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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX17
Z-value: 0.93
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Transcription factors associated with SOX17
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX17 | hg38_v1_chr8_+_54457927_54457943 | 0.12 | 7.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX17
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 51.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.3 | 24.8 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 1.2 | 13.0 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.1 | 11.8 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.4 | 10.2 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 3.1 | 9.4 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.2 | 9.2 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 1.8 | 9.0 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.1 | 9.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.4 | 8.7 | GO:0044458 | motile cilium assembly(GO:0044458) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.8 | GO:0005615 | extracellular space(GO:0005615) |
| 1.1 | 21.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 17.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 17.2 | GO:0031514 | motile cilium(GO:0031514) |
| 0.8 | 13.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 12.5 | GO:0005844 | polysome(GO:0005844) |
| 2.9 | 8.7 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.0 | 7.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 7.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.8 | 7.5 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 86.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 24.8 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.6 | 13.2 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.6 | 13.0 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.2 | 12.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.8 | 11.8 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.6 | 10.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 1.5 | 9.0 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 8.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.9 | 8.7 | GO:0032027 | myosin light chain binding(GO:0032027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 13.0 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 9.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 6.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.7 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 5.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.3 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 4.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 3.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 2.2 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 12.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.6 | 11.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 8.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.2 | 7.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 7.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 6.1 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 5.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 5.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.4 | 4.9 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |