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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX11
Z-value: 0.49
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Transcription factors associated with SOX11
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX11 | hg38_v1_chr2_+_5692357_5692410 | 0.13 | 5.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX11
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_11892493 Show fit | 10.52 |
ENST00000422390.5
ENST00000618918.4 |
BTB domain containing 3 |
|
| chr15_+_80441229 Show fit | 10.04 |
ENST00000533983.5
ENST00000527771.5 ENST00000525103.1 |
aryl hydrocarbon receptor nuclear translocator 2 |
|
| chr5_+_72107453 Show fit | 7.97 |
ENST00000296755.12
ENST00000511641.2 |
microtubule associated protein 1B |
|
| chr4_-_89838289 Show fit | 7.14 |
ENST00000336904.7
|
synuclein alpha |
|
| chr13_-_44474296 Show fit | 6.68 |
ENST00000611198.4
|
TSC22 domain family member 1 |
|
| chr7_-_93890160 Show fit | 6.46 |
ENST00000451238.1
|
tissue factor pathway inhibitor 2 |
|
| chrX_-_13817027 Show fit | 6.42 |
ENST00000493677.5
ENST00000355135.6 ENST00000316715.9 |
glycoprotein M6B |
|
| chr9_-_14300231 Show fit | 5.55 |
ENST00000636735.1
|
nuclear factor I B |
|
| chr17_-_10114546 Show fit | 4.76 |
ENST00000323816.8
|
growth arrest specific 7 |
|
| chr8_-_13276491 Show fit | 4.18 |
ENST00000512044.6
|
DLC1 Rho GTPase activating protein |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.1 | 10.0 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.5 | 8.0 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 1.2 | 7.1 | GO:0051585 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 0.2 | 6.5 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
| 1.1 | 6.4 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 6.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 5.6 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.3 | 5.0 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.0 | 4.9 | GO:0007050 | cell cycle arrest(GO:0007050) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.2 | 10.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 8.7 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 8.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 7.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 6.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 6.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.3 | 5.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 4.0 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 4.0 | GO:0031527 | filopodium membrane(GO:0031527) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.5 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.7 | 10.0 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 8.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 8.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.2 | 7.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 4.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 4.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 3.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 3.7 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.2 | 3.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 7.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 5.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 4.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 3.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 2.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 2.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 5.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 2.6 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 2.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 2.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.9 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |