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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX10_SOX15
Z-value: 0.92
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Transcription factors associated with SOX10_SOX15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX15 | hg38_v1_chr17_-_7590072_7590101 | -0.54 | 8.3e-18 | Click! |
| SOX10 | hg38_v1_chr22_-_37984534_37984562 | -0.48 | 9.1e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX10_SOX15
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_10123171 Show fit | 30.27 |
ENST00000615152.5
|
ribonucleotide reductase regulatory subunit M2 |
|
| chr2_+_10122730 Show fit | 28.30 |
ENST00000304567.10
|
ribonucleotide reductase regulatory subunit M2 |
|
| chr11_-_102452758 Show fit | 21.66 |
ENST00000398136.7
ENST00000361236.7 |
transmembrane protein 123 |
|
| chr8_-_80080816 Show fit | 20.78 |
ENST00000520527.5
ENST00000517427.5 ENST00000379097.7 ENST00000448733.3 |
tumor protein D52 |
|
| chr13_+_30427950 Show fit | 20.42 |
ENST00000436446.1
|
ubiquitin conjugating enzyme E2 L5 |
|
| chr6_+_113857333 Show fit | 20.30 |
ENST00000612661.2
|
myristoylated alanine rich protein kinase C substrate |
|
| chr2_+_231708511 Show fit | 19.05 |
ENST00000341369.11
ENST00000409115.8 ENST00000409683.5 |
prothymosin alpha |
|
| chr4_-_156971769 Show fit | 18.44 |
ENST00000502773.6
|
platelet derived growth factor C |
|
| chr13_-_41019289 Show fit | 18.01 |
ENST00000239882.7
|
E74 like ETS transcription factor 1 |
|
| chr6_-_106975452 Show fit | 16.08 |
ENST00000619869.1
ENST00000619133.4 |
CD24 molecule |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 58.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 9.9 | 39.7 | GO:0032597 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 4.5 | 31.7 | GO:1901297 | arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 2.9 | 25.9 | GO:0007070 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 0.5 | 24.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.2 | 22.4 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 1.3 | 21.7 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.2 | 21.7 | GO:0030183 | B cell differentiation(GO:0030183) |
| 5.4 | 21.6 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.8 | 20.3 | GO:0051764 | actin crosslink formation(GO:0051764) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 58.6 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.7 | 39.7 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 3.8 | 34.3 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.9 | 32.7 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 23.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 2.5 | 22.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 22.0 | GO:0000785 | chromatin(GO:0000785) |
| 1.3 | 20.3 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.1 | 19.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.9 | 18.7 | GO:0070852 | cell body fiber(GO:0070852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 58.6 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 48.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.0 | 39.7 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 1.3 | 39.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 2.0 | 31.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 29.6 | GO:0001047 | core promoter binding(GO:0001047) |
| 1.4 | 25.9 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.4 | 24.9 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.5 | 24.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 24.1 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 72.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 39.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 36.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.6 | 35.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.6 | 31.8 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.9 | 25.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 1.2 | 23.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 18.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 17.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 14.1 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 58.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.7 | 38.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 34.8 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 1.9 | 34.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.7 | 21.2 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.3 | 20.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 1.7 | 20.3 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.3 | 19.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 19.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.9 | 18.9 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |