chr3_-_195876635 2.15 ENST00000672669.1
ENST00000672886.1
ENST00000672098.1
ENST00000671767.1
ENST00000672548.1
TNK2
tyrosine kinase non receptor 2
chr13_-_26222255 2.14 ENST00000381588.9
RNF6
ring finger protein 6
chr1_+_27726005 2.13 ENST00000530324.5
ENST00000234549.11
ENST00000373949.5
ENST00000010299.10
FAM76A
family with sequence similarity 76 member A
chr19_+_48469354 2.11 ENST00000452733.7
ENST00000641098.1
CYTH2
cytohesin 2
chr7_+_66629023 2.06 ENST00000639879.1
ENST00000640851.1
KCTD7
potassium channel tetramerization domain containing 7
chr16_+_28878480 2.06 ENST00000395503.9
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr1_+_36306359 2.06 ENST00000453908.8
SH3D21
SH3 domain containing 21
chrX_+_153764178 2.02 ENST00000538966.5
PLXNB3
plexin B3
chr11_+_14643826 2.02 ENST00000455098.2
PDE3B
phosphodiesterase 3B
chr22_-_38455199 2.02 ENST00000303592.3
KCNJ4
potassium inwardly rectifying channel subfamily J member 4
chr5_-_74640575 2.00 ENST00000651128.1
ENC1
ectodermal-neural cortex 1
chr1_+_27725945 1.95 ENST00000373954.11
ENST00000419687.6
FAM76A
family with sequence similarity 76 member A
chr21_-_37267511 1.93 ENST00000398998.1
VPS26C
VPS26 endosomal protein sorting factor C
chr15_+_45587580 1.92 ENST00000566801.5
ENST00000565323.6
ENST00000568816.5
BLOC1S6
biogenesis of lysosomal organelles complex 1 subunit 6
chr6_+_101393699 1.91 ENST00000369134.9
ENST00000684068.1
ENST00000683903.1
ENST00000681975.1
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr1_+_36307090 1.91 ENST00000505871.7
SH3D21
SH3 domain containing 21
chr22_+_41560973 1.88 ENST00000306149.12
CSDC2
cold shock domain containing C2
chrX_+_48802156 1.87 ENST00000643374.1
ENST00000644068.1
ENST00000441703.6
ENST00000643934.1
ENST00000489352.5
HDAC6
histone deacetylase 6
chr1_-_151146643 1.87 ENST00000613223.1
SEMA6C
semaphorin 6C
chr1_-_151146611 1.84 ENST00000341697.7
ENST00000368914.8
SEMA6C
semaphorin 6C
chr12_-_10098977 1.82 ENST00000315330.8
ENST00000457018.6
CLEC1A
C-type lectin domain family 1 member A
chr22_-_24245059 1.81 ENST00000398292.3
ENST00000263112.11
ENST00000327365.10
ENST00000424217.1
GGT5
gamma-glutamyltransferase 5
chr2_+_27014746 1.80 ENST00000648289.1
ENST00000458529.5
ENST00000402218.1
MAPRE3
microtubule associated protein RP/EB family member 3
chr1_-_201946469 1.74 ENST00000367288.5
LMOD1
leiomodin 1
chr7_+_102363874 1.74 ENST00000496391.5
PRKRIP1
PRKR interacting protein 1
chr16_-_4937064 1.72 ENST00000590782.6
ENST00000345988.7
PPL
periplakin
chr3_+_124094696 1.70 ENST00000360013.7
ENST00000684186.1
ENST00000684276.1
KALRN
kalirin RhoGEF kinase
chr7_-_14841267 1.68 ENST00000406247.7
ENST00000399322.7
DGKB
diacylglycerol kinase beta
chr2_-_219243577 1.65 ENST00000409640.5
GLB1L
galactosidase beta 1 like
chrX_+_153494970 1.65 ENST00000331595.9
ENST00000431891.1
BGN
biglycan
chr6_+_32164586 1.63 ENST00000333845.11
ENST00000395512.5
ENST00000432129.1
EGFL8
EGF like domain multiple 8
chr20_-_23086316 1.59 ENST00000246006.5
CD93
CD93 molecule
chrX_-_100732100 1.55 ENST00000372981.1
ENST00000263033.9
SYTL4
synaptotagmin like 4
chr1_-_44017296 1.54 ENST00000357730.6
ENST00000360584.6
ENST00000528803.1
SLC6A9
solute carrier family 6 member 9
chr22_+_37639660 1.48 ENST00000649765.2
ENST00000451997.6
SH3BP1
ENSG00000285304.1
SH3 domain binding protein 1
novel protein
chr4_-_121952014 1.42 ENST00000379645.8
TRPC3
transient receptor potential cation channel subfamily C member 3
chr1_-_234479131 1.42 ENST00000040877.2
TARBP1
TAR (HIV-1) RNA binding protein 1
chr19_+_11355491 1.41 ENST00000591608.1
PLPPR2
phospholipid phosphatase related 2
chr2_-_227164194 1.40 ENST00000396625.5
COL4A4
collagen type IV alpha 4 chain
chr8_-_20303955 1.39 ENST00000381569.5
LZTS1
leucine zipper tumor suppressor 1
chrX_+_153764233 1.38 ENST00000361971.10
PLXNB3
plexin B3
chr11_+_14643782 1.37 ENST00000282096.9
PDE3B
phosphodiesterase 3B
chr1_-_44031352 1.28 ENST00000372306.7
ENST00000475075.6
SLC6A9
solute carrier family 6 member 9
chr12_-_57016517 1.26 ENST00000441881.5
ENST00000458521.7
TAC3
tachykinin precursor 3
chr17_+_7705193 1.23 ENST00000226091.3
EFNB3
ephrin B3
chr7_+_155458129 1.19 ENST00000297375.4
EN2
engrailed homeobox 2
chr13_-_26221703 1.19 ENST00000381570.7
ENST00000346166.7
RNF6
ring finger protein 6
chr5_-_151141631 1.18 ENST00000523714.5
ENST00000521749.5
ANXA6
annexin A6
chr16_+_2033264 1.17 ENST00000565855.5
ENST00000566198.1
SLC9A3R2
SLC9A3 regulator 2
chr12_-_12266769 1.17 ENST00000543091.1
LRP6
LDL receptor related protein 6
chr20_+_45469745 1.13 ENST00000372676.8
ENST00000217425.9
ENST00000339946.7
WFDC2
WAP four-disulfide core domain 2
chr12_+_3491189 1.07 ENST00000382622.4
PRMT8
protein arginine methyltransferase 8
chr17_-_3668640 1.07 ENST00000611779.4
TAX1BP3
Tax1 binding protein 3
chr7_-_100895878 1.06 ENST00000419336.6
ENST00000241069.11
ENST00000411582.4
ENST00000302913.8
ACHE
acetylcholinesterase (Cartwright blood group)
chr14_+_80955577 1.01 ENST00000642209.1
ENST00000298171.7
TSHR
thyroid stimulating hormone receptor
chr1_-_39639626 0.98 ENST00000372852.4
HEYL
hes related family bHLH transcription factor with YRPW motif like
chr9_-_128067310 0.95 ENST00000373078.5
NAIF1
nuclear apoptosis inducing factor 1
chr3_+_40505992 0.95 ENST00000420891.5
ENST00000314529.10
ENST00000418905.1
ZNF620
zinc finger protein 620
chr18_+_13218195 0.92 ENST00000679167.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr17_-_3668557 0.92 ENST00000225525.4
TAX1BP3
Tax1 binding protein 3
chr22_+_24495242 0.92 ENST00000382760.2
ENST00000326010.10
UPB1
beta-ureidopropionase 1
chr14_+_101964561 0.91 ENST00000643508.2
ENST00000680137.1
ENST00000644881.2
ENST00000645149.2
ENST00000681574.1
ENST00000360184.10
ENST00000679720.1
ENST00000645114.2
DYNC1H1
dynein cytoplasmic 1 heavy chain 1
chr1_+_15456727 0.91 ENST00000359621.5
CELA2A
chymotrypsin like elastase 2A
chr2_+_167868948 0.89 ENST00000392690.3
B3GALT1
beta-1,3-galactosyltransferase 1
chr5_+_134526100 0.88 ENST00000395003.5
JADE2
jade family PHD finger 2
chr6_+_41042557 0.83 ENST00000373158.6
ENST00000470917.1
TSPO2
translocator protein 2
chr11_-_126062782 0.82 ENST00000531738.6
CDON
cell adhesion associated, oncogene regulated
chr16_+_57668299 0.81 ENST00000333493.9
ENST00000450388.7
ADGRG3
adhesion G protein-coupled receptor G3
chr16_+_28878382 0.79 ENST00000357084.7
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr9_+_122375286 0.78 ENST00000373698.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_-_134917872 0.75 ENST00000616356.4
ENST00000371806.4
FCN1
ficolin 1
chr19_-_43781249 0.73 ENST00000615047.4
KCNN4
potassium calcium-activated channel subfamily N member 4
chr12_-_52814106 0.71 ENST00000551956.2
KRT4
keratin 4
chr12_+_49961864 0.65 ENST00000293599.7
AQP5
aquaporin 5
chr7_+_130380339 0.65 ENST00000481342.5
ENST00000604896.5
ENST00000011292.8
CPA1
carboxypeptidase A1
chr19_-_40882226 0.63 ENST00000301146.9
CYP2A7
cytochrome P450 family 2 subfamily A member 7
chr19_-_51646800 0.60 ENST00000599649.5
ENST00000429354.3
ENST00000360844.6
SIGLEC5
SIGLEC14
sialic acid binding Ig like lectin 5
sialic acid binding Ig like lectin 14
chr4_+_92303946 0.59 ENST00000282020.9
GRID2
glutamate ionotropic receptor delta type subunit 2
chr14_+_22226711 0.56 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr1_+_37474572 0.55 ENST00000373087.7
ZC3H12A
zinc finger CCCH-type containing 12A
chr20_+_1895365 0.54 ENST00000358771.5
SIRPA
signal regulatory protein alpha
chr2_-_73284431 0.54 ENST00000521871.5
ENST00000520530.3
FBXO41
F-box protein 41
chrX_-_30577759 0.53 ENST00000378962.4
TASL
TLR adaptor interacting with endolysosomal SLC15A4
chr5_-_88731827 0.49 ENST00000627170.2
MEF2C
myocyte enhancer factor 2C
chr19_+_48624952 0.49 ENST00000599748.5
ENST00000599029.2
SPHK2
sphingosine kinase 2
chr14_+_80955366 0.47 ENST00000342443.10
TSHR
thyroid stimulating hormone receptor
chr19_+_35936360 0.45 ENST00000246529.4
LRFN3
leucine rich repeat and fibronectin type III domain containing 3
chrX_-_20141810 0.45 ENST00000379593.1
ENST00000379607.10
EIF1AX
eukaryotic translation initiation factor 1A X-linked
chr10_+_71212524 0.44 ENST00000335350.10
UNC5B
unc-5 netrin receptor B
chr10_-_124093582 0.44 ENST00000462406.1
ENST00000435907.6
CHST15
carbohydrate sulfotransferase 15
chr1_+_16367088 0.42 ENST00000471507.5
ENST00000401089.3
ENST00000401088.9
ENST00000492354.1
SZRD1
SUZ RNA binding domain containing 1
chr17_+_42288429 0.41 ENST00000676631.1
ENST00000677893.1
STAT5A
signal transducer and activator of transcription 5A
chr15_-_73368951 0.39 ENST00000261917.4
HCN4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
chr17_-_42185452 0.38 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr19_-_51630401 0.38 ENST00000683636.1
SIGLEC5
sialic acid binding Ig like lectin 5
chr19_-_14114156 0.36 ENST00000589994.6
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
chr1_+_2476284 0.34 ENST00000378486.8
PLCH2
phospholipase C eta 2
chr4_-_41214535 0.33 ENST00000508593.6
APBB2
amyloid beta precursor protein binding family B member 2
chr1_+_26159071 0.31 ENST00000374268.5
FAM110D
family with sequence similarity 110 member D
chr9_+_79572715 0.31 ENST00000265284.10
TLE4
TLE family member 4, transcriptional corepressor
chr22_+_37560472 0.25 ENST00000430687.1
ENST00000249014.5
CDC42EP1
CDC42 effector protein 1
chr11_-_107719657 0.24 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr3_-_9792404 0.24 ENST00000301964.7
TADA3
transcriptional adaptor 3
chr1_-_160070150 0.21 ENST00000644903.1
KCNJ10
potassium inwardly rectifying channel subfamily J member 10
chr22_-_36028773 0.19 ENST00000438146.7
RBFOX2
RNA binding fox-1 homolog 2
chr3_-_165196369 0.18 ENST00000475390.2
SLITRK3
SLIT and NTRK like family member 3
chr12_-_10098940 0.16 ENST00000420265.2
CLEC1A
C-type lectin domain family 1 member A
chr9_+_79573162 0.12 ENST00000425506.5
TLE4
TLE family member 4, transcriptional corepressor
chr1_+_99646025 0.12 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
PALMD
palmdelphin
chr11_-_22625804 0.11 ENST00000327470.6
FANCF
FA complementation group F
chr5_+_134526176 0.11 ENST00000681820.1
ENST00000512386.6
ENST00000612830.2
JADE2
jade family PHD finger 2
chr13_-_41961078 0.09 ENST00000379310.8
ENST00000281496.6
VWA8
von Willebrand factor A domain containing 8
chr1_-_160070102 0.07 ENST00000638728.1
ENST00000637644.1
KCNJ10
potassium inwardly rectifying channel subfamily J member 10
chr11_+_59755427 0.04 ENST00000529177.5
STX3
syntaxin 3
chr20_+_37346128 0.02 ENST00000373578.7
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
chr17_-_41424583 0.01 ENST00000225550.4
KRT37
keratin 37

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 18.0 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
5.2 15.5 GO:1904692 positive regulation of type B pancreatic cell proliferation(GO:1904692)
1.7 14.0 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
1.4 4.2 GO:0070845 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
1.4 4.2 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
1.3 8.8 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
1.2 3.7 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
1.2 8.5 GO:0033591 response to L-ascorbic acid(GO:0033591)
1.2 3.5 GO:0002415 immunoglobulin transcytosis in epithelial cells(GO:0002414) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.1 5.7 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
1.0 3.0 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
1.0 4.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
1.0 9.6 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.9 2.8 GO:0031448 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.9 2.8 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.9 5.6 GO:1904526 regulation of microtubule binding(GO:1904526)
0.7 4.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.7 3.3 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.6 2.4 GO:1904799 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.6 5.2 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.5 2.6 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.5 15.0 GO:0014850 response to muscle activity(GO:0014850)
0.4 9.0 GO:0032060 bleb assembly(GO:0032060)
0.4 1.2 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.4 3.4 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.4 3.4 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.4 1.5 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.4 1.4 GO:0000451 rRNA 2'-O-methylation(GO:0000451)
0.3 2.7 GO:0060155 platelet dense granule organization(GO:0060155)
0.3 0.9 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 1.4 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.3 4.2 GO:0016081 synaptic vesicle docking(GO:0016081)
0.3 3.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.3 0.8 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.2 0.7 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 7.0 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 3.8 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.2 1.0 GO:0072014 proximal tubule development(GO:0072014)
0.2 2.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.5 GO:0010587 miRNA catabolic process(GO:0010587) negative regulation by host of viral genome replication(GO:0044828)
0.2 0.9 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.2 2.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 0.8 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.2 1.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.3 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 1.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 1.8 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 1.2 GO:0016198 axon choice point recognition(GO:0016198)
0.1 7.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 2.8 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.5 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1 6.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.7 GO:0046541 saliva secretion(GO:0046541)
0.1 0.8 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 4.6 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 1.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 13.1 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 5.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 0.9 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.6 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) positive regulation of long term synaptic depression(GO:1900454)
0.1 1.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 4.7 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.1 1.2 GO:1990403 embryonic brain development(GO:1990403)
0.1 4.4 GO:0035987 endodermal cell differentiation(GO:0035987)
0.1 0.2 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 2.0 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.1 2.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.4 GO:0046449 creatinine metabolic process(GO:0046449)
0.1 2.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.9 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 9.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 7.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 3.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.2 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 1.4 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 18.2 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 2.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.4 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.0 0.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 3.0 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.4 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 3.3 GO:0070268 cornification(GO:0070268)
0.0 0.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 2.5 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724) definitive erythrocyte differentiation(GO:0060318)
0.0 1.6 GO:0042116 macrophage activation(GO:0042116)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 3.0 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 0.9 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 4.2 GO:0051260 protein homooligomerization(GO:0051260)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
1.2 4.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.0 18.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.7 9.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.7 5.7 GO:0045179 apical cortex(GO:0045179)
0.4 2.2 GO:0031673 H zone(GO:0031673)
0.4 8.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.4 6.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 2.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.3 4.2 GO:0043083 synaptic cleft(GO:0043083)
0.3 10.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 4.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 9.0 GO:0043218 compact myelin(GO:0043218)
0.2 3.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 1.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 25.1 GO:0008021 synaptic vesicle(GO:0008021)
0.1 0.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 2.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 2.6 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 5.2 GO:0030286 dynein complex(GO:0030286)
0.1 3.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 4.4 GO:0008305 integrin complex(GO:0008305)
0.1 4.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 3.8 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 1.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 2.6 GO:0097546 ciliary base(GO:0097546)
0.1 3.8 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.7 GO:0030057 desmosome(GO:0030057)
0.1 3.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 3.1 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 4.9 GO:0030496 midbody(GO:0030496)
0.0 0.6 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 9.6 GO:0005938 cell cortex(GO:0005938)
0.0 3.9 GO:0005903 brush border(GO:0005903)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 3.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 5.8 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 3.0 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 0.8 GO:0035579 specific granule membrane(GO:0035579)
0.0 2.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.2 GO:0001650 fibrillar center(GO:0001650)
0.0 8.6 GO:0005925 focal adhesion(GO:0005925)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 6.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 24.7 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 5.9 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.4 GO:0009986 cell surface(GO:0009986)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.0 GO:0043426 MRF binding(GO:0043426)
1.4 18.0 GO:1990239 sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239)
1.2 4.7 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
1.2 4.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.1 3.4 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
1.0 4.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.9 3.7 GO:0019770 IgG receptor activity(GO:0019770)
0.9 3.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.8 4.2 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.7 2.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.5 8.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.5 3.4 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.5 1.4 GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039)
0.5 2.7 GO:0015057 thrombin receptor activity(GO:0015057)
0.4 1.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.3 9.6 GO:0005521 lamin binding(GO:0005521)
0.3 3.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 1.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 15.5 GO:0030507 spectrin binding(GO:0030507)
0.2 5.7 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.2 1.0 GO:0035939 microsatellite binding(GO:0035939)
0.2 8.7 GO:0050780 dopamine receptor binding(GO:0050780)
0.2 1.6 GO:0001849 complement component C1q binding(GO:0001849)
0.2 4.9 GO:0031005 filamin binding(GO:0031005)
0.2 1.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.5 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.2 1.7 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 2.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 13.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 5.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 4.0 GO:0005523 tropomyosin binding(GO:0005523)
0.2 0.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 4.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 1.8 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 2.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.4 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 1.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 1.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.8 GO:0033691 sialic acid binding(GO:0033691)
0.1 2.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 0.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 7.0 GO:0017022 myosin binding(GO:0017022)
0.1 0.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 3.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.5 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 6.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 2.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 15.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 23.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 0.9 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 2.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.3 GO:0050681 androgen receptor binding(GO:0050681)
0.0 13.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0015250 water channel activity(GO:0015250)
0.0 1.0 GO:0035198 miRNA binding(GO:0035198)
0.0 2.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.6 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.6 GO:0005234 ionotropic glutamate receptor activity(GO:0004970) extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 3.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 7.0 GO:0008017 microtubule binding(GO:0008017)
0.0 4.6 GO:0051015 actin filament binding(GO:0051015)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.9 PID RAS PATHWAY Regulation of Ras family activation
0.2 5.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.2 2.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 7.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 4.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 3.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 9.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.1 PID ARF 3PATHWAY Arf1 pathway
0.1 5.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 3.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.8 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 3.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 7.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 6.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 3.5 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 2.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 4.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 3.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 4.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 9.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 4.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 4.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 4.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 3.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 3.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 8.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.7 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 4.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 5.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 8.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 4.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis