ISMARA results: SOX13

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX13_SOX12

Z-value: 1.24

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Transcription factors associated with SOX13_SOX12

Gene Symbol	Gene ID	Gene Info
SOX13 Ensembl NCBI GeneCards UniProt	ENSG00000143842.15	SOX13
SOX12 Ensembl NCBI GeneCards UniProt	ENSG00000177732.9	SOX12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX13	hg38_v1_chr1_+_204073104_204073121	0.17	1.3e-02	Click!
SOX12	hg38_v1_chr20_+_325536_325565	-0.06	3.8e-01	Click!

Activity profile of SOX13_SOX12 motif

Sorted Z-values of SOX13_SOX12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX13_SOX12

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr18_+_74534594 Show fit	23.57	ENST00000582365.1	CNDP1 Ensembl NCBI GeneCards UniProt Show fit	carnosine dipeptidase 1
chr19_+_21082140 Show fit	18.63	ENST00000616183.1 ENST00000596053.5	ZNF714 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 714
chr6_-_49744434 Show fit	18.56	ENST00000433368.6 ENST00000354620.4	CRISP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine rich secretory protein 3
chr10_+_68721012 Show fit	18.20	ENST00000536391.5 ENST00000630771.2	CCAR1 Ensembl NCBI GeneCards UniProt Show fit	cell division cycle and apoptosis regulator 1
chr18_+_74534493 Show fit	17.66	ENST00000358821.8	CNDP1 Ensembl NCBI GeneCards UniProt Show fit	carnosine dipeptidase 1
chr6_-_49744378 Show fit	16.25	ENST00000371159.8 ENST00000263045.9	CRISP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine rich secretory protein 3
chrX_+_108044967 Show fit	16.18	ENST00000415430.7	VSIG1 Ensembl NCBI GeneCards UniProt Show fit	V-set and immunoglobulin domain containing 1
chr12_+_8843236 Show fit	15.81	ENST00000541459.5	A2ML1 Ensembl NCBI GeneCards UniProt Show fit	alpha-2-macroglobulin like 1
chr19_-_32971909 Show fit	13.06	ENST00000305768.10 ENST00000590597.6 ENST00000591863.1	CEP89 Ensembl NCBI GeneCards UniProt Show fit	centrosomal protein 89
chrX_+_108045050 Show fit	12.68	ENST00000458383.1 ENST00000217957.10	VSIG1 Ensembl NCBI GeneCards UniProt Show fit	V-set and immunoglobulin domain containing 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	50.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.4	28.9	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.2	22.5	GO:0030449	regulation of complement activation(GO:0030449)
0.1	19.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3	19.3	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.6	16.7	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1	14.7	GO:0002377	immunoglobulin production(GO:0002377)
0.1	14.6	GO:0018210	peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.3	14.2	GO:0050832	defense response to fungus(GO:0050832)
0.2	12.0	GO:0016266	O-glycan processing(GO:0016266)

Showing 1 to 10 of 286 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	74.4	GO:0016021	integral component of membrane(GO:0016021)
0.0	62.9	GO:0005615	extracellular space(GO:0005615)
0.1	33.0	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.1	24.5	GO:0072562	blood microparticle(GO:0072562)
0.2	19.6	GO:0035580	specific granule lumen(GO:0035580)
0.9	17.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.3	13.8	GO:0048786	presynaptic active zone(GO:0048786)
1.1	13.1	GO:0097539	ciliary transition fiber(GO:0097539)
0.2	12.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	12.2	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 120 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	53.8	GO:0003823	antigen binding(GO:0003823)
0.0	52.7	GO:0003677	DNA binding(GO:0003677)
1.9	41.2	GO:0016805	dipeptidase activity(GO:0016805)
0.4	40.6	GO:0004984	olfactory receptor activity(GO:0004984)
0.4	34.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.3	20.5	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2	19.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	19.5	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2	14.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	14.7	GO:0005509	calcium ion binding(GO:0005509)

Showing 1 to 10 of 205 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	37.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	31.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	19.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	18.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	11.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.5	10.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	8.8	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.2	8.5	PID RAS PATHWAY	Regulation of Ras family activation
0.1	7.6	PID LKB1 PATHWAY	LKB1 signaling events
0.1	7.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	44.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	24.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	18.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	14.6	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
1.2	14.2	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.7	13.8	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	12.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5	11.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.7	11.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.7	10.9	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation

Showing 1 to 10 of 73 entries

Results for SOX13_SOX12

Z-value: 1.24

Motif logo

Transcription factors associated with SOX13_SOX12

Activity-expression correlation:

Activity profile of SOX13_SOX12 motif

Sorted Z-values of SOX13_SOX12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX13_SOX12

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: