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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SMAD3
Z-value: 0.79
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Transcription factors associated with SMAD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD3 | hg38_v1_chr15_+_67128103_67128269 | 0.19 | 4.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 21.1 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 1.4 | 14.0 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 2.3 | 11.7 | GO:0090131 | mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131) |
| 1.0 | 8.8 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 1.2 | 7.2 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.0 | 6.6 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 6.1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.1 | 4.9 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.4 | 3.9 | GO:0021633 | optic nerve structural organization(GO:0021633) |
| 0.1 | 3.9 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.6 | GO:0031514 | motile cilium(GO:0031514) |
| 0.6 | 14.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 12.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 3.9 | 11.7 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.3 | 6.9 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.2 | 3.9 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.0 | 3.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 3.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.2 | 3.3 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 3.3 | GO:0035579 | specific granule membrane(GO:0035579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.1 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.7 | 14.0 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 1.2 | 10.4 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.6 | 8.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 8.1 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.3 | 7.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.6 | 7.1 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 1.2 | 6.1 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 4.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 3.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 14.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 7.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 4.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.2 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 3.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 2.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 7.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 3.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 3.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 3.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 3.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 3.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 3.1 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.2 | 2.5 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 2.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |